TNF Receptor-Associated Protein 1 Proteine (TRAP1)

TRAP1 encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. Zusätzlich bieten wir Ihnen TNF Receptor-Associated Protein 1 Antikörper (259) und TNF Receptor-Associated Protein 1 Kits (8) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TRAP1 10131 Q12931
TRAP1 68015 Q9CQN1
Ratte TRAP1 TRAP1 287069 Q5XHZ0
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Top TNF Receptor-Associated Protein 1 Proteine auf antikoerper-online.de

Showing 8 out of 10 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
Details
Escherichia coli (E. coli) Human Unkonjugiert 10 μg Anmelden zum Anzeigen 2 bis 3 Tage
$210.00
Details
Escherichia coli (E. coli) Human GST tag TNF Receptor-Associated Protein 1 (TRAP1) (AA 60-308), (partial) protein (GST tag) 1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$1,842.50
Details
Escherichia coli (E. coli) Human GST tag 100 μg Anmelden zum Anzeigen 11 Days
$411.40
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
Escherichia coli (E. coli) Human His tag   100 μg Anmelden zum Anzeigen 15 bis 17 Tage
$899.10
Details
Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$717.00
Details

TRAP1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
, ,
Mouse (Murine)

Weitere Proteine zu TNF Receptor-Associated Protein 1 (TRAP1) Interaktionspartnern

Human TNF Receptor-Associated Protein 1 (TRAP1) Interaktionspartner

  1. Both redox imbalance and IHG-1 stimulate TGF-beta signalling. IHG-1, HSPA5 and YBX1 all show increased expression in diabetic nephropathy, chronic kidney disease and in the Unilateral Ureteral Obstruction model of kidney fibrosis. Increased IHG-1 expression in UUO correlated with loss of TRAP1 expression. IHG-1 may target TRAP1 for degradation.

  2. results show that even though TRAP1 depletion affects both normal MRC-5 and tumour A549 cell proliferation, inhibition of autophagy per se led to a decrease in tumour cell mass, while having a reduced effect on the normal cell line. The strategy of targeting TRAP1 in NSCLC shows future potential therapeutic applications.

  3. Here, the authors show that rather than being cooperative or independent, ATP hydrolysis on the two protomers is sequential and deterministic. Moreover, dimer asymmetry sets up differential hydrolysis rates for each protomer, such that the buckled conformation favors ATP hydrolysis.

  4. TRAP1 inhibition may be regarded as potential strategy to target specific features of human thyroid cancers, i.e., cell proliferation and resistance to apoptosis.

  5. TRAP1 regulates stemness and Wnt/beta-catenin pathway in colorectal cancer.

  6. data show that TRAP1 acts downstream of PINK1 and HTRA2 for mitochondrial fine tuning, whereas TRAP1 loss of function leads to reduced control of energy metabolism, ultimately impacting mitochondrial membrane potential.

  7. This review summarizes how metabolism, chemoresistance, inflammation, and epithelial-to-mesenchymal transition are strictly interconnected, and how TRAP1 stays at the crossroads of these processes, thus shedding new lights on molecular networks at the basis of ovarian cancer. [review]

  8. The crystal structure of a human TRAP1NM dimer is presented, featuring an intact N-domain and M-domain structure, bound to adenosine 5'-beta,gamma-imidotriphosphate.

  9. These data suggest that TRAP1 protein network may provide a prognostic signature in human metastatic colorectal carcinomas

  10. TRAP1 is relevant in the control of key cell cycle regulators in tumor cells. TRAP1/TBP7 quality control of CDK1 and MAD2 contributes mechanistically to the regulation of mitotic entry and transit.

  11. TRAP1 is often deleted in high-grade serous ovarian cancer patients.

  12. TRAP1 increases cell proliferation, reduces apoptosis, and promotes cell invasion without changes in mitochondrial bioenergetics. Therefore, TRAP1 is a driver of prostate cancer in vivo and an "actionable" therapeutic target.

