Transient Receptor Potential Cation Channel, Subfamily M, Member 8 Proteine (TRPM8)

Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Zusätzlich bieten wir Ihnen TRPM8 Antikörper (171) und TRPM8 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TRPM8 79054 Q7Z2W7
TRPM8 171382 Q8R4D5
TRPM8 171384 Q8R455
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Showing 6 out of 10 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$582.75
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Escherichia coli (E. coli) Maus Unkonjugiert   5 applications Anmelden zum Anzeigen 1 bis 2 Tage
$318.85
Details

TRPM8 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine) ,
,
Rat (Rattus)

Weitere Proteine zu Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) Interaktionspartnern

Guinea Pig Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) Interaktionspartner

  1. The role of TRPM8 in the Guinea-pig bladder-cooling reflex investigated using a novel TRPM8 antagonist

Human Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) Interaktionspartner

  1. The present data suggest a possible theoretical foundation for the anti-inflammatory role of TRPM8 activation, providing an experimental basis that could contribute to the advancement of cooling therapy for trauma patients.

  2. Study shows that TRPM8 expression is significantly up-regulated in pancreatic cancer.

  3. Data show evidence of recent local ambient temperature adaptation on the cation channel (zeige TRPV1 Proteine) TRPM8.

  4. TRPM8 levels may be elevated in basal breast cancers, however, TRPM8 expression appears to be lost in many breast cancer cell lines

  5. In this study, we identify non-channel cytoplasmic small TRPM8 isoforms as putative regulator of PCa (zeige FLVCR1 Proteine) cell death

  6. Praziquantel is a relatively potent and selective partial agonist of the mammalian and avian cold and menthol receptor TRPM8.

  7. The TRPM8 transient receptor potential channel.

  8. our results indicate that enhanced TRPM8 hydrolysis in prostate cancer could present an adaptation mechanism, sustained via bypassing testosterone-induced rapid Ca2 (zeige CA2 Proteine)+ uptake through TRPM8, thus, diminishing the rates of apoptosis

  9. Suggest a novel, pore-independent molecular mechanism by which endogenous TRPM8 expression inhibits Rap1 (zeige RABGEF1 Proteine) GTPase (zeige RACGAP1 Proteine) and thus plays a critical role in the behavior of vascular endothelial cells by inhibiting migration.

  10. in this study, the glycosylation status of the TRPM8 channel was shown to affect cell proliferation, cell migration, and calcium uptake. TRPM8 expressed in the membrane of the Panc-1 pancreatic tumoral cell line is non-glycosylated, whereas human embryonic kidney cells transfected with human TRPM8 overexpress a glycosylated protein.

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) Interaktionspartner

  1. Data suggest that transient receptor potential melastatin (zeige TRPM1 Proteine) 8 (TRPM8) may represent a novel therapeutic target for combating obstructive airway diseases, such as asthma.

  2. These results suggest that TRPM8 expressed in tissues apart from cutaneous sensory nerves are involved in autonomic thermoregulation response.

  3. Since disruption of the clock machinery has been associated with many metabolic disorders, the pharmacological modulation of TRPM8 channel may become a promising therapeutic target to counterbalance weight gain, through increased thermogenesis, energy expenditure, and clock gene activation.

  4. These results suggest that TRPV4, TRPV3 and TRPM8 proteins, but not their ion channel activities are necessary for the induction of CIPs at 32 degrees C. Identification of proteins that differentially interact with these TRP channels at 37 degrees C and 32 degrees C would help elucidate the underlying mechanisms of CIP induction by hypothermia.

  5. Praziquantel is a relatively potent and selective partial agonist of the mammalian and avian cold and menthol receptor TRPM8.

  6. These results taken together with other reports suggest that TRPM8 containing sensory neurons are environmental cooling detectors that may be nociceptive or non-nociceptive depending on the sensitivity of individual fibers to different combinations of stimulus modalities.

  7. TRPM8 activation by dietary menthol improves energy metabolism and exercise endurance, which are likely driven by TRPM8-mediated Ca2 (zeige CA2 Proteine)+-dependent upregulation of PGC1alpha and its target genes involved in the mitochondrial function.

  8. TRPM8 in macrophages determines pro- or anti-inflammatory actions by regulating tumor necrosis factor-alpha (zeige TNF Proteine) and interleukin-10 (zeige IL10 Proteine) production. These findings suggest novel TRPM8-based options for immunomodulatory intervention.

  9. Here the authors show that AITC (allyl isothiocyanate; mustard oil) and menthol represent two distinct types of ligands at the mammalian cold sensor TRPM8.

  10. The results of this study show that chronic morphine upregulates TRPM8 channels, which is in contrast with the previous finding that acute morphine triggers TRPM8 internalization.

TRPM8 Protein Überblick

Protein Überblick

Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.

Genbezeichner und Symbole assoziert mit TRPM8

  • transient receptor potential cation channel subfamily M member 8 (TRPM8)
  • transient receptor potential cation channel subfamily M member 8b L homeolog (trpm8b.L)
  • transient receptor potential cation channel subfamily M member 8 (Trpm8)
  • transient receptor potential cation channel, subfamily M, member 8 (Trpm8)
  • transient receptor potential cation channel, subfamily M, member 8 (TRPM8)
  • CMR1 Protein
  • LTrpC-6 Protein
  • LTRPC6 Protein
  • Trp-p8 Protein
  • TRPM8 Protein
  • trpm8b Protein
  • TRPP8 Protein

Bezeichner auf Proteinebene für TRPM8

transient receptor potential cation channel, subfamily M, member 8 , transient receptor potential cation channel subfamily M member 8b , transient receptor potential cation channel subfamily M member 8 , transient potential cation channel subfamily M member 8 , LTrpC-6 , long transient receptor potential channel 6 , short form of the TRPM8 cationic channel , transient receptor potential p8 , transient receptor potential subfamily M member 8 , trp-p8 , TRP ion channel TRPM8 , transient receptor potential-p8 , cold menthol receptor 1 , cold/menthol receptor 1 , menthol receptor , transient receptor potential M8 protein , transient receptor potential cation channel, subfamily M, member 8 (predicted), 3 prime , transient receptor potential cation channel, subfamily M, member 8 (predicted), 5 prime

GENE ID SPEZIES
100137386 Papio anubis
100302012 Xenopus laevis
100337634 Cavia porcellus
79054 Homo sapiens
171382 Mus musculus
171384 Rattus norvegicus
424025 Gallus gallus
486170 Canis lupus familiaris
541151 Bos taurus
100328692 Oryctolagus cuniculus
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