anti-Titin (TTN) Antikörper

TTN encodes a large abundant protein of striated muscle. Zusätzlich bieten wir Ihnen Titin Kits (21) und Titin Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
TTN 7273 Q8WZ42
TTN 22138  
TTN 84015  
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Showing 10 out of 57 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IHC, IHC (p) Immunohistochemistry-Paraffin: Titin Antibody  - Staining of human heart muscle shows strong cytoplasmic positivity in myocytes. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
Human Kaninchen Unkonjugiert IF (p), IHC (p) Antigen: 2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Rabbit Anti-Goat IgG at 1: 5000;  TMB staining Read the data in Microplate Reader by 450nm. Formalin-fixed and paraffin embedded rat heart labeled with Anti-Titin/CMD1G Polyclonal Antibody, Unconjugated (ABIN1387283) at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
Human Maus Unkonjugiert IF, IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to TTN on formalin-fixed paraffin-embedded human skeletal muscle. [antibody concentration 1 ug/ml] Detection limit for recombinant GST tagged TTN is approximately 0.03ng/ml as a capture antibody. 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
Human Kaninchen Alexa Fluor 350 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
Human Kaninchen Alexa Fluor 555 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
Human Kaninchen Alexa Fluor 647 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
Human Kaninchen FITC IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
Human Kaninchen Alexa Fluor 488 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
Human Kaninchen Cy7 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
Human Kaninchen HRP IHC (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage

TTN Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Mouse (Murine) , ,
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Rat (Rattus) , ,
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Am meisten referenzierte anti-Titin Antikörper

  1. Human Polyclonal Titin Primary Antibody für IHC, IHC (p) - ABIN4359867 : Seki, Yuasa, Kusumoto, Kunitomi, Saito, Tohyama, Yae, Kishino, Okada, Hashimoto, Takei, Egashira, Kodaira, Kuroda, Tanaka, Okata, Suzuki, Murata, Fujita, Fukuda: Generation and characterization of functional cardiomyocytes derived from human T cell-derived induced pluripotent stem cells. in PLoS ONE 2014 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal Titin Primary Antibody für IF, IHC (p) - ABIN563282 : Choi, Park, Yi, Kim: Novel Mutation of the GNE Gene Presenting Atypical Mild Clinical Feature: A Korean Case Report. in Annals of rehabilitation medicine 2015 (PubMed)

Weitere Antikörper gegen Titin Interaktionspartner

Human Titin (TTN) Interaktionspartner

  1. Exome sequencing was conducted and a novel mutation c.107788T>C (p.W35930R) in the titin gene (TTN) was identified.

  2. Study found that there is a missense mutation in the TTN gene, c.100126A > G (p.Thr33376Ala), in a family whose members suffer from familial dilated cardiomyopathy. TTN is closely related to dilated cardiomyopathy and is an important causative gene of familial dilated cardiomyopathy.

  3. Truncating titin mutations cause a mild and treatable form of dilated cardiomyopathy.

  4. Activation of titin protein represents an initial step forward adaptive remodelling of the exercised muscle and may also be involved in the initiation of myofibre repair.

  5. Novel A178D missense mutation in titin is a cause of a highly penetrant familial cardiomyopathy with features of left ventricular noncompaction.

  6. Quantitative models derived from large-scale human genetic and phenotypic data can be applied to truncating mutations in titin in dilated cardiomyopathy.

  7. Variants near TTN and CCDC8 (zeige CCDC8 Antikörper) were associated with KI67 (zeige MKI67 Antikörper) expression, and rs2288563 and rs2562832 in TTN are potential biomarkers for the prediction of clinical outcomes in hepatitis B-related hepatocellular carcinoma patients.

  8. Recent studies classify pathogenic variants in the TTN gene as the main responsible for Familial Dilated Cardiomyopathy.

  9. Heterozygous loss of RBM20 (zeige RBM20 Antikörper) suffices to profoundly impair myocyte biomechanics by its disturbance of TTN splicing causing dilated cardiomyopathy.

  10. Study identified a probable association between variation in TTN gene and patients with sudden unexpected death syndrome.

Mouse (Murine) Titin (TTN) Interaktionspartner

  1. It is likely that titin plays a role in the increase of active muscle stiffness during rapid unloading. These results are consistent with the idea that, in addition to the thin filaments, titin is activated upon Ca(2 (zeige CA2 Antikörper)+) influx in skeletal muscle.

  2. Titin-based force enhancement in skeletal muscle is essentially absent in muscular dystrophy with myositis sarcomeres where amino acids in N2A and PEVK titin are deleted, indicating these specific regions along titin are paramount in increasing titin stiffness in an active sarcomere.

