Sodium Dependent Vitamin C Transporter 1 Proteine (SVCT1)

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters.

alle Proteine anzeigen Gen GeneID UniProt
Human SVCT1 SVCT1 9963 Q9UHI7
Maus SVCT1 SVCT1 20522 Q9Z2J0
Ratte SVCT1 SVCT1 50621 Q9WTW7
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Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
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Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
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Weitere Proteine zu Sodium Dependent Vitamin C Transporter 1 (SVCT1) Interaktionspartnern

Human Sodium Dependent Vitamin C Transporter 1 (SVCT1) Interaktionspartner

  1. Our findings show, for the first time, that transporters of the water-soluble vitamin ascorbic acid (i.e., the vitamin C transporters SVCT-1 and SVCT-2 (zeige SLC23A2 Proteine)) are differentially expressed along the length of the intestinal tract and that the pattern of expression is mediated, at least in part, by transcriptional and epigenetic mechanism(s) affecting both Slc23a1 (zeige SLC23A2 Proteine) and Slc23a2 (zeige SLC23A2 Proteine) genes.

  2. consensus site for HNF1 (zeige HNF1A Proteine) that is crucial for the regulation of the human SVCT1 promoter is present in the SVCT1 rat promoter but has no effect on its transcriptional activity

  3. SNP rs6596473 of SLC23A1 is suggested to be associated with AgP. results add to previous reports vitamin C plays a role in pathogenesis of periodontitis.

  4. Data from observational/genetic association studies in Europe suggest an SNP in SLC23A1 (zeige SLC23A2 Proteine) (rs33972313) is associated with up-regulation of circulating L-ascorbic acid but not with any cardiometabolic/cardiovascular outcome investigated. [META-ANALYSIS]

  5. The SVCT1 was induced and localized to the apical membrane of tubular epithelial cells.

  6. polymorphisms in SLC23A1 (zeige SLC23A2 Proteine)/2 genes influenced ascorbate concentration in aqueous humor and lens nucleus.

  7. A genetic variant in the SLC23A1 (zeige SLC23A2 Proteine) ascorbate transporter locus was identified and is associated with an increased risk of Crohn disease in a white Canadian inflammatory bowel diseases cohort.

  8. Data show that the mRNA level of svct2 (zeige SLC23A2 Proteine) was approximately 600- to 900-fold higher than that of svct1 indicating SVCT2 (zeige SLC23A2 Proteine) is a main isoform in fibroblast OUMS-36 cells, and no significant difference in svct2 (zeige SLC23A2 Proteine) mRNA and protein between young and old cells.

  9. Data suggest that N-terminal and C-terminal sorting signals interact, directly or indirectly, within each gene family (here, SVCT1 and SVCT2 (zeige SLC23A2 Proteine)) in basolateral targeting of transmembrane proteins to basolateral cell membrane.

  10. SVCT1 directly interacts with GRHPR (zeige GRHPR Proteine).

Mouse (Murine) Sodium Dependent Vitamin C Transporter 1 (SVCT1) Interaktionspartner

  1. Aging modulates vitamin C transporter expression. Renal over-expression of SVCT1 enhances vitamin C reabsorption in aged animals that may synthesize less vitamin C.

  2. The SVCT1 was induced and localized to the apical membrane of tubular epithelial cells.

  3. a key role for Slc23a1 in renal ascorbate absorption and perinatal survival and reveal regulation of vitamin C biosynthesis in mice.

  4. By using primary cultured hepatocytes from SMP30/GNL (zeige RGN Proteine) KO mice, we found that SVCT1 and SVCT2 (zeige SLC23A2 Proteine) mRNA expression levels and AA uptake ability were significantly enhanced in the hepatocytes of ascorbic acid-depleted SMP30/GNL (zeige RGN Proteine) KO mice.

  5. SVCT2 (zeige SLC23A2 Proteine) is major determinant of ascorbate accumulation in tissues lacking SVCT1. SVCT isoforms appear to function independently of one another. SVCT1 expression and ascorbate concentrations in SVCT1-predominant organs were not affected by SVCT2 (zeige SLC23A2 Proteine) deficiency.

  6. SVCT1 is responsible for epidermal ascorbic acid supply, whereas SVCT2 (zeige SLC23A2 Proteine) mainly facilitates ascorbic acid transport in the dermal compartment

  7. PPARalpha (zeige PPARA Proteine) up-regulates the expression of Slc23a1 in small intestine.

Sodium Dependent Vitamin C Transporter 1 (SVCT1) Protein Überblick

Protein Überblick

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit SVCT1

  • solute carrier family 23 member 1 (SLC23A1)
  • solute carrier family 23 (nucleobase transporters), member 1 (Slc23a1)
  • solute carrier family 23 member 1 (Slc23a1)
  • D18Ucla2 Protein
  • Slc23a2 Protein
  • SVCT1 Protein
  • YSPL3 Protein

Bezeichner auf Proteinebene für SVCT1

Na(+)/L-ascorbic acid transporter 1 , hSVCT1 , sodium-dependent vitamin C transporter 1 , sodium-dependent vitamin C transporter-1 , solute carrier family 23 (nucleobase transporters), member 1 , solute carrier family 23 (nucleobase transporters), member 2 , solute carrier family 23 member 1 , yolk sac permease-like molecule 3 , sodium-coupled ascorbic acid transporter 1 , sodium-coupled ascorbic acid transporter 1

GENE ID SPEZIES
9963 Homo sapiens
20522 Mus musculus
50621 Rattus norvegicus
396578 Sus scrofa
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