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Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Zusätzlich bieten wir Ihnen TRPM8 Proteine (10) und TRPM8 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 170 products:
Fruit Fly (Drosophila melanogaster) Polyclonal TRPM8 Primary Antibody für ICC, IHC (fro) - ABIN152287
Peabody, Pohl, Diao, Vreede, Sandstrom, Wang, Zelensky, White: Characterization of the decision network for wing expansion in Drosophila using targeted expression of the TRPM8 channel. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
Show all 3 Pubmed References
Human Polyclonal TRPM8 Primary Antibody für ELISA - ABIN451742
Dhaka, Murray, Mathur, Earley, Petrus, Patapoutian: TRPM8 is required for cold sensation in mice. in Neuron 2007
Human Polyclonal TRPM8 Primary Antibody für ICC, IF - ABIN4362970
Wang, Yu, Yan, Lei, Chai, Jiang, Yuan, Xing, Du: TRPM8 in the negative regulation of TNFα expression during cold stress. in Scientific reports 2017
The role of TRPM8 in the Guinea-pig bladder-cooling reflex investigated using a novel TRPM8 antagonist
Data show evidence of recent local ambient temperature adaptation on the cation channel (zeige TRPV1 Antikörper) TRPM8.
TRPM8 levels may be elevated in basal breast cancers, however, TRPM8 expression appears to be lost in many breast cancer cell lines
In this study, we identify non-channel cytoplasmic small TRPM8 isoforms as putative regulator of PCa (zeige FLVCR1 Antikörper) cell death
Praziquantel is a relatively potent and selective partial agonist of the mammalian and avian cold and menthol receptor TRPM8.
The TRPM8 transient receptor potential channel.
our results indicate that enhanced TRPM8 hydrolysis in prostate cancer could present an adaptation mechanism, sustained via bypassing testosterone-induced rapid Ca2 (zeige CA2 Antikörper)+ uptake through TRPM8, thus, diminishing the rates of apoptosis
Suggest a novel, pore-independent molecular mechanism by which endogenous TRPM8 expression inhibits Rap1 (zeige RABGEF1 Antikörper) GTPase (zeige RACGAP1 Antikörper) and thus plays a critical role in the behavior of vascular endothelial cells by inhibiting migration.
in this study, the glycosylation status of the TRPM8 channel was shown to affect cell proliferation, cell migration, and calcium uptake. TRPM8 expressed in the membrane of the Panc-1 pancreatic tumoral cell line is non-glycosylated, whereas human embryonic kidney cells transfected with human TRPM8 overexpress a glycosylated protein.
This study demonstrates that TRPM8 (cold receptor) is present in nasal epithelium. When it is activated by moderate cooling at 24 degrees C or menthol, TRPM8 induces the secretion of mucin (zeige SLC13A2 Antikörper). This study determines that TRPM8 channels are important regulators of mucin (zeige SLC13A2 Antikörper) production. Therefore, TRPM8 antagonists could be used for the treatment of refractory rhinitis.
This study suggests that the TRPM8 sensor is a key determinant of germ cell fate under hypothermic stimulation.
These results suggest that TRPM8 expressed in tissues apart from cutaneous sensory nerves are involved in autonomic thermoregulation response.
Since disruption of the clock machinery has been associated with many metabolic disorders, the pharmacological modulation of TRPM8 channel may become a promising therapeutic target to counterbalance weight gain, through increased thermogenesis, energy expenditure, and clock gene activation.
These results suggest that TRPV4, TRPV3 and TRPM8 proteins, but not their ion channel activities are necessary for the induction of CIPs at 32 degrees C. Identification of proteins that differentially interact with these TRP channels at 37 degrees C and 32 degrees C would help elucidate the underlying mechanisms of CIP induction by hypothermia.
These results taken together with other reports suggest that TRPM8 containing sensory neurons are environmental cooling detectors that may be nociceptive or non-nociceptive depending on the sensitivity of individual fibers to different combinations of stimulus modalities.
TRPM8 activation by dietary menthol improves energy metabolism and exercise endurance, which are likely driven by TRPM8-mediated Ca2 (zeige CA2 Antikörper)+-dependent upregulation of PGC1alpha and its target genes involved in the mitochondrial function.
TRPM8 in macrophages determines pro- or anti-inflammatory actions by regulating tumor necrosis factor-alpha (zeige TNF Antikörper) and interleukin-10 (zeige IL10 Antikörper) production. These findings suggest novel TRPM8-based options for immunomodulatory intervention.
Here the authors show that AITC (allyl isothiocyanate; mustard oil) and menthol represent two distinct types of ligands at the mammalian cold sensor TRPM8.
The results of this study show that chronic morphine upregulates TRPM8 channels, which is in contrast with the previous finding that acute morphine triggers TRPM8 internalization.
data suggest that sex differences in the functioning of Ih and Ik in TRPM8 expressing primary afferent neurons leads to differences in cool temperature sensitivity
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
transient receptor potential cation channel, subfamily M, member 8
, transient receptor potential cation channel subfamily M member 8b
, transient receptor potential cation channel subfamily M member 8
, transient potential cation channel subfamily M member 8
, long transient receptor potential channel 6
, short form of the TRPM8 cationic channel
, transient receptor potential p8
, transient receptor potential subfamily M member 8
, TRP ion channel TRPM8
, transient receptor potential-p8
, cold menthol receptor 1
, cold/menthol receptor 1
, menthol receptor
, transient receptor potential M8 protein
, transient receptor potential cation channel, subfamily M, member 8 (predicted), 3 prime
, transient receptor potential cation channel, subfamily M, member 8 (predicted), 5 prime