anti-Structural Maintenance of Chromosomes Flexible Hinge Domain Containing 1 (SMCHD1) Antikörper

SMCHD1 encodes a protein which contains a hinge region domain found in members of the SMC (structural maintenance of chromosomes) protein family. Zusätzlich bieten wir Ihnen SMCHD1 Kits (4) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SMCHD1 74355 Q6P5D8
SMCHD1 23347 A6NHR9
SMCHD1    
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Top anti-SMCHD1 Antikörper auf antikoerper-online.de

Showing 10 out of 19 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), SimWes, WB Immunohistochemistry-Paraffin: SMCHD1 Antibody [NBP1-82978] - Staining of human testis shows strong nuclear positivity in cells of seminiferus ducts. Simple Western: SMCHD1 Antibody [NBP1-82978] - Simple Western lane view shows a specific band for SMCHD1 in 0.2 mg/ml of U-251MG lysate. This experiment was performed under reducing conditions using the 66-440 kDa separation system. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$494.38
Details
Human Maus Unkonjugiert IHC (p) Immunohistochemistry-Paraffin: SMCHD1 Antibody  - Staining of human endometrium shows nuclear immunoreactivity in glandular cells. Immunohistochemistry-Paraffin: SMCHD1 Antibody  - Staining of human stomach shows nuclear immunoreactivity in glandular cells. 100 μL Anmelden zum Anzeigen 10 bis 13 Tage
$494.38
Details
Human Kaninchen Unkonjugiert IC, IF, WB Immunofluorescent analysis of SMCHD1 staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody Western blot analysis of SMCHD1 expression in SKOV3 (A), Jurkat (B), HepG2 (C), rat brain (D) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert IF/ICC, WB Western blot analysis of extracts of various cell lines, using SMCHD1 antibody (ABIN5974343) at 1/1000 dilution. Immunofluorescence analysis of MCF-7 cells using SMCHD1 antibody (ABIN5974343). Blue: DAPI for nuclear staining. 100 μL Anmelden zum Anzeigen 11 bis 16 Tage
$426.40
Details
Human Kaninchen Unkonjugiert IF, WB Western blot analysis of extracts of various cell lines, using SMCHD1 antibody. Immunofluorescence analysis of MCF-7 cells using SMCHD1 antibody. 200 μL Anmelden zum Anzeigen 12 bis 14 Tage
$438.90
Details
Human Kaninchen Unkonjugiert IF, IHC, WB Western blot analysis of extracts of various cell lines, using SMCHD1 antibody. Immunofluorescence analysis of MCF7 cell using SMCHD1 antibody. Blue: DAPI for nuclear staining. 100 μL Anmelden zum Anzeigen 16 Days
$366.77
Details
Human Kaninchen Unkonjugiert IF, IHC, WB   50 μL Anmelden zum Anzeigen 11 bis 14 Tage
$361.17
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Human Kaninchen Unkonjugiert IF/ICC, WB 100 μL Anmelden zum Anzeigen 11 bis 18 Tage
$369.55
Details
Human Kaninchen Unkonjugiert IHC, IP, WB Western Blot: SMCHD1 Antibody [NBP1-49969] - Detection of Human SmcHD1 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 mcg) cells. Antibodies: Affinity purified rabbit anti-SmcHD1 antibody used for WB at 0.04 mcg/ml (A) and 0.4 mcg/ml (B) and used for IP at 3 mcg/mg lysate. SmcHD1 was also immunoprecipitated by rabbit anti-SmcHD1 antibody which recognizes an upstream epitope. For blotting immunoprecipitated SmcHD1 was used. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 3 seconds (B). 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$559.35
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), IP, WB Western Blot: SMCHD1 Antibody [NBP1-49968] - Detection of Human SmcHD1 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 mcg) cells. Antibodies: Affinity purified rabbit anti-SmcHD1 antibody used for WB at 0.04 mcg/ml (A) and 0.4 mcg/ml (B) and used for IP at 3 mcg/mg lysate. SmcHD1 was also immunoprecipitated by rabbit anti-SmcHD1 antibody which recognizes a downstream epitope. For blotting immunoprecipitated SmcHD1 was used. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 10 seconds (B). 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$559.35
Details

Am meisten referenzierte anti-SMCHD1 Antikörper

  1. Human Polyclonal SMCHD1 Primary Antibody für ICC, IF - ABIN4354780 : Lemmers, Tawil, Petek, Balog, Block, Santen, Amell, van der Vliet, Almomani, Straasheijm, Krom, Klooster, Sun, den Dunnen, Helmer, Donlin-Smith, Padberg, van Engelen, de Greef, Aartsma-Rus, Frants et al.: Digenic inheritance of an SMCHD1 mutation and an FSHD-permissive D4Z4 allele causes facioscapulohumeral muscular dystrophy type 2. ... in Nature genetics 2012 (PubMed)

Weitere Antikörper gegen SMCHD1 Interaktionspartner

Mouse (Murine) Structural Maintenance of Chromosomes Flexible Hinge Domain Containing 1 (SMCHD1) Interaktionspartner

  1. A mutation in SMCHD1 gene reported in both an FSHD2 patient and a BAMS patient results in increased ATPase activity and a smaller Xenopus eye size.

  2. de-repression of X-inactivated genes accompanied a local reduction in the enrichment of Histone3K27me3 in mouse embryonic fibroblasts deficient for SmcHD1.

