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TBXA2R encodes a member of the G protein-coupled receptor family. Zusätzlich bieten wir Ihnen Thromboxane A2 Receptor Antikörper (43) und Thromboxane A2 Receptor Kits (23) und viele weitere Produktgruppen zu diesem Protein an.
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Thromboxane A2 receptor is expressed in both vagal and spinal neurons. Thromboxane A(2) may elicit stronger vagal or parasympathetic reflexes in the rabbit when released during tissue trauma depending on the location of release.
Data suggest that in hypoxic pulmonary hypertension, loss of site-specific phosphorylation of TBXA2R results in agonist hyper-responsiveness; Ser324 appears to be primary residue phosphorylated during protein kinase A activation of TBXA2R.
Data show that thromboxane A2 receptor beta-isoform (TPbeta) is highly expressed in intrauterine growth restriction (IUGR) placentae but is absent from healthy placentae.
We conclude that hyperglycemia activates thromboxane A2 receptor to impair the integrity and function of blood-brain barrier via the ROCK-PTEN-Akt (zeige AKT1 Proteine)-eNOS (zeige NOS3 Proteine) pathway.
data presented herein propose a novel diagnostic and prognostic potential for TPalpha (zeige HADHA Proteine) and TPbeta in the histopathological assessment of PCa (zeige FLVCR1 Proteine). While TPalpha (zeige HADHA Proteine) and TPbeta are differentially expressed and independently regulated, increased levels of TPbeta, TPalpha (zeige HADHA Proteine) or both correlated with increased risk of recurrence and reduced disease-free survival time.
TBXA2R is a novel breast cancer-associated gene required for the survival and migratory behaviour of a subset of Triple Negative Breast Cancer (TNBC).
TXA2R rs1131882TT genotype is associated with carotid plaque vulnerability, platelet activation and TXA2 levels in ischemic stroke patients.
We demonstrate that Trp334 in the TPbeta C-terminus is critical for the CCT7 (zeige CCT7 Proteine) interaction and plays an important role in TPbeta maturation and cell-surface expression.
TBXA2R +924C/T polymorphism is associated with asthma risk
A considerable portion of Chinese ischemic stroke patients are insensitive to aspirin treatment, which may be correlated with the MDR1 C3435T, TBXA2R (rs1131882), and PLA2G7 (zeige Lp-PLA2 Proteine) (rs1051931-rs7756935) polymorphisms.
Data suggest that thromboxane A2/TBXA2R signaling promotes multiple myeloma cell proliferation by reducing delay at G2/M phase via up-regulation of MAP kinase (zeige MAPK1 Proteine) pathway, up-regulation of cyclin B1 (zeige CCNB1 Proteine)/CDK1 (zeige CDK1 Proteine) expression, and down-regulation of apoptosis.
The results of this study show that TXA2R polymorphisms may affect platelet function and the risk of developing cerebral ischemia.
The results suggest that EP3 (zeige PTGER3 Proteine) along with TP contributes to vasoconstrictor responses evoked by PGI2 (zeige PTGIR Proteine), and hence imply a novel mechanism for endothelial cyclooxygenase metabolites (which consist mainly of PGI2 (zeige PTGIR Proteine)) in regulating vascular functions.
platelet GP6 (zeige GP6 Proteine) and thromboxane A2 receptor have a role in promoting inflammatory macrophage phenotype in skin inflammation
Genetic deletion of thromboxane receptor in adipose-derived stromal cells accelerated endothelial cell differentiation.
PKCalpha (zeige PKCa Proteine) deficiency leads to pulmonary vascular hyperresponsiveness to TXA2, possibly via increased pulmonary arterial TP receptor expression.
Uridine adenosine tetraphosphate induced aortic contraction depends on activation of TX synthase and thromboxane A2 receptor, which partially requires the activation of P2X1R through an endothelium-dependent mechanism.
Blocking the expression of the thromboxane receptor significantly suppresses the prothrombotic effect of C-reactive protein (zeige CRP Proteine).
The thromboxane A(2) receptor agonist 11-deoxy PGF (zeige PTGFR Proteine)(2alpha) can partially alleviate embryo crowding in the Lpar3 (zeige LPAR3 Proteine)((-/-)) females and embryo crowding likely contributes to reduced litter size in the Lpar3 (zeige LPAR3 Proteine)((-/-)) females.
We show here that thromboxane receptor in the striatum locally facilitates dopamine overflow.
thromboxane A2 receptor signalling does not contribute critically to the pathogenesis of ischemic acute kidney injury
Thromboxane A2 receptor activation via PKC-zeta (zeige PRKCZ Proteine)-mediated NAD(P)H (zeige NQO1 Proteine) oxidase activation increases superoxide and peroxynitrite, resulting in eNOS (zeige NOS3 Proteine) uncoupling in endothelial cells.
This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene.
thromboxane A2 receptor
, prostanoid TP receptor
, TXA2 receptor
, thromboxane prostanoid
, Thromboxane receptor