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TRPM5 encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. Zusätzlich bieten wir Ihnen TRPM5 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
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genetic association studies in populations in Northern Europe, Maghreb, and Sri (zeige SRI Antikörper) Lanka: Data suggest that SNPs in TAS2R50 (zeige TAS2R50 Antikörper) (rs1376251), TRPM5 (rs800345), and TAS2R16 (zeige TAS2R16 Antikörper) (rs860170) are associated with cultural food preferences; TAS2R16 (zeige TAS2R16 Antikörper) (rs860170) strongly differentiates populations and is associated to salicin bitterness perception. (TAS2R = taste receptor type 2)
Our results suggest roles of TRPM3 (zeige TRPM3 Antikörper) and TRPM5 gene variants in the susceptibility to or clinical expression of Systemic sclerosis
The PKC (zeige PRRT2 Antikörper)-dependent effect of GLP-1 (zeige GCG Antikörper) on membrane potential and electrical activity was mediated by activation of Na(+)-permeable TRPM4 (zeige TRPM4 Antikörper) and TRPM5 channels by mobilization of intracellular Ca(2 (zeige CA2 Antikörper)+) from thapsigargin-sensitive Ca(2 (zeige CA2 Antikörper)+) stores
In a Turkish population, genetic polymorphism in TRPM5 genes modify individual susceptibility to metabolic syndrome.
TRPM5-mediated Na(+) entry to promote Ca(2+) uptake via an NCX to trigger MUC5AC secretion
TrpM5 expression was similar throughout the olfactory glomeruli.
The TRPM5 gene rs34551253 (Ala456Thr) polymorphism may be associated with increased risk of developing primary open angle glaucoma in the Turkish population.
AZIN1 (zeige AZIN1 Antikörper) rs2679757 and TRPM5 rs886277 are associated with the risk of HBV-related liver cirrhosis in Chinese.
extracellular Zn(2+) inhibits TRPM5 channels, and the residues in the outer pore loop of TRPM5 are critically involved in the inhibition.
common TRPM5 variants are likely to be associated with prediabetic phenotypes; and this may in turn contribute to the development of type 2 diabetes mellitus
This physiological and behavioral results indicate that TRPM5-MCs (zeige SMCP Antikörper) play a protective role in maintaining the olfactory function of the mammalian main olfactory epithelium.
conclude that nAChR (zeige CHRNA4 Antikörper) subunits are expressed in Trpm5-positive TRCs and their expression levels are differentially altered by chronic oral exposure to nicotine and ethanol
propose that Skn-1a/Pou2f3 (zeige POU2F3 Antikörper) is the master regulator for the generation of the Trpm5-expressing microvillous cells in multiple tissues
This study demonstrate that Trpm5 is transiently expressed in a subpopulation of mature OSNs in the embryonic olfactory epithelium, indicating that Trpm5 channels could play a specific role in utero during a narrow developmental time window.
The PKC (zeige PKC Antikörper)-dependent effect of GLP-1 (zeige GCG Antikörper) on membrane potential and electrical activity was mediated by activation of Na(+)-permeable TRPM4 (zeige TRPM4 Antikörper) and TRPM5 channels by mobilization of intracellular Ca(2 (zeige CA2 Antikörper)+) from thapsigargin-sensitive Ca(2 (zeige CA2 Antikörper)+) stores
The present findings confirm and extend our recent findings that Trpm5 KO mice express significant preferences for 8% glucose and galactose.
Skn-1a (zeige POU2F3 Antikörper) is expressed in a minority of Mash1 (zeige ASCL1 Antikörper)-positive olfactory progenitor cells and a majority of Trpm5-expressing microvillous cells in the main olfactory epithelium.
The Trpm5 (but not T1r3 (zeige TAS1R3 Antikörper)) signaling is essential for starch preference, Trpm5 KO mice can learn to prefer starch based on its postoral effects.
This study show that olfactory sensory neurons expressing TRPM5 respond to pheromones, but not to regular odors through the opening of CNG (zeige CNGA1 Antikörper) channels leading to Ca2 (zeige CA2 Antikörper)+ gating of TRPM5
Evidence suggests that TRPM5 plays a role in mediating transduction for putative pheromones under conditions of reduced chemosensory input.
This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele.
transient receptor potential cation channel, subfamily M, member 5
, transient receptor potential cation channel subfamily M member 5-like
, MLSN1 and TRP-related
, MLSN1- and TRP-related gene 1 protein
, long transient receptor potential channel 5
, transient receptor potential cation channel subfamily M member 5
, long transient receptor potential-related channel 5