Transient Receptor Potential Cation Channel, Subfamily C, Member 3 Proteine (TRPC3)

The protein encoded by TRPC3 is a membrane protein that can form a non-selective channel permeable to calcium and other cations. Zusätzlich bieten wir Ihnen TRPC3 Antikörper (85) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TRPC3 7222 Q13507
TRPC3 22065  
Ratte TRPC3 TRPC3 60395  
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Showing 7 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
Escherichia coli (E. coli) Human Unkonjugiert   50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$310.00
Details

TRPC3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine) ,
,

Weitere Proteine zu Transient Receptor Potential Cation Channel, Subfamily C, Member 3 (TRPC3) Interaktionspartnern

Human Transient Receptor Potential Cation Channel, Subfamily C, Member 3 (TRPC3) Interaktionspartner

  1. Diacylglycerol generation downstream of VEGF receptors activatesTRPC3 causing Na(+) influx with subsequent reversal of NCX1, ERK1/2 activation and ultimately contributes to enhanced angiogenesis.

  2. TRPC3contributes to melanoma proliferation and migration through activation of STAT5 (zeige STAT5A Proteine)/Akt (zeige AKT1 Proteine) signaling.

  3. We also observed that acetylcholine attenuated the formation of NCX1 (zeige SLC8A1 Proteine)-TRPC3-IP3R1 (zeige ITPR1 Proteine) complexes and maintained calcium homeostasis in cells treated with TNF-alpha (zeige TNF Proteine).

  4. Data show clear inhibition of the photouncaging- induced Ca2+ signal by the TRPC3 channel inhibitor SKF 96365.

  5. The subsequent ER stress-induced apoptosis exhibit a strong requirement for constitutive Ca(2+) influx and that TRPC3 contributes to this process.

  6. Data show that mechanical stretching of transient receptor potential cation channel, subfamily C, member 3 (TRPC3) overexpressing fibroblasts induced the activation of nuclear factor-kappa B (NFkappaB).

  7. TRPC3 and TRPC6 (zeige TRPC6 Proteine) participate diversely in synaptic reorganization in the mossy fiber pathway in temporal lobe epilepsy.

  8. the first in vivo evidence for a proatherogenic role of endothelial TRPC3.

  9. Imin channels are regulated by STIM2 (zeige Stim2 Proteine), TRPC3-containing INS (zeige INS Proteine) channels are induced by STIM1 (zeige STIM1 Proteine), and TRPC1 (zeige TRPC1 Proteine)-composed Imax channels are activated by both STIM1 (zeige STIM1 Proteine) and STIM2 (zeige Stim2 Proteine).

  10. CaSR (zeige CASR Proteine) activation mediates Ca2 (zeige CA2 Proteine)+ influx and cell proliferation via TRPC3 and TRPC6 (zeige TRPC6 Proteine) in human mesangial cells

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily C, Member 3 (TRPC3) Interaktionspartner

  1. GPCR (zeige GPBAR1 Proteine)-arrestin (zeige SAG Proteine) complex initiates non-desensitized signalling at the plasma membrane by coupling with ion channels.

  2. These findings confirm an effect of TRPC3 on plaque necrosis and support the notion that this is likely a reflection of the reduced susceptibility of Trpc3-deficient M1 macrophages to apoptosis.

  3. Both TRPC3 blockade by GdCl3 or specific TRPC3 antibodies and gene silencing by siRNA inhibited the proliferation of airway smooth muscle cells. TRPC3 protein overexpression may be involved in airway smooth muscle hyperresponsiveness and remodeling in asthmatic mice.

  4. Sarcolemmal TRPC3, regulated by AT1R (zeige AGTRAP Proteine), causes the SSC (zeige CYP11A1 Proteine).

  5. The injury phase after myocardial infarcts occurs during reperfusion and is a consequence of calcium release from internal stores combined with calcium entry, leading to cell death. We identify canonical transient receptor potential channels (TRPC) 3/6/7 as the cation channels through which most of the damaging calcium enters cells to trigger their death, and we describe mechanisms activated during the injury phase.

