Transient Receptor Potential Cation Channel, Subfamily C, Member 1 Proteine (TRPC1)

TRPC1 encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Zusätzlich bieten wir Ihnen Transient Receptor Potential Cation Channel, Subfamily C, Member 1 Antikörper (89) und Transient Receptor Potential Cation Channel, Subfamily C, Member 1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TRPC1 7220 P48995
Ratte TRPC1 TRPC1 89821 Q9QX01
TRPC1 22063 Q61056
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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TRPC1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
, ,
Mouse (Murine)
,

Weitere Proteine zu Transient Receptor Potential Cation Channel, Subfamily C, Member 1 (TRPC1) Interaktionspartnern

Human Transient Receptor Potential Cation Channel, Subfamily C, Member 1 (TRPC1) Interaktionspartner

  1. TRPC1/Orai1 may form a complex that mediates Ca(2+) influx and nitric oxide production via activating store-operated calcium channel and receptor-operated calcium channel activation.

  2. these results suggest that dopaminergic neurotoxins initially decreased Ca(2+) entry, which inhibited the binding of NF-kappaB to the TRPC1 promoter, thereby inhibiting TRPC1 expression and resulting in cell death by preventing autophagy.

  3. TRPC1 regulated HIF1alpha levels in PTEN-deficient MDA-MB-468 and HCC1569 breast cancer cell lines. This regulation arises from effects on the constitutive translation of HIF1alpha under normoxic conditions via an Akt-dependent pathway.

  4. Store-operated calcium entry (SOCE), a unique plasma membrane Ca(2+) entry mechanism, is activated when ER-[Ca(2+)] is decreased. SOCE is mediated via the primary channel, Orai1, as well as others such as TRPC1.

  5. the role of TRPC1 in the development of podocyte injury and disorders of the podocyte cytoskeleton, which may contribute to the development of novel therapeutics for podocyte injury-associated kidney diseases.

  6. TRPC1 is a primary candidate in forming SOCC that stimulates CaSRinduced SOCE and NO production in HUVECs

  7. TRPC1-STIM1 activation modulates transforming growth factor beta-induced epithelial-to-mesenchymal transition and cell migration.

  8. role in the odontoblast-like differentiation of dental pulp cells

  9. Data show that RNAi-mediated knockdown of KCa3.1 and/or TRPC1 leads to a significant decrease in cell proliferation due to cell cycle arrest in the G1 phase

  10. Data indicate that the inhibition of the Store Operated Calcium Entry (SOCE)-dependent colon cancer cell migration through SK3/TRPC1/Orai1 channel complex by the alkyl-lipid Ohmline may be a strategy to modulate Anti-EGFR mAb action in metastatic colorectal cancer (mCRC).

  11. This study provided direct evidence that increasing extracellular Ca(2+) enhanced TNF-alpha-induced VCAM-1 activation and monocytes adhesion. Moreover, we identified a novel TRPC1/ERK1/2/NFkappaB signaling pathway mediating VCAM-1 activation and monocyte adhesion in this pathological process.

  12. These observations suggest that mechanical stretch may induce an influx of Ca(2+) and up-regulation of IL-13 and MMP-9 expression in 16HBE cells via activation of TRPC1

  13. STIM1L and TRPC1/4 are working together in myotubes to ensure efficient store refilling and a proper differentiation program.

  14. SARAF modulates TRPC1, but not TRPC6, channel function in a STIM1-independent manner

  15. These findings suggest identification of an important experimental tool compound, which has much higher potency for inhibiting TRPC1/4/5 channels than previously reported agents, impressive specificity, and graded subtype selectivity within the TRPC1/4/5 channel family.

  16. changes in cell cycle regulating genes in TRPC1-silenced cells indicate possible cell cycle arrest along with compensatory up-regulation of ERBB3 growth factor receptor-amongst others-to maintain hepatocellular carcinoma cell proliferation.

  17. OC. Our results provide the basis for further investigations of the drug-resistance-related functions of TRPC1 in ovarian cancer and other forms of cancer.

  18. TRPC1 mRNA and protein levels were increased in FCDIa, FCDIIa, and FCDIIb patients.

  19. HIF-1alpha knockdown attenuated hypoxia-induced BMP4 expression and knockdown of either HIF-1alpha or BMP4 abolished hypoxia-induced TRPC expression and basal [Ca(2+)]i.