  3. This study demonstrated that the hinge domain of Smchd1 probably adopts an unconventional homodimeric arrangement augmented by an intermolecular coiled coil formed between the two monomers.

  4. An indirect interaction mediated by the LRIF1 and HP1 proteins loads SMCHD1 onto chromatin marked by trimethylation of histone H3 lysine 9 (H3K9me3).

  5. Data suggest that structural maintenance of chromosomes flexible hinge domain containing 1 (Smchd1) imparts epigenetic regulation via physical association with chromatin.

  6. SmcHD1 is an important regulator of imprinted and clustered genes

  7. Genome-wide expression analysis showed that Smchd1 is required for the silencing of around 10% of the genes on the inactive X chromosome, apparently independent of CpG island hypomethylation, and, moreover, that these genes nonrandomly occur in clusters.

  8. Smchd1-dependent CGI methylation, the primary pathway, is acquired gradually over an extended period, whereas Smchd1-independent CGI methylation occurs rapidly after the onset of X inactivation

  9. Reduced dosage of the modifiers of epigenetic reprogramming Dnmt1, Dnmt3L, SmcHD1 and Foxo3a has no detectable effect on mouse telomere length in vivo.

  10. SmcHD1 is not required for correct Xist expression, but localizes to the inactive X and has a role in the maintenance of X inactivation and the hypermethylation of CpG islands associated with the inactive X.

Human Structural Maintenance of Chromosomes Flexible Hinge Domain Containing 1 (SMCHD1) Interaktionspartner

  1. A mutation in SMCHD1 gene reported in both an FSHD2 patient and a BAMS patient results in increased ATPase activity and a smaller Xenopus eye size.

  2. Regions necessary for SMCHD1 protein nuclear localization, dimerization, and cleavage sites were identified.

  3. we report two Japanese FSHD2 siblings (brother and sister) with a new SMCHD1 nonsense mutation (a heterogeneous c. 1654C>T substitution, leading to a stop codon Arg552 *).

  4. We discuss the involvement of this rearrangement in Facioscapulohumeral dystrophy (FSHD), since all mutations in SMCHD1 are not associated with D4Z4 hypomethylation and do not always segregate with the disease

  5. SMCHD1 acts as a repressor on a limited set of autosomal gene clusters, as an observed reduction in methylation associates with a loss of SMCHD1 binding and increased expression for some of the loci.

  6. We summarise here current understanding of the mechanism of action of SMCHD1, its role in these diseases, and what has been learnt from study of mouse models null for Smchd1 in the decade since the discovery of SMCHD1

  7. Mutations in SMCHD1 thus contribute to distinct phenotypic spectra.

  8. SMCHD1 as a key player in nasal development.

  9. SMCHD1 mutations cause Bosma arhinia microphthalmia syndrome.

  10. Study identified novel SMCHD1 mutations in a Japanese cohort of facioscapulohumeral muscular dystrophy 2 patients, confirming the presence of this disease in a wider population than previously known

  11. This study demonstrated that the the linkage peak revealed a variant (rs574972) within an intron of the gene SMCHD1 is linkaged to major depression in Mexican Americans.

  12. The synergistic effect has been demonstrated of two SMCHD1 variants on D4Z4 hypomethylation site and disease penetrance in facioscapulohumeral muscular dystrophy-2 patients.

  13. In the case of FSHD1, a contraction of the D4Z4 repeat array is disease causing whereas FSHD2 is most often caused by mutations in the structural maintenance of chromosomes hinge domain 1 (SMCHD1) gene.

  14. Two facioscapulohumeral muscular dystrophy type 2 families with a 1.2-Mb deletion encompassing the SMCHD1 gene are described; they have only one copy of SMCHD1.

  15. An indirect interaction mediated by the LRIF1 and HP1 proteins loads SMCHD1 onto chromatin marked by trimethylation of histone H3 lysine 9 (H3K9me3).

  16. findings confirm the role of SMCHD1 mutations in FSHD2 and as a modifier of disease severity.

  17. This approach was successfully employed in the context of the in silico prediction of potential remotely acting regulatory elements for the SMCHD1 gene. Subsequent sequencing of these predicted regions identified three sequence variants in FSHD patients

  18. SmcHD1 is an important regulator of imprinted and clustered genes

  19. SMCHD1 recruitment to DNA damage foci is regulated by 53BP1.

  20. study reports a novel mutation p.Lys275del in SMCHD1 in a family with facioscapulohumeral muscular dystrophy 2; conclude that the SMCHD1 mutation is the likely cause of the disease in this family

SMCHD1 Antigen-Profil

Protein Überblick

This gene encodes a protein which contains a hinge region domain found in members of the SMC (structural maintenance of chromosomes) protein family.

Genbezeichner und Symbole assoziert mit SMCHD1

  • SMC hinge domain containing 1 (Smchd1) Antikörper
  • structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) Antikörper
  • 4931400A14Rik Antikörper
  • AW554188 Antikörper
  • mKIAA0650 Antikörper
  • MommeD1 Antikörper

Bezeichner auf Proteinebene für SMCHD1

structural maintenance of chromosomes flexible hinge domain-containing protein 1 , SMC hinge domain-containing protein 1

GENE ID SPEZIES
74355 Mus musculus
23347 Homo sapiens
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