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The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly..
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Tlk2 promotes Asf1A (zeige ASF1A Antikörper) function during the DNA damage response in G2 to allow for proper restoration of chromatin structure at the break site and subsequent recovery from the arrest.
Results show that TLK2 overexpression correlates with increased genome-wide copy number aberrations in breast cancer cells, impairs cell-cycle checkpoint signaling in response to DNA damage.
TLK2 plays a role in Kaposi's sarcoma-associated herpesvirus reactivation.
ASF1 (zeige SRSF1 Antikörper) cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 (zeige SRSF1 Antikörper) and hASF1a (zeige ASF1A Antikörper) by TLK kinases.
TLK1 (zeige TLK1 Antikörper) and TLK2 have largely redundant roles in genome maintenance.
The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.
tousled-like kinase 2
, Serine/threonine-protein kinase tousled-like 2
, serine/threonine kinase
, serine/threonine-protein kinase tousled-like 2
, pKU-alpha protein kinase
, protein kinase U-alpha