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TRIM21 encodes a member of the tripartite motif (TRIM) family. Zusätzlich bieten wir Ihnen TRIM21 Proteine (17) und TRIM21 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 99 products:
Human Polyclonal TRIM21 Primary Antibody für ELISA, WB - ABIN249830
Chan, Di Donato, Hamel, Tseng, Buyon: 52-kD SS-A/Ro: genomic structure and identification of an alternatively spliced transcript encoding a novel leucine zipper-minus autoantigen expressed in fetal and adult heart. in The Journal of experimental medicine 1995
Human Polyclonal TRIM21 Primary Antibody für IF (p) - ABIN916527
Ahn, Hwang, Zheng, Bang, Kim: Enhancement of Th1/Th17 inflammation by TRIM21 in Behçet's disease. in Scientific reports 2017
We suggest that TRIM21 may be one of the factors associated with the "switching on" the proinflammatory programme in CD16 (zeige CD16 Antikörper)(+) monocytes or monocyte-derived macrophages.
Authors demonstrate that TRIM21 expression predicts survival in pancreatic cancer patients. This work highlights a novel mechanism of Par-4 (zeige PAWR Antikörper) regulation, and identifies a novel prognostic marker and potential therapeutic target for pancreatic cancer.
TRIM21 role in TRAIL-induced apoptosis
Our data suggest that patients with IIM, mainly DM, are characterized by a deficient expression of Ro52/TRIM21 in different PBMC subsets (CD4 (zeige CD4 Antikörper)(+) lymphocytes and monocytes), along with lower K48-mediated ubiquitination, which is associated with a proinflammatory cytokine response.
Significant relationships were found between clinical and laboratory manifestations of autoimmune and rheumatic diseases with different patterns of antibodies to anti-Ro52, anti-Ro60 (zeige TROVE2 Antikörper) and anti-La .
downregulation of miR (zeige MLXIP Antikörper)-1207-5p and miR (zeige MLXIP Antikörper)-4695-3p expression may lead to increased TRIM21 levels in the minor salivary glands, which contributes to the development of Sjogren's syndrome
The interaction of TRIM21 and LFG (zeige FAIM2 Antikörper) was analyzed by co-immunoprecipitation. To examine changes in regulatory processes, western blot analyses, real-time PCR, activity of apoptotic process and flow cytometric analyses were carried out.
TRIM21 plays an essential role in p62-regulated redox homeostasis and may be a viable target for treating pathological conditions resulting from oxidative damage.
TRIM21-induced exposure of the viral genome promotes sensing of DNA and RNA viruses by cGAS and RIG-I (zeige DDX58 Antikörper)
we prove that TRIM21 is a potential tumor suppressor in hepatocellular carcinoma and its low expression indicates poor prognosis
Antibody affinity modulates TRIM21 immune function. TRIM21 mediates neutralization under suboptimal conditions, whereas induction of immune signaling is balanced according to the functional affinity for the incoming immune stimuli.
Trim21, an estrogen receptor (zeige ESR1 Antikörper) coactivator, induces MYC (zeige MYC Antikörper) oncogene (zeige RAB1A Antikörper) by removing repressive CoAA (zeige RBM14 Antikörper) through E2-dependent degradation of CoAA (zeige RBM14 Antikörper).
results demonstrate that TRIM21 provides potent antiviral protection and forms an important part of the humoral immune response
Simultaneous neutralization and innate immune detection of replicating mouse adenovirus type 1 by TRIM21.
Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor (zeige FCGRT Antikörper) TRIM21.
TRIM21 is an interferon (zeige IFNA Antikörper)-inducible E3 ligase that induces the Lys48-linked ubiquitination and degradation of DDX41 (zeige DDX41 Antikörper) and negatively regulates the innate immune response to intracellular double-stranded DNA.
analysis of a novel role for tyrosine phosphorylation in regulating the interaction with IRF3 (zeige IRF3 Antikörper) and the activity of TRIM21 downstream of TLR3 (zeige TLR3 Antikörper) and TLR4 (zeige TLR4 Antikörper)
Ro52 is an E3 ligase for interferon (zeige IFNA Antikörper) regulatory factor (IRF)-8 (zeige IRF8 Antikörper) that acts in a non-degradation pathway of ubiquitination and contributes to the elicitation of innate immunity in macrophages.
TRIM21 is a previously undescribed type of IgG receptor based on a non-Ig scaffold whose interaction at the fundamental level-structural, thermodynamic, and kinetic-is evolutionarily conserved.
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.
tripartite motif-containing 21
, 52 kDa Ro protein-like
, tripartite motif containing 21
, 52 kDa Ro protein
, 52 kDa ribonucleoprotein autoantigen Ro/SS-A
, E3 ubiquitin-protein ligase TRIM21
, RING finger protein 81
, Sicca syndrome antigen A
, Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro)
, sjoegren syndrome type A antigen
, tripartite motif-containing protein 21
, 52kD Ro/SSA autoantigen
, Sjogren syndrome antigen A1
, tripartite motif protein 21