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TRPV5 is a member of the transient receptor family and the TrpV subfamily.
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TRPV5 and TRPV6 lack a positively charged residue in the TM4 (zeige TPM4 ELISA Kits)-TM5 loop that was shown to interact with PI(4,5)P2 in TRPV1 (zeige TRPV1 ELISA Kits), which shows high affinity for this lipid
The alterations may lead to misfolding of TRPV5, reduction in translocation of the channel to the plasma membrane and/or impaired Ca(2 (zeige CA2 ELISA Kits)+) transport function of the channel, and ultimately disrupt TRPV5-mediated Ca(2 (zeige CA2 ELISA Kits)+) reabsorption.
These findings indicate that the A563T variation induces structural, dynamical, and electrostatic changes in the TRPV5 pore, providing structural insight into the functional alterations associated with the A563T variation.
Data found that a TRPV5 polymorphism (rs4236480) was observed to be associated with stone multiplicity of calcium nephrolithiasis, as the risk of stone multiplicity was higher in patients with the TT+CT genotype than in patients with the CC genotype
High TRPV5 expression is aassociated with adenoma of parathyroid glands.
Klotho (zeige KL ELISA Kits) up-regulates TRPV5 from both the inside and outside of cells.
Decreased expression of TRPV5 is associated with non-small cell lung cancer.
Upregulating the expression of TRPV5 can be utilized to manipulate transmembrane Ca2 (zeige CA2 ELISA Kits)+ transport, and may serve as an alternative for the treatment of Ca2 (zeige CA2 ELISA Kits)+ balance-related diseases.
These results suggest that TRPV5 and TRPV6 are crucial gates controlling cadmium and zinc levels in the human body.
these data showed that TRPV5/TRPV6 in human lymphocytes are functionally active, and their activity is associated with proliferative status of blood cells.
life-long challenge of Ca2 (zeige CA2 ELISA Kits)+ homeostasis present in Trpv5-/- mice causes accelerated bone aging and a low cortical and trabecular bone mass phenotype
beta-gal (zeige GLB1 ELISA Kits) is present in the pro-urine from where it is thought to stimulate TRPV5 activity.
A novel primary cell model with TRPV5-dependent Ca(2 (zeige CA2 ELISA Kits)+) transport characteristics was successfully established.
Phosphorylation of beta1-AR by PKA stimulates active Ca(2 (zeige CA2 ELISA Kits)+)influx through TRPV5.
The expression of TRPV5 channel is regulated by estrogen via estrogen receptor (zeige ESR1 ELISA Kits) in osteoblasts.
Uromodulin (zeige UMOD ELISA Kits) upregulates TRPV5 by decreasing caveolin-1 (zeige CAV1 ELISA Kits) dependent endocytosis of TRPV5.
In colitis in mice, tumor necrosis factor (zeige TNF ELISA Kits) and interferon-gamma (zeige IFNG ELISA Kits) reduced expression of Klotho (zeige KL ELISA Kits), which otherwise would protect TRPV5 from hypersialylation and cytokine-induced TRPV5 endocytosis, UBR4 (zeige UBR4 ELISA Kits)-dependent ubiquitination, degradation, and Ca(2 (zeige CA2 ELISA Kits)+) wasting.
The TRPV5 S682P mutant is a functionally significant factor in autosomal dominant hypercalciuria.
promoter driven Cre recombinase (zeige RAG1 ELISA Kits) expression will be useful for inducing DCT2 and CNT specific gene silencing of various channels, pumps, carriers, and receptors
Calcitonin (zeige CALCA ELISA Kits) augments the renal reabsorptive capacity for Ca(2 (zeige CA2 ELISA Kits)+). This increase is likely to occur independently of TRPV5.
mutation of a pore helix residue glutamate (zeige GRIN2A ELISA Kits)-535 to glutamine (zeige GFPT2 ELISA Kits) (E535Q) enhances the sensitivity of the channel to inhibition by extracellular protons
Results suggest that intracellular acidification directly inhibits TRPV5 by causing a conformational change(s) leading to a decrease of open probability of TRPV5 as well as of the single-channel conductance.
Activation of the CaR stimulates TRPV5-mediated Ca(2+) influx via a PMA-insensitive PKC isoform pathway.
TRPV5 and TRPV6 were upregulated with time and passage in culture suggesting that a shift in the phenotype of the cells in monolayer culture alters the expression of these channels.
In Equus caballus, TRPV5 mRNA is highly expressed in the kidney but scarce in the duodenum and heart. Protein expression followed a similar pattern.
This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level.
, calcium transporter 2
, epithelial calcium channel 1
, osm-9-like TRP channel 3
, transient receptor potential cation channel subfamily V member 5
, calcium transport protein 2
, transient receptor potential cation channel, subfamily V, member 5
, calcium transporter 2 L homeolog