  3. Our data suggest that Tbeta4 is required for setting correct sarcomere length and for appropriate splicing of titin, not only in the heart but also in skeletal muscle.

  4. Phosphorylating Titin's Cardiac N2B Element by ERK2 (zeige MAPK1 Antikörper) or CaMKIIdelta Lowers the Single Molecule and Cardiac Muscle Force

  5. Cleavage of C-terminal titin by CAPN3 (zeige CAPN3 Antikörper) is associated with limb-girdle muscular dystrophy 2A and tibial muscular dystrophy.

  6. titin affects the tuning of shivering frequency

  7. An increase in the degree of titin phosphorylation results in increased proteolytic degradation of this protein, that contributes to the development of skeletal muscle atrophy.

  8. Pure volume overload induces an increase in titin stiffness that is beneficial and limits eccentric remodeling.

  9. increased titin stiffness promotes myocardial contraction by accelerating the formation of force-generating cross-bridges without decelerating relaxation

  10. alpha-Synemin (zeige SYNM Antikörper) localizes to the M-band of the sarcomere through interaction with the M10 region of titin

Fruit Fly (Drosophila melanogaster) Titin (TTN) Interaktionspartner

  1. Here we show using Drosophila indirect flight muscle that the filamin ortholog Cheerio in conjunction with the giant elastic protein titin plays a crucial role in keeping thin filaments stably anchored at the Z-disc. We identify the filamin domains required for interaction with the titin ortholog Sallimus, and we demonstrate a genetic interaction of filamin with titin and actin.

  2. Sls is a novel hub gene responsible for the regulation of mitochondrial respiration in the muscle sarcomere.

  3. Projectin immunolocalization studies during myofibrillogenesis in Drosophila indirect flight muscles.

  4. Projectin is oriented within the indirect flight muscles sarcomere with its NH2-terminus embedded in the Z-bands. This protein has an elastic region, possibly the PEVK-like domain located close to the NH2-terminus.

  5. Alternative Sls isoforms could regulate the stiffness of the many fibre types in Drosophila muscles.

  6. Results reveal a role for Mlp84B in maintaining muscle structural integrity, and suggest Mlp84B and D-titin cooperate to stabilize muscle sarcomeres.

Cow (Bovine) Titin (TTN) Interaktionspartner

  1. titin may be a factor involved in the Frank-Starling mechanism of the heart by promoting actomyosin interaction in response to stretch

  2. calcium affects passive myocardial tension in a titin isoform-dependent manner.

  3. Upon relaxation of shortened myocytes, the restoring stiffness correlates with the titin isoform expression profile with myocytes that express high levels of the stiff isoform (N2B) having the highest restoring stiffness.

Rabbit Titin (TTN) Interaktionspartner

  1. The results of this study are consistent with the claim that residual force enhancement is present and is regulated by titin in skeletal psoas myofibrils, but not cardiac papillary myofibrils

  2. landscape recovered all features of our nanomechanics results. The ensemble molten-globule dynamics delivers significant added contractility that may assist sarcomere mechanics, and it may reduce the dissipative energy loss associated with titin unfolding/refolding during muscle contraction/relaxation cycles.

  3. Work done by titin protein folding assists muscle contraction.

  4. Suggest that the increase in the static tension in activated striated muscle is directly associated with Ca(2+)-dependent change in titin properties and not associated with changes in titin-actin interactions.

  5. titin's visco-elastic properties appear to depend on the Ig do- main un/refolding kinetics and that indeed, titin (and thus myofibrils) can become virtually elastic when Ig domain un/refolding is prevented.

  6. Under non-equilibrium conditions across the physiological force range, titin extends by a complex pattern of history-dependent discrete conformational transitions.

  7. We tested the hypothesis that titin properties might be reflected well in single myofibrils. mechanics of titin are well preserved in isolated myofibrils.

  8. Titin might be responsible for passive force enhancement observed in myofibrils.

  9. The structure and self-interactive properties of an approximately 290 kDa ( approximately 100 nm long) tryptic fragment from the I-band part of titin that is extensible in situ, is presented.

  10. results suggest residual force enhancement in skeletal muscle fibers is caused by stiffening of titin upon muscle activation but not with titin binding to actin; finding indicates existence of a Ca(2 (zeige CA2 Antikörper)+)-regulated, titin-based stiffness in skeletal muscle

Pig (Porcine) Titin (TTN) Interaktionspartner

  1. Two polymorphisms previously identified and described in the 3'UTR (zeige UTS2R Antikörper) of MYPN (zeige MYPN Antikörper) and TTN genes in a group of Italian Large White (ILW) and Italian Duroc (ID) pigs, were analysed.

