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TBX20 encodes a T-box family member. Zusätzlich bieten wir Ihnen TBX20 Proteine (9) und viele weitere Produktgruppen zu diesem Protein an.
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Tbx20 activity needs to be tightly fine-tuned to guarantee regular cardiomyocyte proliferation and embryonic heart growth in vivo.
the identification of a zebrafish tbx20 mutation that results in an inactive, truncated protein lacking any functional domains, is reported.
data demonstrate that elevated glucose alone induces cardiac defects in zebrafish embryos by altering the expression pattern of tbx5 (zeige TBX5 Antikörper), tbx20, and has2 (zeige HAS2 Antikörper) in the heart
embryos lacking hrT function have dysmorphic hearts and an absence of blood circulation
redundant activities of Nkx2.5 and Nkx2.7 are required for cardiac morphogenesis (zeige XIRP1 Antikörper), but Nkx2.7 plays a more critical function, regulating the expressions of tbx5 (zeige TBX5 Antikörper) and tbx20 through the maturation stage
we show that TBX5 (zeige TBX5 Antikörper) and TBX20 can physically interact and map the interaction domains, and we show a cellular interaction for the two proteins in cardiac development
results showed that the TBX20 gene is not the major gene affecting nonsyndromic congenital heart disease development
Collectively, our proteomic, biochemical, genetic, and structural studies suggest that the physical interaction between TBX20 and CASZ1 (zeige CASZ1 Antikörper) is required for cardiac homeostasis, and further, that reduction or loss of this critical interaction leads to dilated cardiomyopathy (DCM)
chromatin analysis reveals that endocardial TBX20 has roles in septation
The current study associated TBX20 haploinefficiency with isolated Dilated cardiomyopathy (DCM), and expanded upon the mutational spectrum of TBX20 associated with DCM and congenital heart disease (CHD (zeige CHDH Antikörper)), which provides novel insight into the molecular mechanism of DCM and CHD (zeige CHDH Antikörper), suggesting potential implications for early personalized treatment of these diseases.
Silencing of TBX20 in rat myocardial and human embryonic kidney cells significantly inhibited cell proliferation, induced cell apoptosis and led to G2/M cell cycle arrest.
rs3999950 may be associated with congenital heart disease, and TBX20 may predispose children to the defect.
Among the 8 SNPs identified, 6 are in strong linkage disequilibrium and the minor alleles are associated with lower CHD (zeige CHDH Antikörper) risk. The minor alleles have lower transcriptional activity than major alleles in both human heart tissues and three cell lines. TBX20 minor alleles may exhibit higher binding affinity with certain transcription repressors.
Cardiac TBX20 expression showed a negative correlation with LVEF and a positive correlation with left ventricular end-systolic volume. No significant difference in TBX20 CNVs and promoter methylation was observed between IDCM patients and control group
The mutation markedly reduced the synergistic activation of TBX20 with NKX2-5 (zeige NKX2-5 Antikörper) or GATA4 (zeige GATA4 Antikörper).
We report three missense mutations (Y309D, T370O, and M395R) within the transcriptional activator domain of human TBX20 that were associated with atrial septal defect
Tbx18 (zeige TBX18 Antikörper) does not function redundantly with Tbx2 (zeige TBX2 Antikörper) or Tbx20 in epicardial development.
Cardiomyocyte Tbx20 induced overexpression activates multiple cardiac proliferative pathways, directly represses cell-cycle inhibitory genes p21 (zeige D4S234E Antikörper), Meis1 (zeige MEIS1 Antikörper), and Btg2 (zeige BTG2 Antikörper), promotes adult CM proliferation; and preserves cardiac performance after MI.
TLE1 (zeige TLE1 Antikörper)/TLE3-NuRD corepressor complex facilitates Tbx20-dependent transcriptional repression.
The effects of Tbx20 are epistatic to Tbx3 (zeige TBX3 Antikörper) in the heart, but Tbx3 (zeige TBX3 Antikörper) is epistatic to Tbx20 with respect to developmental delay.
Tbx20-mediated increases in cell proliferation, providing evidence for parallel regulatory pathways downstream of BMP/Smad1 (zeige SMAD1 Antikörper)/5/8 signaling in promoting cardiomyocyte proliferation after birth
Tbx20 is expressed in the developing endocardial cushions and valves throughout heart development. Ablation of Tbx20 in endocardial cells causes severe valve elongation defects and impaired cardiac function.
a dual role for TBX20 as both a transcriptional activator and a repressor, and that each of these functions regulates genes with very specialized and distinct molecular roles
Data show distinct functions for Tbx20 in regulation of cardiomyocyte lineage maturation and cell proliferation at embryonic and fetal stages of heart development.
This gene encodes a T-box family member. The T-box family members share a common DNA binding domain, termed the T-box, and they are transcription factors involved in the regulation of developmental processes. This gene is essential for heart development. Mutations in this gene are associated with diverse cardiac pathologies, including defects in septation, valvulogenesis and cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, T-box transcription factor 20
, Tbx20-like homeobox protein
, H15-related T-box transcription factor hrT
, T-box protein 20
, T-box transcription factor TBX20