  20. In c-kit+ cardiac progenitor cells, silencing TRPC1 significantly reduced the Ca2+ signaling through store-operated Ca2+ channels, decreased cell proliferation and migration, and reduced expression of cyclin D1, cyclin E, and/or p-Akt.

Xenopus laevis Transient Receptor Potential Cation Channel, Subfamily C, Member 1 (TRPC1) Interaktionspartner

  1. Endogenous as well as overexpressed xTRPV6 interacts with xTRPC1.

  2. our results suggest that calcium influx through mechanosensitive TRPC1 channels on filopodia activates calpain to control growth cone turning during development.

  3. This study suggested that BDNF-induced synaptic potentiation involves coordinated presynaptic and postsynaptic responses and identifies TRPC1 as a molecular mediator for postsynaptic Ca2+ elevation required for BDNF-induced synaptic plasticity.

  4. XTRPC1, a Xenopus homolog of mammalian TRPC1, is required for proper growth cone turning responses of Xenopus spinal neurons to netrin-1, brain-derived neurotrophic factor and myelin-associated glycoprotein, but not to semaphorin 3A.

  5. downregulation of Xenopus TRP-1 (xTRPC1) expression with a specific morpholino oligonucleotide abolished the growth-cone turning and Ca2+ elevation induced by a netrin-1 gradient

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily C, Member 1 (TRPC1) Interaktionspartner

  1. TRPC1 deficiency potentiates Reactive Oxygen Species generation via Nox4-containing NADPH oxidase, which exacerbates cerebral Ischemia/Reperfusion injury.

  2. these results suggest that dopaminergic neurotoxins initially decreased Ca(2+) entry, which inhibited the binding of NF-kappaB to the TRPC1 promoter, thereby inhibiting TRPC1 expression and resulting in cell death by preventing autophagy.

  3. the role of TRPC1 in the development of podocyte injury and disorders of the podocyte cytoskeleton, which may contribute to the development of novel therapeutics for podocyte injury-associated kidney diseases.

  4. By use of electrophysiology and intracellular Ca2+ imaging, this study characterises a Ca2+ permeable channel in white adipocytes. The current shows functional characteristics resembling the Ca2+ -permeable transient receptor potential channel 1 (TRPC1).

  5. Silencing of beta 1 integrin gene regulates the gene expression of storeoperated Ca2+ entry (SOCE)-associated genes (STIM1, ORAI1 and TRPC1).

  6. TRPC3-induced Ca2+ entry promotes astrocyte proliferation and migration i.e. astrocyte activity in vitro which is attenuated by the presence of TRPC1. Following brain injury, the absence of TRPC3 results in a significant reduction of astrogliosis and cortical edema in vivo, suggesting that a targeted therapy to reduce TRPC3 channel activity might be beneficial in traumatic brain injury.

  7. Data show that transient receptor potential channel 1 (TRPC1) deficiency caused neuronal apoptosis in basal ganglia.

  8. TRPC1 is indispensable for the enriched environment-induced hippocampal neurogenesis and cognitive enhancement.

  9. Data (including data from studies using knockout mice) suggest that TRPC1 inhibits positive effects of exercise on insulin resistance and type II diabetes in a high-fat diet-induced obesity environment.

  10. TRPC1 regulated directly or indirectly the expression of multiple proteins, which may be crucial for the maintenance of memory ability.

  11. we confirmed that the activation of OTX2, a determinant of DA neuron development and the expression of which is induced by thyroid hormone, is dependent on TRPC1-mediated calcium signaling.

  12. These results indicate the contribution of heteromultimeric channels from TRPC1, TRPC4, and TRPC5 subunits to the regulation of mechanisms underlying spatial working memory and flexible relearning by facilitating proper synaptic transmission in hippocampal neurons.

  13. Ca(2+) entry serves critical cellular functions in virtually every cell type, and appropriate regulation of Ca(2+) in neurons is essential for proper function.

  14. Down-regulation of TRPC1 in weight-bearing soleus muscles resulted in reduced muscle mass and reduced myofibre cross-sectional area.

  15. these data indicate for the first time a functional interaction between Orai1, TRPC1, and CaV1.2 channels in Vascular Smooth Muscle Cells, confirming that upon agonist stimulation, vessel contraction involves Ca(2+) entry due to co-activation of Orai1- and TRPC1-dependent store-operated Ca(2+) channels and L-type Ca(2+) channels.