  2. Titin-actin interaction: PEVK-actin-based viscosity in a large animal.

  3. Neonatal pig hearts showed large N2BA-titin isoforms distinct from those present in the adult porcine myocardium.

  4. findings demonstrate that Tn plays an important role in the Frank-Starling mechanism of the heart via on-off switching of the thin filament state, in concert with titin-based regulation

  5. Report PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness.

  6. Coexpression of the 2 titin isoforms in large mammals allows longer sarcomere lengths without the development of excessive diastolic tension.

Titin (TTN) Antigen-Profil

Protein Überblick

This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma.

Genbezeichner und Symbole assoziert mit anti-Titin (TTN) Antikörper

  • titin (TTN) Antikörper
  • titin (Ttn) Antikörper
  • bent (bt) Antikörper
  • sallimus (sls) Antikörper
  • titin (titin) Antikörper
  • titin (TTNLOC100620261) Antikörper
  • 0020/01 Antikörper
  • 39c-18 Antikörper
  • 1100001C23Rik Antikörper
  • 2310036G12Rik Antikörper
  • 2310057K23Rik Antikörper
  • 2310074I15Rik Antikörper
  • AF006999 Antikörper
  • anon-CREST Antikörper
  • AV006427 Antikörper
  • Bt Antikörper
  • CG1479 Antikörper
  • CG1915 Antikörper
  • CG10285 Antikörper
  • CG18242 Antikörper
  • CG18245 Antikörper
  • CG18857 Antikörper
  • CG32019 Antikörper
  • CMD1G Antikörper
  • CMH9 Antikörper
  • CMPD4 Antikörper
  • CT3598 Antikörper
  • CT8086 Antikörper
  • CT41299 Antikörper
  • d-titin Antikörper
  • D330041I19Rik Antikörper
  • D830007G01Rik Antikörper
  • Dmel\\CG1915 Antikörper
  • Dmel\\CG32019 Antikörper
  • EOMFC Antikörper
  • HMERF Antikörper
  • ket Antikörper
  • kettin Antikörper
  • KZ Antikörper
  • l(2)2 Antikörper
  • l(2)23 Antikörper
  • l(3)62Ca Antikörper
  • l(3)Ca Antikörper
  • l(3)dre8 Antikörper
  • l(3)j1D7 Antikörper
  • l(3)rL182 Antikörper
  • l(3)S002001 Antikörper
  • l(4)2 Antikörper
  • l(4)21 Antikörper
  • l(4)23 Antikörper
  • l(4)37 Antikörper
  • l(4)38 Antikörper
  • l(4)102CDa Antikörper
  • l(4)PT-2 Antikörper
  • L56 Antikörper
  • LGMD2J Antikörper
  • MCP Antikörper
  • mdm Antikörper
  • MYLK5 Antikörper
  • Prj Antikörper
  • sal Antikörper
  • sam Antikörper
  • shru Antikörper
  • Sls Antikörper
  • Titin Antikörper
  • TMD Antikörper
  • UNC-22 Antikörper

Bezeichner auf Proteinebene für anti-Titin (TTN) Antikörper

connectin , rhabdomyosarcoma antigen MU-RMS-40.14 , C-protein , CG32019-PC , CG32019-PF , CG32019-PH , CG32019-PI , bt-PC , bt-PF , bt-PH , bt-PI , lethal(4) Powell, Tennessee-2 , myosin LCK , projectin , projectin myosin light chain kinase , twitchin , CG1915-PA , CG1915-PD , CG1915-PP , CG1915-PQ , CG1915-PR , CG1915-PS , CG1915-PT , CG1915-PU , CG1915-PV , CG1915-PW , CG1915-PX , CG1915-PY , CG1915-PZ , D-titin , D-titin-KZ , dtitin , kettin , lethal (3) S002001 , lethal(3)62Ca , mitotic chromosomal protein , salimus , sls-PA , sls-PD , sls-PP , sls-PQ , sls-PR , sls-PS , sls-PT , sls-PU , sls-PV , sls-PW , sls-PX , sls-PY , sls-PZ , titin , titin protein homolog

7273 Homo sapiens
22138 Mus musculus
43814 Drosophila melanogaster
44013 Drosophila melanogaster
84015 Rattus norvegicus
424126 Gallus gallus
540561 Bos taurus
1791505 Rhodopirellula baltica SH 1
100008570 Oryctolagus cuniculus
100620261 Sus scrofa
100722767 Cavia porcellus
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