  13. overexpression of TRAP1 might contribute to tumor cell local invasion of colorectal cancer

  14. Increased TRAP1 expression was significantly associated with EOC stages.

  15. Overexpression of TRAP1 in breast cancer cells causes mitochondrial fusion, triggers mitochondria to form tubular networks, and suppresses cell migration and invasion in vitro and in vivo. These data link TRAP1-regulated mitochondrial dynamics and function with tumorigenesis in breast cancer.

  16. TRAP1 is highly expressed in kidney cancer and correlates with patients prognosis

  17. TRAP1 is a downstream effector of BRAF cytoprotective pathway in mitochondria and TRAP1 targeting may represent a novel strategy to improve the activity of proapoptotic agents in BRAF-driven CRC cells.

  18. Our results indicate that GRP94 and TRAP1 might contribute more to the carcinogenesis or biology of SCLC than HSP90alpha and HSP90beta

  19. A previously unobserved coiled-coil dimer conformation may precede dimer closure. TRAP1 exists in an autoinhibited state with the ATP lid bound to the ATP-binding pocket. ATP displaces this and signals the cis-bound ATP status to the next subunit.

  20. results of the present study show that TRAP1 provides cardioprotection against myocardial I/R by ameliorating mitochondrial dysfunction

Mouse (Murine) TNF Receptor-Associated Protein 1 (TRAP1) Interaktionspartner

  1. show that TRAP1 could protect the mitochondrial structure in renal tubular epithelial cells; maintain the levels of mitochondrial membrane potential, ATP, and mitochondrial DNA copy number

  2. TRAP1 increases cell proliferation, reduces apoptosis, and promotes cell invasion without changes in mitochondrial bioenergetics. Therefore, TRAP1 is a driver of prostate cancer in vivo and an "actionable" therapeutic target.

  3. Data show that the overexpression of heat shock protein 75 (Hsp75) decreased neural stem cells (NSCs) apoptosis and preserved mitochondrial membrane potential.

  4. TRAP-1-/- mice are viable and show reduced incidence of age-associated pathologies. Loss of TRAP-1 upregulates oxidative phosphorylation and glycolysis transcriptomes.

  5. overexpression of TRAP1 leads to mitochondrial aberrations, including an increase in basal ROS levels and decrease in mitochondrial biogenesis, together with a decrease in peroxisome proliferator-activated receptor gamma coactivator-1alpha mRNA levels

  6. Early mesangial nephritis initiates a cascade of inflammatory signals that lead to up-regulation of Trap1 and a consequent down-regulation of renal DNaseI by transcriptional interference.

  7. TRAP1 regulates a metabolic switch between oxidative phosphorylation and aerobic glycolysis in immortalized mouse fibroblasts.

  8. These data identify TRAP-1 as a novel mitochondrial survival factor differentially expressed in localized and metastatic prostate cancer compared with normal prostate.

Zebrafish TNF Receptor-Associated Protein 1 (TRAP1) Interaktionspartner

  1. The crystal structure of full-length TRAP1, the mitochondrial Hsp90 molecular chaperone, in a catalytically active closed state is presented.

TNF Receptor-Associated Protein 1 (TRAP1) Protein Überblick

Protein Überblick

This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit TRAP1

  • TNF receptor associated protein 1 (TRAP1)
  • TNF receptor-associated protein 1 (Trap1)
  • TNF receptor-associated protein 1 (TRAP1)
  • TNF receptor associated protein 1 (Trap1)
  • TNF receptor-associated protein 1 (trap1)
  • 2410002K23Rik Protein
  • fc85a11 Protein
  • HSP 75 Protein
  • HSP75 Protein
  • HSP90L Protein
  • TRAP-1 Protein
  • wu:fc85a11 Protein

Bezeichner auf Proteinebene für TRAP1

TNFR-associated protein 1 , heat shock protein 75 kDa, mitochondrial , tumor necrosis factor type 1 receptor-associated protein , HSP 75 , TRAP-1 , tumor necrosis factor type 1 receptor associated protein

GENE ID SPEZIES
10131 Homo sapiens
68015 Mus musculus
287069 Rattus norvegicus
416666 Gallus gallus
514472 Bos taurus
490032 Canis lupus familiaris
100718722 Cavia porcellus
571959 Danio rerio
Ausgewählte Anbieter für TNF Receptor-Associated Protein 1 Proteine (TRAP1)
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