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TRPM6 is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. Zusätzlich bieten wir Ihnen TRPM6 Kits (7) und TRPM6 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Results found that the haplotype containing two common TRPM6 SNPs (rs3750425 and rs2274924) increases the risk for proton pump inhibitor-induced hypomagnesemia.
TNF-alpha (zeige TNF Antikörper) rescues the EGFR (zeige EGFR Antikörper) tyrosine kinase (zeige TXK Antikörper) inhibitor-induced decrease in TRPM6 expression and Mg2 (zeige MUC7 Antikörper)+ influx mediated via the activation of an NF-kappaB (zeige NFKB1 Antikörper) signaling pathway.
A homozygous frame-shift mutation in the TRPM6 gene is associated with Hereditary hypomagnesemia with secondary hypocalcemia.
Data show that resistant cells express lower amounts of the transient receptor potential cation channel (zeige TRPV1 Antikörper) subfamily M TRPM6 and 7, both involved in magnesium transport.
The Different Roles of The Channel-Kinases TRPM6 and TRPM7 (zeige TRPM7 Antikörper)
we showed that two serum magnesium associated loci, MUC1 (zeige MUC1 Antikörper) and TRPM6, had significant effect modification with progestin use and insulin (zeige INS Antikörper) levels, respectively, in European Americans.
N-Myc (zeige MYCN Antikörper) can promote neuroblastoma (zeige ARHGEF16 Antikörper) cell proliferation through up-regulation of the channel kinases TRPM6 and TRPM7 (zeige TRPM7 Antikörper)
TRPM6 mRNA and protein levels in atrial fibrillation group were elevated markedly in comparison with sinus rhythm group.
Knowledge of TRPM6 functioning is of vital importance to decipher its role in Mg handling and will, in particular, provide a molecular basis for achieving a better understanding of Mg mal(re)absorption and hence systemic Mg balance.
Data indicate heteromer formation between channel kinases TRPM6 and TRPM7 (zeige TRPM7 Antikörper) influences the biological activity of the ion channels.
Hence, maintenance of organismal Mg(2 (zeige MCOLN1 Antikörper)+) balance by TRPM6 is crucial for prenatal development and survival to adulthood.
TRPM6 mRNA increased during the last 4 days of pregnancy, coinciding with fetal bone mineralization in mice. TRPM6 mRNA and protein was localized in the trophoblasts in labyrinth where the maternal-fetal Ca(2 (zeige CA2 Antikörper)+) transport occurs. In patch-clamp recordings, we observed TRPM6/TRPM7 (zeige TRPM7 Antikörper)-like currents in mouse trophoblasts after starting fetal bone mineralization but not before mineralization.
in a model of inherited hypomagnesemia, TRPM6 and TRPM7 (zeige TRPM7 Antikörper), but not paracellin-1 (zeige CLDN16 Antikörper), are downregulated
TRPM6 deletion is embryonic lethal in mice; Heterozygous deletion of TRPM6 results in a mild hypomagnesemia
consistently reduced expression of TRPM6 mRNA may play a role in the pathogenesis of hypomagnesemia in C57BL/6 asthmatic mice.
MsrB1 (zeige SEPX1 Antikörper) recovers TRPM6 channel activity by reducing the oxidation of Met(1755) and could, thereby, function as a modulator of TRPM6 during oxidative stress.
Trpm6(-/-) mice almost never survived to weaning and show neural tube defects.
In C57BL/6J mice, dietary Mg(2 (zeige MCOLN1 Antikörper)+)-restriction results in increased Mg(2 (zeige MCOLN1 Antikörper)+) (re)absorption, which is correlated with increased TRPM6 expression.
REA (zeige PHB2 Antikörper) operates as a negative feedback modulator of TRPM6 in the regulation of active Mg(2 (zeige MCOLN1 Antikörper)+) (re)absorption and provides new insight into the molecular mechanism of renal transepithelial Mg(2 (zeige MCOLN1 Antikörper)+) transport.
Modulation of TRPM6 and Na(+)/Mg(2 (zeige MCOLN1 Antikörper)+) exchange in mammary epithelial cells in response to variations of magnesium availability.
This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
transient receptor potential cation channel, subfamily M, member 6
, channel kinase 2
, melastatin-related TRP cation channel 6
, transient receptor potential cation channel subfamily M member 6
, transient receptor potential cation channel 6/channel-kinase 2