Sodium Dependent Vitamin C Transporter 1 Proteine (SVCT1)

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. Zusätzlich bieten wir Ihnen Sodium Dependent Vitamin C Transporter 1 Antikörper (29) und Sodium Dependent Vitamin C Transporter 1 Kits (6) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SVCT1 9963 Q9UHI7
SVCT1 20522 Q9Z2J0
Ratte SVCT1 SVCT1 50621 Q9WTW7
Direkt bei antikoerper-online bestellen
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Online bestellen
  • orders@antikoerper-online.de

Top Sodium Dependent Vitamin C Transporter 1 Proteine auf antikoerper-online.de

Showing 3 out of 3 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,262.31
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$7,493.38
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details

SVCT1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu Sodium Dependent Vitamin C Transporter 1 (SVCT1) Interaktionspartnern

Human Sodium Dependent Vitamin C Transporter 1 (SVCT1) Interaktionspartner

  1. Our findings show, for the first time, that transporters of the water-soluble vitamin ascorbic acid (i.e., the vitamin C transporters SVCT-1 and SVCT-2) are differentially expressed along the length of the intestinal tract and that the pattern of expression is mediated, at least in part, by transcriptional and epigenetic mechanism(s) affecting both Slc23a1 and Slc23a2 genes.

  2. consensus site for HNF1 that is crucial for the regulation of the human SVCT1 promoter is present in the SVCT1 rat promoter but has no effect on its transcriptional activity

  3. SNP rs6596473 of SLC23A1 is suggested to be associated with AgP. results add to previous reports vitamin C plays a role in pathogenesis of periodontitis.

  4. Data from observational/genetic association studies in Europe suggest an SNP in SLC23A1 (rs33972313) is associated with up-regulation of circulating L-ascorbic acid but not with any cardiometabolic/cardiovascular outcome investigated. [META-ANALYSIS]

  5. The SVCT1 was induced and localized to the apical membrane of tubular epithelial cells.

  6. polymorphisms in SLC23A1/2 genes influenced ascorbate concentration in aqueous humor and lens nucleus.

  7. A genetic variant in the SLC23A1 ascorbate transporter locus was identified and is associated with an increased risk of Crohn disease in a white Canadian inflammatory bowel diseases cohort.

  8. Data show that the mRNA level of svct2 was approximately 600- to 900-fold higher than that of svct1 indicating SVCT2 is a main isoform in fibroblast OUMS-36 cells, and no significant difference in svct2 mRNA and protein between young and old cells.

  9. Data suggest that N-terminal and C-terminal sorting signals interact, directly or indirectly, within each gene family (here, SVCT1 and SVCT2) in basolateral targeting of transmembrane proteins to basolateral cell membrane.

  10. SVCT1 directly interacts with GRHPR.

  11. These findings show a role for Rab8a in the physiological function of SVCT1 in intestinal epithelia.

  12. glutathione depletion failed to affect ascorbic acid transport, and SVCT1 and SVCT2 expression in hepatoma cells. Therefore, our data indicate an essential role for glutathione in controlling vitamin C metabolism in rat hepatocytes and rat hepatoma cells

  13. In patients with hepatocellular cholestasis, primary biliary cirrhosis, haemochromatosis and non-alcoholic steatohepatitis, using real-time RT-PCR, an enhanced hepatic expression of both SLC23A1 and SLC23A2 was found.

  14. hSVCT1 and 2 promoters establish that ascorbic acid uptake by human liver epithelial cells is adaptively regulated and show that transcriptional mechanisms via HNF-1 in the hSVCT1 promoter may, in part, be involved in this regulation.

  15. A genetic variant (rs33972313) in the SLC23A1 vitamin C active transporter locus was identified that is reliably associated with circulating concentrations of L-ascorbic acid in the general population.

  16. SVCT1 is the transporter that allows vectorial uptake of ascorbic acid in differentiated CaCo-2 cells

  17. Results provide the first direct resolution of functional hSVCT1 expression at the apical cell surface of polarized epithelia and define an apical targeting signal of relevance to transporters of diverse substrate specificity.

  18. Functionally, SVCT1 expression led to more transport activity from the apical membrane, while SVCT2 expression only increased the uptake under the condition when basolateral membrane was exposed.

  19. Findings link genetic variants in the vitamin C transporter gene SLC23A1 to spontaneous preterm birth.

  20. C uptake is increased in UVB-irradiated keratinocytes through the translocation of SVCT-1 and regulates inflammatory response in the skin via the downregulation of IL-8 and MCP-1 production

Mouse (Murine) Sodium Dependent Vitamin C Transporter 1 (SVCT1) Interaktionspartner

  1. Aging modulates vitamin C transporter expression. Renal over-expression of SVCT1 enhances vitamin C reabsorption in aged animals that may synthesize less vitamin C.

  2. The SVCT1 was induced and localized to the apical membrane of tubular epithelial cells.

  3. a key role for Slc23a1 in renal ascorbate absorption and perinatal survival and reveal regulation of vitamin C biosynthesis in mice.

  4. By using primary cultured hepatocytes from SMP30/GNL KO mice, we found that SVCT1 and SVCT2 mRNA expression levels and AA uptake ability were significantly enhanced in the hepatocytes of ascorbic acid-depleted SMP30/GNL KO mice.

  5. SVCT2 is major determinant of ascorbate accumulation in tissues lacking SVCT1. SVCT isoforms appear to function independently of one another. SVCT1 expression and ascorbate concentrations in SVCT1-predominant organs were not affected by SVCT2 deficiency.

  6. SVCT1 is responsible for epidermal ascorbic acid supply, whereas SVCT2 mainly facilitates ascorbic acid transport in the dermal compartment

  7. PPARalpha up-regulates the expression of Slc23a1 in small intestine.

  8. This work describe the molecular identity of the transporters involved in vitamin C transport in Sertoli cells.

Sodium Dependent Vitamin C Transporter 1 (SVCT1) Protein Überblick

Protein Überblick

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit SVCT1

  • solute carrier family 23 member 1 (SLC23A1)
  • solute carrier family 23 (nucleobase transporters), member 1 (Slc23a1)
  • solute carrier family 23 member 1 (Slc23a1)
  • D18Ucla2 Protein
  • Slc23a2 Protein
  • SVCT1 Protein
  • YSPL3 Protein

Bezeichner auf Proteinebene für SVCT1

Na(+)/L-ascorbic acid transporter 1 , hSVCT1 , sodium-dependent vitamin C transporter 1 , sodium-dependent vitamin C transporter-1 , solute carrier family 23 (nucleobase transporters), member 1 , solute carrier family 23 (nucleobase transporters), member 2 , solute carrier family 23 member 1 , yolk sac permease-like molecule 3 , sodium-coupled ascorbic acid transporter 1 , sodium-coupled ascorbic acid transporter 1

GENE ID SPEZIES
9963 Homo sapiens
20522 Mus musculus
50621 Rattus norvegicus
396578 Sus scrofa
Ausgewählte Anbieter für Sodium Dependent Vitamin C Transporter 1 Proteine (SVCT1)
Haben Sie etwas anderes gesucht?