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TAS2R38 encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Zusätzlich bieten wir Ihnen Taste Receptor, Type 2, Member 38 Kits (10) und Taste Receptor, Type 2, Member 38 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal TAS2R38 Primary Antibody für IF (p), IHC (p) - ABIN1385568
Maurer, Wabnitz, Kahle, Stegmaier, Prior, Giese, Gaida, Samstag, Hänsch: Tasting Pseudomonas aeruginosa Biofilms: Human Neutrophils Express the Bitter Receptor T2R38 as Sensor for the Quorum Sensing Molecule N-(3-Oxododecanoyl)-l-Homoserine Lactone. in Frontiers in immunology 2015
Show all 2 Pubmed References
In addition, we found signatures of ancient selective forces acting on different African TAS2R38 haplotypes. Collectively our results provide evidence for a relaxation of recent selective forces acting on this gene and a revised hypothesis for the origins of the present-day worldwide distribution of TAS2R38 haplotypes.
genetic association studies in population of elderly women in Poland: Data suggest that SNPs in TAS2R38 (rs713598, rs1726866, rs10246939) and an SNP in CA6 (zeige CA6 Antikörper) (rs2274333) are associated with intake of and preferences for some foods (coffee and white cabbage) among the population studied. (TAS2R38 = taste receptor type 2 member 38; CA6 (zeige CA6 Antikörper) = carbonic anhydrase VI (zeige CA6 Antikörper))
Despite many other factors influencing food preference and intake in children, actual intake of sweet food items is associated with TAS2R38 genotype. Children with PP or PA genotype consume more (energy dense) sweet tasting foods.
We now describe expression of T2R38 in tumor cells in patients with pancreatic cancer and in tumor-derived cell lines. our data indicate a new, additional function of the taste receptor T2R38 beyond sensing "bitter".
TAS2R38 gene has an impact on phenotypic and clinical outputs affecting obesity, showing significant associations with extreme weight conditions, and changes in both olfactory capacity and immune traits.
This research is the first to demonstrate a relationship between T2R38 bitter taste receptor (zeige TAS2R7 Antikörper) activity (assessed by phenylthiocarbamide taste sensitivity), a genetic trait, and in vitro biofilm formation in clinical isolates recovered from chronic rhinosinusitis patients
T2R38 is thus much more broadly tuned for bacterial compounds than previously thought.
TAS2R38 genotype and 6-n-propylthiouracil sensitivity status revealed high percentage of non-tasters. Food preferences and BMI did not significantly correlate TAS2R38 genotype.
T2R38 is stimulated by acyl-homoserine lactones, gram-negative quorum-sensing molecules, and subsequently activates nitric oxide-dependent innate immune responses. The formation of mature cilia is necessary for T2R38 expression and function, and polymorphisms that underlie T2R38 functionality appear to be involved in susceptibility to upper respiratory infection and recalcitrant CRS (zeige CARS Antikörper).
Genetic Variation in the TAS2R38
This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant).
taste receptor, type 2, member 38
, taste receptor, type 2, member 7-like
, taste receptor type 2 member 38
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, PTC bitter taste receptor
, taste receptor type 2 member 61
, bitter taste receptor TAS2R38