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Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Zusätzlich bieten wir Ihnen Spi-C Transcription Factor (Spi-1/PU.1 Related) Antikörper (22) und Spi-C Transcription Factor (Spi-1/PU.1 Related) Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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These results indicate a novel role for Spi-C as a negative regulator of B cell development and function.
Study reports that Spic regulated the development of F4/80(+)VCAM1 (zeige VCAM1 Proteine)(+) bone marrow macrophages (BMM) and that Spic expression in BMM and red pulp macrophages development was induced by heme, a metabolite of erythrocyte degradation.
Regulation of follicular B cell differentiation by the related E26 transformation-specific transcription factors PU.1, Spi-B (zeige SPIB Proteine), and Spi-C.
The Kit-activating mutations cooperate with Spi-1 (zeige SPI1 Proteine)/PU.1 overexpression to promote tumorigenic progression during erythroleukemia in mice.
Spi-C has the potential to modulate PU.1 activity to promote B cell differentiation.
data indicate that ectopic expression of Spi-C can impair B-cell development and function by affecting genes associated with BCR (zeige BCR Proteine) signaling
Spi-C controls development of red pulp macrophages required for red blood cell recycling and iron homeostasis
A protein interaction between SPI-C and STAT6 (zeige STAT6 Proteine) is the basis for a novel mechanism for regulation of IL4 (zeige IL4 Proteine) induced gene expression.
Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity).
Spi-C transcription factor (Spi-1/PU.1 related)
, serine (or cysteine) proteinase inhibitor, clade B, member 6c
, serine proteinase inhibitor member 6C
, transcription factor Spi-C
, pu.1-related factor