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SIRT7 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Zusätzlich bieten wir Ihnen Sirtuin 7 Antikörper (173) und Sirtuin 7 Proteine (15) und viele weitere Produktgruppen zu diesem Protein an.
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Authors evaluated the expression of known targets of miR (zeige MLXIP ELISA Kits)-125a and found that sirtuin-7, matrix metalloproteinase-11 (zeige MMP11 ELISA Kits), and c-Raf (zeige RAF1 ELISA Kits) were up-regulated in tumor tissue by 2.2-, 3-, and 1.7-fold, respectively. Overall, these data support a tumor suppressor role for miR (zeige MLXIP ELISA Kits)-125a.
We found a negative correlation between mRNA levels of SIRT1 (zeige SIRT1 ELISA Kits) in VAT of obese individuals and SIRT7 in VAT of the normal-weight subjects and expression of the relevant miRNAs.
Data indicate the role of SIRT7 in inhibiting SMAD4 (zeige SMAD4 ELISA Kits)-mediated breast cancer metastasis providing a possible therapeutic avenue.
Energy stress strengthens SIRT7-mediated effects on Akt (zeige AKT1 ELISA Kits) dephosphorylation.
The SIRT7 is mobilized from the nucleolus to the nucleoplasm and promotes DDB1 deacetylation, leading to decreased DDB1-CUL4 association and CRL4 activity.
Data suggest that SIRT7 undergoes Lys-63 polyubiquitination, later removed by USP7 to repress enzymatic activity of SIRT7; USP7 and SIRT7 regulate gluconeogenesis via expression of glucose-6-phosphatase catalytic subunit (G6PC); SIRT7 targets G6PC promoter through ELK4. (SIRT7 = sirtuin 7; USP7 = ubiquitin specific peptidase 7; G6PC = glucose-6-phosphatase catalytic subunit; ELK4 = transcription factor ELK4)
the decline in SIRT7 in lung fibroblasts has a profibrotic effect, which is mediated by changes in Smad3 (zeige SMAD3 ELISA Kits) levels.
SIRT7 inhibits TR4 degradation by deacetylation of DDB1.
miR (zeige MLXIP ELISA Kits)-152/SIRT7 axis plays a key role in the regulation of Human dental pulp stem cell senescence.
our study suggests that SIRT7 functions as an oncogene (zeige RAB1A ELISA Kits) in non-small cell lung cancer (NSCLC), and miR (zeige MLXIP ELISA Kits)-3666 can target SIRT7 to inhibit NSCLC cell growth by promoting the pro-apoptotic signaling pathway
the results of our study suggest that SIRT7 is involved in protecting neurons against OGD (zeige FGFR1 ELISA Kits)/R-induced injury, possibly through regulation of the p53 (zeige TP53 ELISA Kits)-mediated proapoptotic signaling pathway, indicating a potential therapeutic target for cerebral ischemia/reperfusion injury.
Histological analysis revealed that there is no apparent structural abnormality of the amygdala and hippocampus, which are regions involved in fear memory consolidation, in Sirt7 KO mice. Our results indicate that SIRT7 is involved in the consolidation of fear memory.
Data suggest that high-fat diet (HFD) alters regulation of expression of sirtuins (Sirt4 (zeige SIRT4 ELISA Kits) and Sirt7) and enzymes in NAD biosynthetic pathway (Tdo2 (zeige TDO2 ELISA Kits) and Nnmt (zeige NNMT ELISA Kits)); these alterations are more prominent in liver as compared to white adipose tissue or skeletal muscle; Tdo2 (zeige TDO2 ELISA Kits) and Nnmt (zeige NNMT ELISA Kits) may serve as markers of HFD consumption. (Tdo2 (zeige TDO2 ELISA Kits) = tryptophan 2,3-dioxygenase (zeige TDO2 ELISA Kits); Nnmt (zeige NNMT ELISA Kits) = nicotinamide N-methyltransferase (zeige NNMT ELISA Kits))
The Sirt7 mediates heterochromatin formation at rRNA genes through recruitment of DNA methyltransferase 1 (zeige DNMT1 ELISA Kits) and another member of the sirtuin (zeige SIRT1 ELISA Kits) family, Sirt1 (zeige SIRT1 ELISA Kits).
These results reveal a direct role for SIRT7 in double-strand break repair and establish a functional link between SIRT7-mediated histone H3 (zeige HIST3H3 ELISA Kits) K18 (zeige KRT18 ELISA Kits) deacetylation and the maintenance of genome integrity.
miR (zeige MLXIP ELISA Kits)-93 inhibits the metabolic target Sirt7, which we identified as a major driver of in vivo adipogenesis via induction of differentiation and maturation of early adipocyte precursors.
The role of SIRT7 has emerged in protein synthesis, chromatin remodelling, cellular survival and lipid metabolism.
SIRT7 stabilizes and activates the GABP alpha (zeige GABPA ELISA Kits)/GABPbeta complex via deacetylation of GABPbeta1.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae)
, sirtuin 7
, novel protein similar to vertebratesirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae) (SIRT7)
, NAD-dependent deacetylase sirtuin-7
, NAD-dependent protein deacetylase sirtuin-7
, SIR2-like protein 7
, regulatory protein SIR2 homolog 7
, silent mating type information regulation 2, S.cerevisiae, homolog 7
, sir2-related protein type 7
, sirtuin type 7
, NAD-dependent deacetylase sirtuin 7