Soc-2 Suppressor of Clear Homolog (C. Elegans) Proteine (SHOC2)

SHOC2 encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. Zusätzlich bieten wir Ihnen Soc-2 Suppressor of Clear Homolog (C. Elegans) Antikörper (70) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SHOC2 56392 O88520
Ratte SHOC2 SHOC2 309548 Q6AYI5
SHOC2 8036 Q9UQ13
Direkt bei antikoerper-online bestellen
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Online bestellen
  • orders@antikoerper-online.de

Top Soc-2 Suppressor of Clear Homolog (C. Elegans) Proteine auf antikoerper-online.de

Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$888.80
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details

SHOC2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , ,
, ,

Weitere Proteine zu Soc-2 Suppressor of Clear Homolog (C. Elegans) (SHOC2) Interaktionspartnern

Mouse (Murine) Soc-2 Suppressor of Clear Homolog (C. Elegans) (SHOC2) Interaktionspartner

  1. Results provide evidence that SHOC2 trapping at different subcellular sites has a diverse impact on ERK signaling strength and dynamics, suggesting a dual counteracting modulatory role of SHOC2 in the control of ERK signaling exerted at different intracellular compartments.

  2. Data suggest that SUR-8 may act in an ERK-independent pathway to regulate AVC development.

  3. Erbin has a regulatory role in the Ras-Raf-MEK pathway and may inhibit ERK activation by disrupting the Sur-8-Ras/Raf interaction

Human Soc-2 Suppressor of Clear Homolog (C. Elegans) (SHOC2) Interaktionspartner

  1. Overexpression or knockdown of Sur8 increases or decreases, respectively, the proliferation or transformation of colorectal cancer (CRC) cell lines. Sur8 knockdown attenuates the migration and invasion of HCT116 CRC cells.

  2. Results provide evidence that SHOC2 trapping at different subcellular sites has a diverse impact on ERK signaling strength and dynamics, suggesting a dual counteracting modulatory role of SHOC2 in the control of ERK signaling exerted at different intracellular compartments.

  3. results demonstrate that PSMC5 is a new and important player involved in regulating ERK1/2 signal transmission through the remodeling of Shoc2 scaffold complex in a spatially-defined manner.

  4. Noonan-like syndrome has been related to the invariant c.4A > G missense change in SHOC2.

  5. Two unrelated Taiwanese patients have been described with Noonan-like syndrome with loose anagen hair who also have moyamoya disease and in whom heterozygous germline mutation in SHOC2 was found.

  6. ectopic overexpression of human Shoc2 in PC12 cells significantly promotes neurite extension in the presence of Epidermal Growth Factor, a stimulus that induces proliferation rather than differentiation in these cells.

  7. Extreme phenotypic variability associated with the invariant SHOC2 c.4A>G (p.Ser2Gly) missense mutation in Noonan-like syndrome with loose anagen hair.

  8. A newborn heterozygous for the invariant c.4A>G missense change in SHOC2.

  9. Data show that both Shoc2 and HUWE1 are necessary to control the levels and ubiquitination of the Shoc2 signaling partner, RAF-1.

  10. Both MRAS and SHOC2 play a key role in polarized migration.

  11. SHOC2 and CRAF mediate ERK1/2 reactivation in mutant NRAS-mediated resistance to RAF inhibitor.

  12. targeting of Shoc2 to late endosomes may facilitate EGFR-induced ERK activation under physiological conditions of cell stimulation by EGF, and therefore, may be involved in the spatiotemporal regulation of signaling through the RAS-RAF module

  13. The p.Ser2Gly mutation demonstrated introduction of an N-myristoylation site, resulting in aberrant membrane targeting of SHOC2 and impaired translocation to the nucleus upon growth factor stimulation.

  14. 92 patients with Noonan syndrome and related disorders to characterize mutations in the SHOC2 gene were analysed.

  15. Results indicate that the Shoc2 scaffold protein modulates Ras-dependent Raf1 activation in a Ca(2+)- and calmodulin-dependent manner.

  16. Data suggest that Shoc2 regulates the spatio-temporal patterns of the Ras-ERK signaling pathway primarily by accelerating the Ras-Raf interaction.

  17. no evidence of leukemogenic SHOC2 involvement in juvenile myelomonocytic leukemia

  18. Erbin has a regulatory role in the Ras-Raf-MEK pathway and may inhibit ERK activation by disrupting the Sur-8-Ras/Raf interaction

  19. Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair.

Soc-2 Suppressor of Clear Homolog (C. Elegans) (SHOC2) Protein Überblick

Protein Überblick

This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair.

Genbezeichner und Symbole assoziert mit SHOC2

  • soc-2 (suppressor of clear) homolog (C. elegans) (Shoc2)
  • SHOC2 leucine-rich repeat scaffold protein (Shoc2)
  • SHOC2 leucine-rich repeat scaffold protein S homeolog (shoc2.S)
  • SHOC2, leucine rich repeat scaffold protein (SHOC2)
  • SHOC2 leucine-rich repeat scaffold protein (shoc2)
  • AU017287 Protein
  • mKIAA0862 Protein
  • si:ch211-159c12.3 Protein
  • si:ch211-197i12.3 Protein
  • SIAA0862 Protein
  • SOC2 Protein
  • SUR8 Protein
  • zgc:152956 Protein

Bezeichner auf Proteinebene für SHOC2

Ras-binding protein SUR-8 , leucine-rich repeat protein SHOC-2 , protein soc-2 homolog , protein sur-8 homolog , suppressor of clear, C. elegans, homolog of , Protein soc-2 homolog , Protein sur-8 homolog

GENE ID SPEZIES
56392 Mus musculus
309548 Rattus norvegicus
380042 Xenopus laevis
8036 Homo sapiens
511417 Bos taurus
423894 Gallus gallus
477819 Canis lupus familiaris
555476 Danio rerio
Ausgewählte Anbieter für Soc-2 Suppressor of Clear Homolog (C. Elegans) Proteine (SHOC2)
Haben Sie etwas anderes gesucht?