anti-Speckle-Type POZ Protein (SPOP) Antikörper

SPOP encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins.

Alle Antikörper anzeigen Gen GeneID UniProt
Anti-Human SPOP SPOP 8405 O43791
Anti-Maus SPOP SPOP 20747 Q6ZWS8
Anti-Ratte SPOP SPOP 287643  
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Top anti-Speckle-Type POZ Protein Antikörper auf antikoerper-online.de

Showing 10 out of 69 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-SPOP Antibody Titration:  0.2-1 ug/ml  Positive Control:  HepG2 cell lysate SPOP is supported by BioGPS gene expression data to be expressed in HepG2 Host:  Rabbit  Target Name:  SPOP  Sample Tissue:  Human MCF7  Antibody Dilution:  1.0ug/ml 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB Western blot analysis of SPOP expression in HepG2 (A), Hela (B), NIH3T3 (C) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert IHC, WB WB Image Sample (50 ug of whole cell lysate) A: mouse brain 10% SDS PAGE antibody diluted at 1:2000 WB Image Sample (30 ug of whole cell lysate) A: 293T 10% SDS PAGE antibody diluted at 1:1000 100 μL Anmelden zum Anzeigen 1 bis 2 Tage
$358.60
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Huhn Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
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Human Kaninchen Unkonjugiert WB SPOP Antibody (N-term) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the SPOP antibody detected the SPOP protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$507.83
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Human Kaninchen Unkonjugiert ELISA, WB 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$446.88
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Human Huhn Unkonjugiert WB 0.05 mg Anmelden zum Anzeigen 2 bis 3 Tage
$481.25
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Human Huhn Unkonjugiert WB 0.05 mg Anmelden zum Anzeigen 2 bis 3 Tage
$481.25
Details
Human Kaninchen Unkonjugiert WB Western Blot: SPOP Antibody [NBP2-20477] - Sample (30 ug of whole cell lysate) A: HCT116 10% SDS PAGE gel, diluted at 1:1000. 0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$514.63
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Weitere Antikörper gegen Speckle-Type POZ Protein Interaktionspartner

Xenopus laevis Speckle-Type POZ Protein (SPOP) Interaktionspartner

  1. Dzip1 (zeige DZIP1 Antikörper)-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli (zeige GLI1 Antikörper)/Ci proteins in the Hh pathway.

Human Speckle-Type POZ Protein (SPOP) Interaktionspartner

  1. Expression of the F133V mutation and wild-type SPOP was at much lower levels compared to that of F102C and Y87N mutations; however, at present, it is unknown if this also affects the biological activity of the SPOP protein.

  2. PD-L1 (zeige CD274 Antikörper) protein abundance is regulated by cyclin D-CDK4 (zeige CDK4 Antikörper) and the cullin 3 (zeige CUL3 Antikörper)-SPOP E3 ligase via proteasome-mediated degradation

  3. methylation status of SPOP promoter can be used as a novel epigenetic biomarker and a therapeutic target in colorectal cancer.

  4. these data highlight SPOP as an important regulator of luminal epithelial cell proliferation and c-MYC (zeige MYC Antikörper) expression in prostate physiology, identify c-MYC (zeige MYC Antikörper) as a novel bona fide SPOP substrate, and help explain the frequent inactivation of SPOP in human prostate adenocarcinoma.

  5. Results elucidate the tumor-suppressor role of SPOP in prostate cancer in which it acts as a negative regulator of BET protein stability and also provide a molecular mechanism for resistance to BET inhibitors in individuals with prostate cancer bearing SPOP mutations.

  6. SPOP mutation in endometrial cancer increased degradation of BRD2 (zeige BRD2 Antikörper), BRD3 (zeige BRD3 Antikörper) and BRD4 (zeige BRD4 Antikörper) proteins. SPOP mutation in prostate cancer increased expression of BRD2 (zeige BRD2 Antikörper), BRD3 (zeige BRD3 Antikörper) and BRD4 (zeige BRD4 Antikörper) proteins.

  7. Prostate cancer-derived SPOP mutants failed to interact with Cdc20 (zeige CDC20 Antikörper) to promote its degradation. As a result, SPOP-deficient prostate cancer cells with elevated Cdc20 (zeige CDC20 Antikörper) expression became resistant to a pharmacological Cdc20 (zeige CDC20 Antikörper) inhibitor.

