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SHOC2 encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions.
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Human Polyclonal SHOC2 Primary Antibody für ICC, IF - ABIN4356990
Yi, Chen, Wu, Yang, Xu, Zhuang, Han, Xu: Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development. in Developmental dynamics : an official publication of the American Association of Anatomists 2010
Results provide evidence that SHOC2 trapping at different subcellular sites has a diverse impact on ERK (zeige EPHB2 Antikörper) signaling strength and dynamics, suggesting a dual counteracting modulatory role of SHOC2 in the control of ERK (zeige EPHB2 Antikörper) signaling exerted at different intracellular compartments.
Data suggest that SUR-8 may act in an ERK (zeige EPHB2 Antikörper)-independent pathway to regulate AVC development.
Erbin (zeige ERBB2IP Antikörper) has a regulatory role in the Ras-Raf (zeige RAF1 Antikörper)-MEK (zeige MDK Antikörper) pathway and may inhibit ERK (zeige EPHB2 Antikörper) activation by disrupting the Sur-8-Ras/Raf (zeige RAF1 Antikörper) interaction
Overexpression or knockdown of Sur8 increases or decreases, respectively, the proliferation or transformation of colorectal cancer (CRC (zeige CALR Antikörper)) cell lines. Sur8 knockdown attenuates the migration and invasion of HCT116 CRC (zeige CALR Antikörper) cells.
results demonstrate that PSMC5 (zeige PSMC5 Antikörper) is a new and important player involved in regulating ERK1/2 signal transmission through the remodeling of Shoc2 scaffold complex in a spatially-defined manner.
Noonan-like syndrome has been related to the invariant c.4A > G missense change in SHOC2.
Two unrelated Taiwanese patients have been described with Noonan-like syndrome with loose anagen hair who also have moyamoya disease and in whom heterozygous germline mutation in SHOC2 was found.
ectopic overexpression of human Shoc2 in PC12 cells significantly promotes neurite extension in the presence of Epidermal Growth Factor (zeige EGF Antikörper), a stimulus that induces proliferation rather than differentiation in these cells.
Extreme phenotypic variability associated with the invariant SHOC2 c.4A>G (p.Ser2Gly) missense mutation in Noonan-like syndrome with loose anagen hair.
A newborn heterozygous for the invariant c.4A>G missense change in SHOC2.
Data show that both Shoc2 and HUWE1 (zeige HUWE1 Antikörper) are necessary to control the levels and ubiquitination of the Shoc2 signaling partner, RAF-1 (zeige RAF1 Antikörper).
Both MRAS (zeige MRAS Antikörper) and SHOC2 play a key role in polarized migration.
This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair.
Ras-binding protein SUR-8
, leucine-rich repeat protein SHOC-2
, protein soc-2 homolog
, protein sur-8 homolog
, suppressor of clear, C. elegans, homolog of
, Protein soc-2 homolog
, Protein sur-8 homolog