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TRPC1 encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway.
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the role of TRPC1 in the development of podocyte injury and disorders of the podocyte cytoskeleton, which may contribute to the development of novel therapeutics for podocyte injury-associated kidney diseases.
TRPC1 is a primary candidate in forming SOCC that stimulates CaSRinduced SOCE and NO production in HUVECs
TRPC1-STIM1 activation modulates transforming growth factor beta-induced epithelial-to-mesenchymal transition and cell migration.
Data show that RNAi-mediated knockdown of KCa3.1 and/or TRPC1 leads to a significant decrease in cell proliferation due to cell cycle arrest in the G1 phase
Data indicate that the inhibition of the Store Operated Calcium Entry (SOCE)-dependent colon cancer cell migration through SK3/TRPC1/Orai1 (zeige ORAI1 ELISA Kits) channel complex by the alkyl-lipid Ohmline may be a strategy to modulate Anti-EGFR (zeige EGFR ELISA Kits) mAb action in metastatic colorectal cancer (mCRC).
This study provided direct evidence that increasing extracellular Ca(2 (zeige CA2 ELISA Kits)+) enhanced TNF-alpha (zeige TNF ELISA Kits)-induced VCAM-1 (zeige VCAM1 ELISA Kits) activation and monocytes adhesion. Moreover, we identified a novel TRPC1/ERK1/2 (zeige MAPK1/3 ELISA Kits)/NFkappaB (zeige NFKB1 ELISA Kits) signaling pathway mediating VCAM-1 (zeige VCAM1 ELISA Kits) activation and monocyte adhesion in this pathological process.
These observations suggest that mechanical stretch may induce an influx of Ca(2 (zeige CA2 ELISA Kits)+) and up-regulation of IL-13 (zeige IL13 ELISA Kits) and MMP-9 (zeige MMP9 ELISA Kits) expression in 16HBE cells via activation of TRPC1
STIM1L (zeige STIM1 ELISA Kits) and TRPC1/4 are working together in myotubes to ensure efficient store refilling and a proper differentiation program.
SARAF modulates TRPC1, but not TRPC6 (zeige TRPC6 ELISA Kits), channel function in a STIM1 (zeige STIM1 ELISA Kits)-independent manner
These findings suggest identification of an important experimental tool compound, which has much higher potency for inhibiting TRPC1/4/5 channels than previously reported agents, impressive specificity, and graded subtype selectivity within the TRPC1/4/5 channel family.
Endogenous as well as overexpressed xTRPV6 interacts with xTRPC1.
our results suggest that calcium influx through mechanosensitive TRPC1 channels on filopodia activates calpain to control growth cone turning during development.
This study suggested that BDNF (zeige BDNF ELISA Kits)-induced synaptic potentiation involves coordinated presynaptic and postsynaptic responses and identifies TRPC1 as a molecular mediator for postsynaptic Ca2 (zeige CA2 ELISA Kits)+ elevation required for BDNF (zeige BDNF ELISA Kits)-induced synaptic plasticity.
XTRPC1, a Xenopus homolog of mammalian TRPC1, is required for proper growth cone turning responses of Xenopus spinal neurons to netrin-1 (zeige NTN1 ELISA Kits), brain-derived neurotrophic factor (zeige BDNF ELISA Kits) and myelin-associated glycoprotein (zeige MAG ELISA Kits), but not to semaphorin 3A (zeige SEMA3A ELISA Kits).
downregulation of Xenopus TRP-1 (zeige TYRP1 ELISA Kits) (xTRPC1) expression with a specific morpholino oligonucleotide abolished the growth-cone turning and Ca2 (zeige CA2 ELISA Kits)+ elevation induced by a netrin-1 (zeige NTN1 ELISA Kits) gradient
By use of electrophysiology and intracellular Ca2 (zeige CA2 ELISA Kits)+ imaging, this study characterises a Ca2 (zeige CA2 ELISA Kits)+ permeable channel in white adipocytes. The current shows functional characteristics resembling the Ca2 (zeige CA2 ELISA Kits)+ -permeable transient receptor potential channel 1 (TRPC1).
Silencing of beta 1 integrin gene regulates the gene expression of storeoperated Ca2 (zeige CA2 ELISA Kits)+ entry (SOCE)-associated genes (STIM1 (zeige STIM1 ELISA Kits), ORAI1 and TRPC1).
TRPC3-induced Ca2+ entry promotes astrocyte proliferation and migration i.e. astrocyte activity in vitro which is attenuated by the presence of TRPC1. Following brain injury, the absence of TRPC3 results in a significant reduction of astrogliosis and cortical edema in vivo, suggesting that a targeted therapy to reduce TRPC3 channel activity might be beneficial in traumatic brain injury.
Data show that transient receptor potential channel 1 (TRPC1) deficiency caused neuronal apoptosis in basal ganglia.
TRPC1 is indispensable for the enriched environment-induced hippocampal neurogenesis and cognitive enhancement.
Data (including data from studies using knockout mice) suggest that TRPC1 inhibits positive effects of exercise on insulin (zeige INS ELISA Kits) resistance and type II diabetes in a high-fat diet-induced obesity environment.
TRPC1 regulated directly or indirectly the expression of multiple proteins, which may be crucial for the maintenance of memory ability.
we confirmed that the activation of OTX2 (zeige OTX2 ELISA Kits), a determinant of DA neuron development and the expression of which is induced by thyroid hormone (zeige PTH ELISA Kits), is dependent on TRPC1-mediated calcium signaling.
These results indicate the contribution of heteromultimeric channels from TRPC1, TRPC4, and TRPC5 subunits to the regulation of mechanisms underlying spatial working memory and flexible relearning by facilitating proper synaptic transmission in hippocampal neurons.
the link between HG-induced changes in TRPC1 expression, enhanced Ca(2 (zeige CA2 ELISA Kits)+) entry, and endothelial dysfunction require further study
These results provide the first in vivo evidence that TRPC1 is essential for angiogenesis in zebrafish.
Demonstrate a novel role of the NO-cGMP-PKG (zeige PRKG1 ELISA Kits) pathway in the inhibition of 11,12-EET-induced smooth muscle hyperpolarization and relaxation via PKG (zeige PRKG1 ELISA Kits)-mediated phosphorylation of TRPC1.
Data found that the pig adrenal medulla expressed predominantly TRPC1, TRPC5, and TRPC6 (zeige TRPC6 ELISA Kits) transcripts. The expression level of these TRPCs was significantly elevated in the adrenal medulla from pigs with metabolic syndrome.
Heteromeric TRPV4 (zeige TRPV4 ELISA Kits)-TRPC1 channels mediate CaSR (zeige CASR ELISA Kits)-induced vasorelaxation through NO production but not IKCa channel activation in rabbit mesenteric arteries.
a novel activation mechanism for TRPC1 SOCs in VSMCs, in which store depletion induces formation of TRPC1-Galphaq-PLCbeta1 complexes that lead to PKC stimulation and channel gating.
The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene.
, short transient receptor potential channel 1
, transient receptor potential canonical 1
, transient receptor protein 1
, transient receptor potential protein
, trp-related protein 1
, transient receptor potential channel 1
, store-operated calcium channel
, transient receptor potential channel subfamily C member 1
, transient receptor potential cation channel, subfamily C, member 1
, transient receptor potential cation channel subfamily C member 1
, short transient receptor potential channel 1-like
, calcium influx channel TRPC1A
, putative calcium influx channel TRPC1A