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Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Zusätzlich bieten wir Ihnen SLC7A8 Antikörper (48) und viele weitere Produktgruppen zu diesem Protein an.
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The detergent-induced stabilization of the purified human 4F2hc (zeige SLC3A2 Proteine)-LAT2 (zeige LAT2 Proteine) complex presented here paves the way towards its crystallization and structure determination at high-resolution
LAT2 (zeige LAT2 Proteine) genes may play important roles in leiomyoma cell proliferation and regulate leiomyoma growth
LAT1 (zeige LAT Proteine) and LAT2 (zeige LAT2 Proteine) were overexpressed in both pheochromocytoma and medullary thyroid carcinoma by comparison with normal tissues.
LAT1 (zeige LAT Proteine) and LAT2 (zeige LAT2 Proteine) are present and functional in the syncytiotrophoblast MVM, whereas LAT2 (zeige LAT2 Proteine) is also expressed in the BM and in the fetal capillary endothelium.
Compared with the adult cerebral cortex, mRNAs encoding OATP1A2, OATP1C1 (zeige SLCO1C1 Proteine), OATP3A1 (zeige SLCO3A1 Proteine) variant 2, OATP4A1, LAT2 (zeige LAT2 Proteine) and CD98 (zeige SLC3A2 Proteine) were reduced in fetal cortex at different gestational ages, whilst mRNAs encoding MCT8 (zeige MCT8 Proteine), MCT10, OATP3A1 (zeige SLCO3A1 Proteine) variant 1 and LAT1 (zeige LAT Proteine) were similar.
the interaction of CD98 (zeige SLC3A2 Proteine)/LAT2 (zeige LAT2 Proteine) with ICAM-1 (zeige ICAM1 Proteine), found to be expressed to the basolateral domain, and the potential of such interaction on intracellular signal activation in Caco2-BBE (zeige ENO3 Proteine) cell monolayers
identify LAT1 (zeige LAT Proteine) and LAT2 (zeige LAT2 Proteine) as members of system L that mediate transmembrane movement of l-CSNO
Genetic variation in LAT1 (zeige LAT Proteine) and LAT2 (zeige LAT2 Proteine) does not appear to be a major cause of inter-individual variability in pharmacokinetics and of adverse reactions to melphalan.
distinct molecular LAT2-features determine bidirectional amino acid transport but only an unidirectional thyroid hormone (zeige PTH Proteine) import.
Circulating thyroid hormones, thyrotropin and thyroid hormone-responsive (zeige THRSP Proteine) genes remained unchanged in Slc7a8(-/-) mice, possibly because of functional compensation by the thyroid hormone (zeige PTH Proteine) transporter Mct8 (zeige MCT8 Proteine), which is co-expressed in many cell types
the aromatic amino acid diffusion pathway TAT1 can control neutral amino acid efflux via neighboring exchanger LAT2-4F2hc (zeige SLC3A2 Proteine), by recycling its aromatic influx substrates
The positive effect of non-T cell activation linker (NTAL (zeige LAT2 Proteine)) on Akt (zeige AKT1 Proteine) phosphorylation and mast cell survival requires LAT (zeige LAT Proteine).
LAT1 (zeige SLC7A5 Proteine), and LAT2 mRNAs were detected in fetal and postnatal femurs and in MC3T3-E1 cells, while OATP1 and NTCP (zeige SLC10A1 Proteine) mRNAs were not.
Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney (By similarity).
L-type amino acid transporter 2
, integral membrane protein E16H
, large neutral amino acids transporter small subunit 2
, solute carrier family 7 (amino acid transporter, L-type), member 8
, solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
, cationic amino acid transporter y+ system
, solute carrier family 7 member 8
, glycoprotein-associated amino acid transporter LAT2
, solute carrier family 8 (cationic amino acid transporter, y+ system), member 7
, solute carrier family 7 (amino acid transporter light chain, L system), member 8