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SNX4 encodes a member of the sorting nexin family.
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Results indicate that SNX4-mediated regulation of the steady-state levels and trafficking of BACE1 (zeige BACE Proteine), as well as the subsequent increase in BACE1 (zeige BACE Proteine)-mediated cleavage, may be relevant to Alzheimer's disease progression.
alpha-taxilin interacts with SNX4 and plays a role in the recycling pathway of TfnR.
SNX4, but not SNX1 and SNX8, is associated with the Rab11-recycling endosomes and that a high frequency of SNX4-mediated tubule formation is observed as endosomes undergo Rab4-to-Rab11 transition.
Sorting nexin 4 and amphiphysin 2 (zeige BIN1 Proteine) have roles in endocytosis and intracellular trafficking
study indicates that hVps34 (zeige PIK3C3 Proteine) and its product PI(3 (zeige PI3 Proteine))P are involved in endosome to Golgi transport of ricin, and that SNX2 (zeige SNX2 Proteine) and SNX4 are likely to be effectors in this pathway
by driving membrane tubulation, SNX4 coordinates iterative, geometric-based sorting of the TfnR with the long-range transport of carriers from early endosomes to the ERC (zeige ERC1 Proteine)
clathrin serving as a regulator of SNX4-dependent transport; upon clathrin release, dynein may bind SNX4 and mediate retrograde movement
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene.
, sorting nexin 4
, sorting nexin-4-like
, potential endosome sorting nexin Snx4p