  16. mechanosensitive TRPC1 channels in murine PSCs exposed to elevated ambient pressure

  17. The results of this study showed that Loss of TRPC1 facilitated the gliotic response induced by increased intraocular pressure (IOP), suggesting that the channel might contribute to the glial mechanosusceptibility.

  18. transient receptor potential channel 1 suppression of basal sphingosine kinase 1 activity enables endothelial cell-barrier destabilization by edemagenic agonists

  19. Together the data suggests that Ca(2+) entry via the TRPC1 channels is essential for the activation of CaCC

  20. TRPC1(-/-) mice exhibited decreased survival, severe lung injury, and systemic bacterial dissemination upon infection.

Cow (Bovine) Transient Receptor Potential Cation Channel, Subfamily C, Member 1 (TRPC1) Interaktionspartner

  1. TRPC channel subunits 1 and 4 interact in bovine endothelial cells

  2. the link between HG-induced changes in TRPC1 expression, enhanced Ca(2+) entry, and endothelial dysfunction require further study

Zebrafish Transient Receptor Potential Cation Channel, Subfamily C, Member 1 (TRPC1) Interaktionspartner

  1. These results provide the first in vivo evidence that TRPC1 is essential for angiogenesis in zebrafish.

Pig (Porcine) Transient Receptor Potential Cation Channel, Subfamily C, Member 1 (TRPC1) Interaktionspartner

  1. Demonstrate a novel role of the NO-cGMP-PKG pathway in the inhibition of 11,12-EET-induced smooth muscle hyperpolarization and relaxation via PKG-mediated phosphorylation of TRPC1.

  2. Data found that the pig adrenal medulla expressed predominantly TRPC1, TRPC5, and TRPC6 transcripts. The expression level of these TRPCs was significantly elevated in the adrenal medulla from pigs with metabolic syndrome.

Rabbit Transient Receptor Potential Cation Channel, Subfamily C, Member 1 (TRPC1) Interaktionspartner

  1. Heteromeric TRPV4-TRPC1 channels mediate CaSR-induced vasorelaxation through NO production but not IKCa channel activation in rabbit mesenteric arteries.

  2. a novel activation mechanism for TRPC1 SOCs in VSMCs, in which store depletion induces formation of TRPC1-Galphaq-PLCbeta1 complexes that lead to PKC stimulation and channel gating.

Transient Receptor Potential Cation Channel, Subfamily C, Member 1 (TRPC1) Protein Überblick

Protein Überblick

The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit TRPC1

  • transient receptor potential cation channel subfamily C member 1 (TRPC1)
  • transient receptor potential cation channel, subfamily C, member 1 (Trpc1)
  • transient receptor potential cation channel, subfamily C, member 1 L homeolog (trpc1.L)
  • transient receptor potential cation channel, subfamily C, member 1 (trpc1)
  • transient receptor potential cation channel subfamily C member 1 (trpc1)
  • HTRP-1 Protein
  • Mtrp1 Protein
  • Trp1 Protein
  • Trpc1 Protein
  • Trrp1 Protein
  • xtrpc1 Protein

Bezeichner auf Proteinebene für TRPC1

TRP-1 , short transient receptor potential channel 1 , transient receptor potential canonical 1 , transient receptor protein 1 , transient receptor potential protein , trp-related protein 1 , transient receptor potential channel 1 , store-operated calcium channel , transient receptor potential channel subfamily C member 1 , transient receptor potential cation channel, subfamily C, member 1 , transient receptor potential cation channel subfamily C member 1 , short transient receptor potential channel 1-like , calcium influx channel TRPC1A , putative calcium influx channel TRPC1A

GENE ID SPEZIES
7220 Homo sapiens
89821 Rattus norvegicus
399136 Xenopus laevis
22063 Mus musculus
282100 Bos taurus
424776 Gallus gallus
570841 Danio rerio
100156938 Sus scrofa
100219592 Taeniopygia guttata
100462673 Oncorhynchus mykiss
100465650 Ailuropoda melanoleuca
100556438 Anolis carolinensis
100009352 Oryctolagus cuniculus
485698 Canis lupus familiaris
100062355 Equus caballus
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