  6. TRPC3 deletion prevents mechanical stress-induced ROS production and left ventricular dysfunction in pressure-overloaded heart. TRPC3 specifically contributed to the upregulation of Nox2 in pressure-overloaded heart. TRPC3 participates in pressure overload-induced LV dysfunction in 129 Sv mice.

  7. TRPC3-induced Ca2+ entry promotes astrocyte proliferation and migration i.e. astrocyte activity in vitro which is attenuated by the presence of TRPC1. Following brain injury, the absence of TRPC3 results in a significant reduction of astrogliosis and cortical edema in vivo, suggesting that a targeted therapy to reduce TRPC3 channel activity might be beneficial in traumatic brain injury.

  8. Study shows that the age-dependent alpha-syn accumulation is correlated with an elevation of TRPC3 in the mitochondrial fractions isolated from monkey and mouse brains. In animal and cell models, alpha-syn overexpression was accompanied by an elevation of alpha-syn and TRPC3 in the mitochondrial fractions, and alpha-syn downregulation was associated with a reduction of the mitochondrial alpha-syn and TRPC3.

  9. Downregulation of TRPC3 in liver sinusoid endothelial cells reduces their susceptibility to endoplasmic reticulum stress-induced apoptosis.

  10. In the present study, we have explored the hypothesis that TRPC3 and TRPC6 (zeige TRPC6 Proteine) channels expressed in VSMCs may have a differential contribution to the regulation of vascular tone, which could be relevant for the changes in vascular reactivity associated with essential hypertension

Pig (Porcine) Transient Receptor Potential Cation Channel, Subfamily C, Member 3 (TRPC3) Interaktionspartner

  1. Data suggest that activation of adenosine A1 receptors elicit receptor-operated Ca(2+) entry in porcine afferent arterioles, the level of which is dependent on postnatal maturation of TRPC3 channels.

  2. Demonstrate that Ca(2+) entry via endothelial TRPC3 contributes to nitric oxide release and have revealed that hypoxia-reoxygenation is associated with inhibition of TRPC3 activity.

  3. Study determined the sequence of pig TRPC1 and TRPC3-7 channels and found pig TRPC cDNAs resemble their human homologs more than the others .

  4. heteromeric cation channels comprised of the TRPP2 mutant and the TRPC3 or TRPC7 (zeige TRPM2 Proteine) protein induce enhanced receptor-activated Ca(2 (zeige CA2 Proteine)+) influx that may lead to dysregulated cell growth in ADPKD

TRPC3 Protein Überblick

Protein Überblick

The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit TRPC3

  • transient receptor potential cation channel subfamily C member 3 (TRPC3)
  • transient receptor potential cation channel, subfamily C, member 3 (TRPC3)
  • transient receptor potential cation channel subfamily C member 3 (Trpc3)
  • transient receptor potential cation channel, subfamily C, member 3 (Trpc3)
  • Mwk Protein
  • Trcp3 Protein
  • Trp3 Protein
  • Trpc3 Protein
  • TrpC3c Protein
  • Trrp3 Protein

Bezeichner auf Proteinebene für TRPC3

transient receptor potential cation channel, subfamily C, member 3 , short transient receptor potential channel 3-like , short transient receptor potential channel 3 , hTrp-3 , transient receptor protein 3 , TRP-3 , mTrp3 , receptor-activated cation channel TRP3 , trp-related protein 3 , ion channel protein , transient receptor potential cation channel subfamily C member 3 , oocyte transient receptor potential channel

GENE ID SPEZIES
100072204 Equus caballus
428766 Gallus gallus
471294 Pan troglodytes
100135636 Cavia porcellus
100454158 Pongo abelii
100483524 Ailuropoda melanoleuca
7222 Homo sapiens
22065 Mus musculus
60395 Rattus norvegicus
483844 Canis lupus familiaris
397210 Sus scrofa
286866 Bos taurus
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