  8. While wild-type SPOP localizes to liquid nuclear speckles, self-association-deficient SPOP mutants have a diffuse distribution in the nucleus. SPOP oligomerizes through its BTB and BACK domains.

  9. SPOP mutation activates both PI3K (zeige PIK3CA Antikörper)/mTOR (zeige FRAP1 Antikörper) and androgen receptor (zeige AR Antikörper) signaling, effectively uncoupling the normal negative feedback between these two pathways.

  10. SPOP-containing complex regulates SETD2 (zeige SETD2 Antikörper) stability and H3K36me3-coupled alternative splicing.

Mouse (Murine) Speckle-Type POZ Protein (SPOP) Interaktionspartner

  1. loss of Spop, but not Spopl (zeige SPOPL Antikörper), disrupts chondrocyte hypertrophy and osteoblast differentiation in the mouse, suggesting the requirement for Spop-mediated protein degradation in mouse skeletal development; overexpressed Spop targets both Gli3FL (zeige GLI3 Antikörper) and Gli3R for ubiquitination and degradation and Spop is an important positive regulator of Ihh (zeige IHH Antikörper) signaling and skeletal development

  2. Results demonstrate a negative role of Spop in the level and activity of Gli3 (zeige GLI3 Antikörper), Shh (zeige SHH Antikörper) signaling and ventral spinal cord patterning.

  3. Speckle-type pox virus and zinc finger (POZ) protein (SPOP) regulates endometrial stromal cell decidualization in mice and that hormones regulate the expression of SPOP. This study suggests that ubiquitination may be involved in embryonic implantation.

  4. These results implicate SPOP as a novel participant in DNA double strand break repair and suggest that SPOP mutation drives prostate tumorigenesis in part through genomic instability.

  5. miR (zeige MLXIP Antikörper)-145 has a role in post-transcriptional regulation of SPOP expression in selected tissues.

  6. Dzip1 (zeige DZIP1 Antikörper)-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli (zeige GLI1 Antikörper)/Ci proteins in the Hh pathway.

  7. similar S/T-rich motifs are present in Gli (zeige GLI1 Antikörper) proteins as well as in numerous HIB-interacting proteins and mediate Gli (zeige GLI1 Antikörper) degradation by SPOP

  8. MacroH2A1.2 (zeige H2AFY Antikörper) binds the nuclear protein (zeige HEMGN Antikörper) Spop.

  9. Interaction of endogenous PDX-1 (zeige PDX1 Antikörper) and PCIF1 in MIN6 insulinoma (zeige RPS15 Antikörper) cells, is demonstarted.

Speckle-Type POZ Protein (SPOP) Antigen-Profil

Protein Überblick

This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.

Genbezeichner und Symbole assoziert mit SPOP

  • speckle type POZ protein (spop) Antikörper
  • speckle type BTB/POZ protein (SPOP) Antikörper
  • Speckle-type POZ protein (Bm1_45730) Antikörper
  • speckle-type POZ protein (spop) Antikörper
  • speckle type POZ protein S homeolog (spop.S) Antikörper
  • speckle-type POZ protein (Spop) Antikörper
  • speckle type BTB/POZ protein (Spop) Antikörper
  • AI315626 Antikörper
  • BTBD32 Antikörper
  • Pcif1 Antikörper
  • spop Antikörper
  • TEF2 Antikörper
  • zgc:64140 Antikörper

Bezeichner auf Proteinebene für SPOP

speckle-type POZ protein , Speckle-type POZ protein , speckle-type POZ protein-like , HIB homolog 1 , SPOP1 , speckle-type POZ protein B , roadkill homolog 1 , PDX-1 C-terminal-interacting factor 1

GENE ID SPEZIES
394599 Xenopus (Silurana) tropicalis
455106 Pan troglodytes
699711 Macaca mulatta
6104034 Brugia malayi
100390371 Callithrix jacchus
100021911 Monodelphis domestica
100056116 Equus caballus
100195374 Salmo salar
100544737 Meleagris gallopavo
100587478 Nomascus leucogenys
100005514 Danio rerio
779391 Xenopus laevis
425528 Gallus gallus
8405 Homo sapiens
480548 Canis lupus familiaris
530618 Bos taurus
20747 Mus musculus
287643 Rattus norvegicus
100343929 Oryctolagus cuniculus
100713182 Cavia porcellus
101111300 Ovis aries
100173908 Pongo abelii
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