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Sync encodes a member of the intermediate filament family which contains an N-terminal head domain, followed by a central coiled-coil region and a short C-terminal tail. Zusätzlich bieten wir Ihnen Syncoilin Antikörper (19) und Syncoilin Kits (5) und viele weitere Produktgruppen zu diesem Protein an.
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in the liver, syncoilin is predominantly expressed by activated Hepatic stellate cells and displays very low-expression levels in other liver cell types, making it a good marker of activated Hepatic stellate cells.
A neuronal analysis of the syn (zeige PRPH Proteine)coilin-null mouse (Sync(-/-)) revealed a reduced ability in accelerating treadmill and rotarod tests.
The data show that absence of alpha-dystrobrevin (zeige DTNA Proteine) or desmin (zeige DES Proteine) leads to dynamic changes in syncoilin that may compensate for, or participate in, different muscle myopathies.
Syncoilin may play a supportive role for desmin (zeige DES Proteine) in the efficient coupling of mechanical stress between the myofibril and muscle fiber exterior.
A second viable syncoilin knockout model and highlights the importance of further investigations to determine the role of syncoilin in skeletal muscle.
Despite lacking an apparent structural role in striated (zeige NSDHL Proteine) muscle, the three syncoilin isoforms are differentially and strongly upregulated during muscle regeneration and atrophy in C57BL/6 mice, possibly suggesting an atypical role for syncoilin in muscle.
Syncoilin modulates peripherin (zeige PRPH Proteine) filament network formation.
The differences in human syncoilin and beta-synemin (zeige SYNM Proteine) mRNA ratios between Duchenne muscular dystrophy (zeige DMD Proteine) and normal muscles were not statistically significant
the result of this study raise the possibility that mutations in the gene encoding for syncoilin may underlie some forms of muscle disease.
This gene encodes a member of the intermediate filament family which contains an N-terminal head domain, followed by a central coiled-coil region and a short C-terminal tail. The protein is highly expressed in skeletal and cardiac muscle. The protein links the dystrophin associated protein complex (DAPC) to desmin filaments in muscle and may have a structural role in striated muscle. Multiple transcript variants encoding different isoforms have been found for this gene.
syncoilin intermediate filament 1
, intermediate filament protein syncoilin
, syncoilin, intermediate filament 1