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May have a role in the regulation of spermatogenesis.. Zusätzlich bieten wir Ihnen SPATA2 Antikörper (47) und und viele weitere Produktgruppen zu diesem Protein an.
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Zebrafish spata2 is expressed at early developmental stages.
SPATA2 has been described as a previously unrecognized factor in the linear ubiquitin chain assembly complex-dependent signaling pathways that serves as an adaptor between HOIP (zeige RNF31 Proteine) and CYLD (zeige CYLD Proteine), thereby enabling recruitment of CYLD (zeige CYLD Proteine) to signaling complexes.
The data reveal SPATA2 as a high-affinity binding partner of CYLD (zeige CYLD Proteine) and HOIP (zeige RNF31 Proteine), and a regulatory component of linear ubiquitin chain assembly complex-mediated NF-kappaB (zeige NFKB1 Proteine) signaling.
this study identifies SPATA2 as an important factor in the TNF (zeige TNF Proteine) signaling pathway with a substantial role for the effects mediated by the cytokine.
The predicted PUB domain in the N-terminus of SPATA2 interacts with the USP domain of CYLD and SPATA2 is required for recruitment of CYLD to the TNF-alpha receptor-associated signaling complexes.
The aim of this study was to investigate whether the HCP5, TNIP1 (zeige TNIP1 Proteine), TNFAIP3 (zeige TNFAIP3 Proteine), SPATA2 and COG6 (zeige COG6 Proteine) genes were genetic risk factors for psoriasis in Chinese population.
PD-L1 (zeige CD274 Proteine) is highly expressed in tumours rather than tumour-free lymph nodes, which is closely correlated with the impairment of IFN-gamma (zeige IFNG Proteine) production of tumour-infiltrating T-cells.
Tumor-infiltrating NY-ESO-1 (zeige CTAG1B Proteine)-specific CD8 (zeige CD8A Proteine)+ T cells are negatively regulated by LAG-3 (zeige LAG3 Proteine) and PD-1 (zeige PDCD1 Proteine) in human ovarian cancer.
disappearance of TLD (zeige BMP1 Proteine) epitope reactivity from an otherwise stable EBV-specific response reflects selective loss of cognate antigen restimulation, not IL-7 (zeige IL7 Proteine)-dependent signals, and is immediately preceded by PD-1 (zeige PDCD1 Proteine) upregulation to unprecedented levels.
Our data revealed the impact of SPATA2 on male fertility and suggested that SPATA2 ensures the normal secretory function of Sertoli cells
Spata2 can regulate inflammatory response and cell death in both RIPK1 (zeige RIPK1 Proteine)-dependent and RIPK1 (zeige RIPK1 Proteine)-independent manners
May have a role in the regulation of spermatogenesis.
spermatogenesis associated protein 2
, spermatogenesis-associated protein 2
, spermatogenesis associated PD1
, spermatogenesis-associated protein PD1