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Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway.. Zusätzlich bieten wir Ihnen Squalene Epoxidase Antikörper (28) und Squalene Epoxidase Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Taken together, our results support a model whereby the amphipathic helix in squalene monooxygenase N100 attaches reversibly to the ER membrane depending on cholesterol levels; with excess, the helix is ejected and unravels, exposing a hydrophobic patch, which then serves as a degradation signal.
Both HMGCR (zeige HMGCR ELISA Kits) and SQLE promoters have two SREs that may act as a homing region to attract a single SREBP-2 (zeige SREBF2 ELISA Kits) homodimer.
Higher Gleason grade was associated with lower LDLR (zeige LDLR ELISA Kits) expression, lower SOAT1 (zeige SOAT1 ELISA Kits) and higher SQLE expression. Besides high SQLE expression, cancers that became lethal despite primary treatment were characterized by low LDLR (zeige LDLR ELISA Kits) expression (odds ratio for highest versus lowest quintile, 0.37; 95% CI 0.18-0.76) and by low SOAT1 (zeige SOAT1 ELISA Kits) expression (odds ratio, 0.41; 95% CI 0.21-0.83).
Data indicate that microRNA miR (zeige MLXIP ELISA Kits)-133b-dependent squalene epoxidase (SQLE) plays a critical role in the potential metastasis mechanisms in esophageal squamous cell carcinoma (ESCC).
our results pinpoint SQLE as a bona fide metabolic oncogene (zeige RAB1A ELISA Kits) by amplification, and as a therapeutic target in BC. These findings could have implications in other cancer types.
this study have identified a Squalene Monooxygenase region integrally associated with the endoplasmic reticulum membrane that is likely to interact with cholesterol or respond to cholesterol-induced membrane effects.
overexpression of SQLE in HCC (zeige FAM126A ELISA Kits) cells promoted cell proliferation and migration, while downregulation of SQLE inhibited the tumorigenicity of Hepatocellular carcinoma cells in vitro and in vivo.
Data suggest that unsaturated fatty acids (oleate; oleoyl-CoA) stabilize SM/SQLE (which catalyzes 1st oxygenation step in cholesterol synthesis) most likely via inhibition of poly-ubiquitination by MARCH6 (membrane-associated ring finger (zeige PCGF1 ELISA Kits) [C3HC4] 6).
MARCH6 and squalene monooxygenase (SM) physically interact, and consistent with MARCH6 acting as an E3 ligase, its overexpression reduces SM abundance in a RING-dependent manner.
A cDNA library consisting of 220 upregulated genes in tumour tissue was established and named as LSCC. Differential expression was confirmed in five of these genes, including IGFBP5 (zeige IGFBP5 ELISA Kits), SQLE, RAP2B (zeige RAP2B ELISA Kits), CLDN1 (zeige CLDN1 ELISA Kits), and TBL1XR1 (zeige TBL1XR1 ELISA Kits).
Squalene epoxidase is a strong positional candidate gene for obesity, using squantitative trait locus studies.
results demonstrate critical dependence of a 205 bp region for sterol dependent regulation of squalene epoxidase & uncover a possible framework for SREBP-promoter interaction, including a potent synergy with NF-Y that may be of principal importance.
Requires a redox partner, but cytochrome p450 reductase (zeige POR ELISA Kits) is not the only microsomal reductase that will serve this purpose.
Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway.
, squalene monooxygenase