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SLC8A3 encodes a member of the sodium/calcium exchanger integral membrane protein family. Zusätzlich bieten wir Ihnen Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 3 Antikörper (53) und viele weitere Produktgruppen zu diesem Protein an.
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In the discovery phase, 60 loci not previously associated with rheumatoid arthritis risk showed evidence for association and were tested for replication in the validation cohort. A total of 12 loci were replicated at the nominal level. When combining the discovery and validation cohorts, an intronic SNP in SLC8A3 was found to be associated with ACPA (zeige PRTN3 Proteine)-positive rheumatoid arthritis at a genome-wide level of significance.
Ayloid beta mediates calpain cleavage of NCX3 in Alzheimer's disease brain.
NCX1 (zeige SLC8A1 Proteine) and NCX3 -represent two promising druggable targets for setting on new strategies in stroke therapy.
NCX (zeige TLX2 Proteine) isoforms (NCX2, NCX3) contribute to mitochondrial Na(+)/Ca(2 (zeige CA2 Proteine)+) exchange in human DAergic neurons and may act downstream of PINK1 (zeige PINK1 Proteine) in the prevention of neurodegeneration by m[Ca(2 (zeige CA2 Proteine)+)] accumulation.
the large cytosolic loop of NCX1 (zeige SLC8A1 Proteine), NCX2, and NCX3 is involved in acquisition of immunosuppressive drug specificity
Functional studies, as well as mRNA and protein expression analyses, revealed that NCX1 and NCX3, but not NCX2, were divergently modulated during OPC differentiation into oligodendrocyte.
human macrophages and monocytes express NCX1 (zeige SLC8A1 Proteine) and NCX3 that operate in a bidirectional manner to restore [Ca(2 (zeige CA2 Proteine)+)](i) to generate Ca(2 (zeige CA2 Proteine)+) signals and to induce TNF-alpha (zeige TNF Proteine) production.
calcium signaling mediated by NCX3 has a crucial role in oligodendrocyte maturation and myelin formation.
Human platelets express K(+) -independent Na(+) /Ca(2 (zeige CA2 Proteine)+) exchangers NCX1.3, NCX3.2 and NCX3.4.
Data suggest that NCX (zeige TLX2 Proteine)-mediated Ca(2 (zeige CA2 Proteine)+) fluxes normally exist in human ASM (zeige SMPD1 Proteine) (potentially contributing to rapid Ca(2 (zeige CA2 Proteine)+) fluxes), and contribute to enhanced [Ca(2 (zeige CA2 Proteine)+)](i) regulation in airway inflammation.
This study demonstrate that knocking-out NCX3 impairs oligodendrocyte response and worsens clinical symptoms in EAE without altering the immune T-cell population.
Demonstrate that NCX3 genetic deletion protects against ziram-induced neurotoxicity and suggest NCX3 and its downstream molecular pathways as key factors involved in ziram toxicity.
NCX3 regulates mitochondrial calcium handling from the outer mitochondrial membrane through an AKAP121 (zeige AKAP1 Proteine)-anchored signaling complex.
Function and regulation of the Na+-Ca2+ exchanger (zeige SLC8A1 Proteine) NCX3 splice variants in brain and skeletal muscle.
the use of genetic-modified mice for NCX1 (zeige SLC8A1 Proteine), NCX2, and NCX3 represents a fruitful strategy to characterize the physiological role exerted by NCX (zeige SLC8A1 Proteine) in CNS
the solution structure of NCX3 calcium binding domain 2B
Results show that glucocorticoid treatment blunts LPS (zeige TLR4 Proteine)-induced increase in [Ca(2 (zeige CA2 Proteine)+)](i) in dendritic cells by increasing expression and activity of Na(+)/Ca(2 (zeige CA2 Proteine)+) exchanger NCX3.
The deletion of the NCX3 gene has detrimental consequences on basal synaptic transmission, long term potentiation regulation, spatial learning, and memory performance.
This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Three mammalian isoforms in family 8 have been identified. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described.
solute carrier family 8 (sodium-calcium exchanger), member 3
, solute carrier family 8 member 3
, solute carrier family 8 (sodium/calcium exchanger), member 3
, sodium/calcium exchanger 3-like
, Na(+)/Ca(2+)-exchange protein 3
, Na+/Ca2+ exchanger 3
, sodium/calcium exchanger 3
, sodium/calcium exchanger SLC8A3
, sodium-calcium exchanger