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The product of SSX2 belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. Zusätzlich bieten wir Ihnen Synovial Sarcoma, X Breakpoint 2 Antikörper (64) und Synovial Sarcoma, X Breakpoint 2 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
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Human SSX2 Protein expressed in Wheat germ - ABIN1321452
Smith, Cronk, Lang, McNeel: Expression and immunotherapeutic targeting of the SSX family of cancer-testis antigens in prostate cancer. in Cancer research 2011
We conclude from these findings that SSX2 expression in prostate cancer is not a driver of the epithelial to mesenchymal transition (EMT (zeige ITK Proteine)), but is involved in processes associated with EMT (zeige ITK Proteine) including loss of focal adhesion that may be related to tumor cell dissemination
Meta-analysis of human synovial sarcoma patient series identified two tumor-gentoype-phenotype correlations that were not modeled by the mice, namely a scarcity of male hosts and biphasic histologic features among SS18 (zeige SS18 Proteine)-SSX2 tumors. Re-analysis of human SS18 (zeige SS18 Proteine)-SSX1 (zeige SSX1 Proteine) and SS18 (zeige SS18 Proteine)-SSX2 tumor transcriptomes demonstrated very few consistent differences, but highlighted increased native SSX2 expression in SS18 (zeige SS18 Proteine)-SSX1 (zeige SSX1 Proteine) tumors.
results reveal two important phenotypes of ectopic SSX2 expression that may drive/support tumorigenesis: First, immediate induction of genomic instability, and second, long-term support of tumor cell growth.
The tumor-specific pattern of expression of SSX2.
primary autoantibodies against intracellular MM-specific tumor antigens SSX-2 and NY-ESO-1 (zeige CTAG1B Proteine) are rare but functional in multiple myeloma patients after allogeneic stem cell transplantation
SS18 (zeige SS18 Proteine)-SSX-induced Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling appears to be of crucial biological importance in synovial sarcoma tumorigenesis and progression.
SSX2, SSX3, and SSX4 are expressed in the lung tissue of only 3.5% early-stage non-small cell lung cancer patients.
These results suggest that the characteristic speckle localization pattern of SS18 (zeige SS18 Proteine)-SSX is strongly involved in the tumorigenesis through the SSX moiety of the SS18 (zeige SS18 Proteine)-SSX fusion protein.
the initial events that likely occur when SYT (zeige SS18 Proteine)-SSX2 is first expressed, and its dominant function in subverting the nuclear program of the stem cell, leading to its aberrant differentiation, as a first step toward transformation
The regulation of estrogen receptor alpha (zeige ESR1 Proteine) signaling by target proteins of SSX2 may explain the metastatic potential of breast cancer cells.
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X\\\\;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity. Two transcript variants encoding distinct isoforms have been identified for this gene.
cancer/testis antigen 5.2
, cancer/testis antigen family 5, member 2a
, protein SSX2
, sarcoma, synovial, X-chromosome-related 2
, synovial sarcoma, X breakpoint 2B
, tumor antigen HOM-MEL-40
, synovial sarcoma, X breakpoint 2
, synovial sarcoma, X breakpoint 3
, protein SSX1
, putative protein SSX10
, putative protein SSX6-like