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TREH encodes an enzyme that hydrolyses trehalose, a disaccharide formed from two glucose molecules found mainly in fungi, plants, and insects. Zusätzlich bieten wir Ihnen TREH Kits (8) und TREH Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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both Tps1 and Treh mutant larvae exhibit a high lethality after desiccation stress. These results demonstrate that the regulation of trehalose metabolism is essential for normal development, body water homeostasis, and desiccation tolerance in Drosophila.
The present study holds significance in understanding the structural aspects of Drosophila trehalase in spite of unavailabilty of eukaryotic trehalase crystal structure.
Treh plays a role in neuroepithelial stem cell maintenance and differentiation during Drosophila optic lobe development.
these results indicate that trehalose has anti-apoptotic effects through the suppression of oxidative stress-induced mitochondrial injury and ER stress which is dependent on the promotion of autophagic flux and the induction of selective autophagy
In conclusion, we identified four novel loci (TGFA, PIK3R1, FGFR3 and TREH) and confirmed two loci known to be associated with cartilage thickness.The identified associations were not caused by rare exonic variants. This is the first report linking TGFA to human Osteoarthritis, which may serve as a new target for future therapies.
results suggest a significant association between the RETL1, TREH, and PHLDB1 genes and GBM development in the Han Chinese population
variants in TREH control trehalase activity, and although one of these variants is also reproducibly associated with T2D, it is likely that the effect of the SNP on risk of T2D occurs by a mechanism different than affecting trehalase activity.
we found three protective alleles for glioma patients, including the allele ''T'' of rs17748 in the TREH gene by recessive model (OR, 0.48; 95% CI, 0.23-1.01; P = 0.05) analysis
These results suggest that TREH acts as a stress-response protein in the kidney rather than involved in utilization of exogenous trehalose.
Trehalose was also able to restore cell viability to control levels, but pre-formed fibrils (PFFs)still exhibited toxic effects on the cells. These data provide essential information regarding effects of trehalose on alphaSyn accumulation and neuronal survival on exposure to PFF
in mature gut of conventional mice, both beta 1,4-galactosyltransferase and trehalase are elevated and insensitive to cartisone acetate
This gene encodes an enzyme that hydrolyses trehalose, a disaccharide formed from two glucose molecules found mainly in fungi, plants, and insects. A partial duplication of this gene is located adjacent to this locus on chromosome 11.
, alpha,alpha-trehalose glucohydrolase