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SNX12 encodes a member of the sorting nexin family. Zusätzlich bieten wir Ihnen Sorting Nexin 12 Antikörper (60) und viele weitere Produktgruppen zu diesem Protein an.
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SNX12 plays a key role in intraluminal vesicle formation and in the maturation of a subpopulation of early endosomes into late endosomes, thereby regulating selective endocytic transport of cargo for degradation.
SNX12 protein level is dramatically decreased in the brain of Alzheimer's disease patients as compared to that of controls.
find that overexpression of SNX12 restores the sorting process in an Hrs knockdown background. Altogether, our data show that despite lower expression level, SNX12 shares redundant functions with SNX3 (zeige SNX3 Proteine) in the biogenesis of multivesicular endosomes
Metallothionein (zeige MT Proteine) deficient mice have a marked decrease in Snx12 during acute lung injury
These results suggest that SNX12 regulates neurite formation during cerebral cortical development.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. A similar protein in mouse may be involved in regulating the neurite outgrowth. Alternate splicing results in multiple transcript variants.
sorting nexin 12
, Sorting nexin 12
, sorting nexin-12