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SNX1 encodes a member of the sorting nexin family. Zusätzlich bieten wir Ihnen Sorting Nexin 1 Antikörper (106) und Sorting Nexin 1 Kits (8) und viele weitere Produktgruppen zu diesem Protein an.
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SNX1 was down-regulated in CRC (zeige CALR Proteine) and associated with poor prognosis. Our data also showed that SNX1 inhibited the proliferation of CRC (zeige CALR Proteine) cells and increased the sensitivity to the most commonly used drugs for CRC (zeige CALR Proteine).
miR (zeige MLXIP Proteine)-95 functions as an oncogene (zeige RAB1A Proteine) role in non-small cell lung cancer cells by directly targeting SNX1.
Results show that suppression of EGFR (zeige EGFR Proteine) membrane recycling by SNX1 appears to be critical for the activation of EGFR (zeige EGFR Proteine) /PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) signaling pathway in human lung cancer cells.
we suggest that SNX1 is involved in the negative regulation of ligand-induced EGFR (zeige EGFR Proteine) phosphorylation and mediates EGFR (zeige EGFR Proteine)/pEGFR trafficking out of early endosomes
SNX1 has a crucial role in D(5)R trafficking and SNX1 depletion results in D(5)R dysfunction and thus may represent a novel mechanism for the pathogenesis of essential hypertension
This study found that significant evidence of association with SNX1 (VEGAS p = 0.035) in patient with Alzheimer disease.
SNX4, but not SNX1 and SNX8, is associated with the Rab11-recycling endosomes and that a high frequency of SNX4-mediated tubule formation is observed as endosomes undergo Rab4-to-Rab11 transition.
Results demonstrate that miR (zeige MLXIP Proteine)-95 increases proliferation by directly targeting SNX1, defining miR (zeige MLXIP Proteine)-95 as a new oncogenic miRNA in CRC (zeige CALR Proteine).
SNX1 and SNX2 interact with Kalirin-7. Overexpression of SNX1 or SNX2 and Kalirin-7 partially redistributes both SNXs to the plasma membrane, and results in RhoG-dependent lamellipodia formation.
These data describe a novel function of SNX1 in the regulation of P2Y(1) receptor recycling and suggest that SNX1 plays multiple roles in endocytic trafficking of G-protein coupled receptors.
SNX1 interacts with Arf6 (zeige ARF6 Proteine) to mediate neurite formation which is regulated by EFA6A (zeige PSD Proteine).
A RUN Domain from DENND5/Rab6IP1 binds sorting Nexin 1 and is involved in the trafficking of vesicles at the level of Golgi.
show that mice lacking sorting nexin 1 or sorting nexin 2 (zeige SNX2 Proteine) are viable and fertile, whereas embryos deficient in both proteins arrest at midgestation.
HkRP1 is involved in the process of tubulation of sorting nexin-1 positive membranes from early endosome subdomains
Data describe a functional interaction between Hbeta58, sorting nexin 1 (SNX1), and SNX2 (zeige SNX2 Proteine) and strongly suggest that SNX2 (zeige SNX2 Proteine) plays a more critical role than SNX1 in retromer activity during embryonic development.
overexpression of FAB1A-GFP reassembles SNX2b-mRFP on the endosomal membrane despite the absence of SNX1.
A loss of FAB1 function causes the release of late endosomal proteins, Ara7, and SNX1 from the endosome membrane, indicating that FAB1, or its product PtdIns(3,5)P2, mediates the maturation process of the late endosomes.
High temperature selectively promotes the retrieval of PIN2 (zeige TERF1 Proteine) from late endosomes and sorts them to the plasma membrane through an endosomal trafficking pathway dependent on SORTING NEXIN1.
Our results reveal a role of SNX1 for the correct trafficking of IRT1 (zeige PARP3 Proteine) and, thus, for modulating the activity of the iron uptake machinery
SNX1 phosphorylation is required for Arabidopsis seedling growth.
the microtubule-associated protein (zeige FAM82A2 Proteine) CLASP (zeige CLASRP Proteine) interacts with the retromer component sorting nexin 1 (SNX1) to mediate an association between endosomes and microtubules.
A combination of immunoelectron and fluorescence microscopy show that sorting nexin 1 (SNX1)localize to the trans-Golgi network (TGN (zeige TG Proteine)), which is considered to represent the early endosome of plants.
Arabidopsis thaliana SORTING NEXIN 1 (AtSNX1) is involved in the auxin pathway and that PIN2 (zeige TERF1 Proteine), but not PIN1 or AUX1, is transported through AtSNX1-containing endosomes [AtSNX1]
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms.
sorting nexin 1
, nexin 1
, sorting nexin-1
, Sorting nexin-1
, sorting nexin 1A