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The protein encoded by TM2D3 contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily.
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Our results establish a rare TM2D3 variant in association with late-onset Alzheimer's disease susceptibility, and together with prior work suggests possible links to the beta-amyloid cascade
Our approach yielded 26 candidate genes differentially expressed between patients (Osteoarthritis) and controls. BLP2 and CIAS1 (zeige NLRP3 Proteine) seem to be trans-regulated, as the absence of allelic expression imbalances suggests.
The protein encoded by this gene contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily. This protein has sequence and structural similarities to the beta-amyloid binding protein (BBP), but, unlike BBP, it does not regulate a response to beta-amyloid peptide. This protein may have regulatory roles in cell death or proliferation signal cascades. Several alternatively spliced transcript variants of this gene are described but the full length nature of some variants has not been determined. Multiple polyadenylation sites have been found in this gene.
TM2 domain-containing protein 3
, TM2 domain containing 3
, BBP-like protein 2
, beta-amyloid-binding protein-like protein 2