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TFCP2 encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. Zusätzlich bieten wir Ihnen Transcription Factor CP2 Proteine (8) und Transcription Factor CP2 Kits (7) und viele weitere Produktgruppen zu diesem Protein an.
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Dog (Canine) Monoclonal TFCP2 Primary Antibody für IF, WB - ABIN968193
Shirra, Zhu, Huang, Pallas, Hansen: One exon of the human LSF gene includes conserved regions involved in novel DNA-binding and dimerization motifs. in Molecular and cellular biology 1994
Show all 2 Pubmed References
The results suggest potential roles of LSF (TFCP2 ) as a growth regulator through control of the transcription of p21CIP1 (zeige CDKN1A Antikörper) in melanocytes and melanoma cells as well as a biomarker for nevus.
Complement proteins C7 and CFH (zeige CFH Antikörper) control the stemness of liver cancer cells via LSF-1 pathway.
LSF is an important mediator in colorectal carcinoma tumorigenesis and progression, and LSF expression is an important index for and prognostic prediction.
Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene (zeige RAB1A Antikörper) addiction to LSF in hepatocellular carcinoma
Secreted OPN (zeige SPP1 Antikörper), induced by LSF, activates c-Met via a potential interaction between OPN (zeige SPP1 Antikörper) and its cell surface receptor CD44 (zeige CD44 Antikörper). A significant correlation was observed among LSF, OPN (zeige SPP1 Antikörper), and activated c-Met levels in HCC (zeige FAM126A Antikörper).
Inhibition of MMP-9 (zeige MMP9 Antikörper) significantly abrogated LSF-induced angiogenesis as well as in vivo tumorigenesis, thus reinforcing the role of MMP-9 (zeige MMP9 Antikörper) in facilitating LSF function.
Data suggest that LSF is a key mediator of the Notch1 (zeige NOTCH1 Antikörper) signaling pathway, suggesting that it might be a novel therapeutic target for the treatment of hepatocellular carcinoma.
Study show that CRTR-1 (zeige TFCP2L1 Antikörper) is generally an activator of transcription (zeige STAT1 Antikörper) and that it modulates the activity of other family members, CP2 (zeige CP Antikörper), NF2d9 (zeige UBP1 Antikörper) and altNF2d9, in a cell specific manner.
SRY (zeige SRY Antikörper) is a hybrid of DGCR8 (zeige DGCR8 Antikörper) and SOX3 (zeige SOX3 Antikörper), and is regulated by the transcription factor CP2.
The expression of osteopontin (OPN (zeige SPP1 Antikörper)), a gene regulating every step in tumor progression and metastasis, was robustly up-regulated by LSF.
The transcription factor CP2 upregulated miR (zeige MLXIP Antikörper)-144 expression, which partially contributed to the suppression of COX-2 (zeige COX2 Antikörper) in mGCs.
that yin yang 1 (zeige YY1 Antikörper) strongly localizes in the spermatogonial stem cells and co-localizes heterogeneously with CP2c to permit spermatogenesis
present study shows that a transcription factor previously unrelated with epithelial-mesenchymal transition (EMT (zeige ITK Antikörper)), TFCP2c/LSF/LBP-1c, was translocated to the nucleus and bound to the fibronectin (zeige FN1 Antikörper) promoter upon EMT (zeige ITK Antikörper) induction by Snail1 (zeige SNAI1 Antikörper)
the binding of Pin1 (zeige PIN1 Antikörper) at the Thr (zeige TRH Antikörper)-329-Pro-330 motif in LSF permits isomerization by Pin1 (zeige PIN1 Antikörper) of the peptide bonds at the nearby phosphorylated SP motifs (Ser (zeige SIGLEC1 Antikörper)-291 and Ser (zeige SIGLEC1 Antikörper)-309) to the trans configuration, thereby facilitating their dephosphorylation.
CP2 contributes to the pathogenesis of Alzheimer's disease by inducing transferrin (zeige Tf Antikörper) expression via up-regulating its transcription.
CP2 is a major factor in the regulation of globin expression in human and mouse erythroid cells, and CP2 binding to the globin gene promoter is essential for the enhanced transcription of globin genes in erythroid differentiation.
CP2 plays important role during bone development by activating BMP4 (zeige BMP4 Antikörper) transcription
A novel murine splice isoform of CP2, CP2b (zeige CYP27B1 Antikörper), which is identical to CP2a except that it has an additional 36 amino acids encoded by an extra exon was identified and characterized.
findings demonstrate that the APLP2-intracellular C-terminal domains interact with CP2 transcription factor in the nucleus and induce the expression of glycogen synthase kinase 3beta
This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease.
transcription factor CP2
, cCP2 transcription factor
, SAA3 enhancer factor
, alpha-globin transcription factor CP2