Sirtuin 6 Proteine (SIRT6)

SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Zusätzlich bieten wir Ihnen Sirtuin 6 Antikörper (218) und Sirtuin 6 Kits (18) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SIRT6 50721 P59941
SIRT6 51548 Q8N6T7
SIRT6 299638  
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Top Sirtuin 6 Proteine auf antikoerper-online.de

Showing 10 out of 20 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,960.83
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,960.83
Details
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$338.33
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 19 Tage
$583.00
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$345.00
Details
Escherichia coli (E. coli) Ratte His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$720.00
Details
Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$576.00
Details
Escherichia coli (E. coli) Human His tag   10 μg Anmelden zum Anzeigen 2 bis 3 Tage
$245.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$554.07
Details
Escherichia coli (E. coli) Human His tag   100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$512.00
Details

SIRT6 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,

Human , , , ,
, ,
Rat (Rattus)

Am meisten referenzierte Sirtuin 6 Proteine

  1. Human SIRT6 Protein expressed in Wheat germ - ABIN1320053 : Palmer, Fullston, Mitchell, Setchell, Lane: SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity. in Reproduction, fertility, and development 2011 (PubMed)

Weitere Proteine zu Sirtuin 6 (SIRT6) Interaktionspartnern

Mouse (Murine) Sirtuin 6 (SIRT6) Interaktionspartner

  1. Sirt6 inhibits Notch1 (zeige NOTCH1 Proteine) and Notch4 (zeige NOTCH4 Proteine) transcription by deacetylating histone H3K9.

  2. Sirt6 is downregulated in induced pluripotent stem cells from old mice.

  3. post-translational modification facilitates the mobilization of SIRT6 to DNA damage sites and is required for efficient recruitment of poly (ADP-ribose) polymerase 1 (PARP1 (zeige PARP1 Proteine)) to DNA break sites and for efficient repair of double-strand break.

  4. SIRT6 and its downstream signaling could be targeted in Alzheimer's disease and age-related neurodegeneration.

  5. These findings reveal a crucial role of SIRT6 in adipogenesis and provide potential therapeutic targets for obesity.

  6. Global and endothelium-specific SIRT6 knockout mice exhibited impaired endothelium-dependent vasorelaxation. Moreover, SIRT6(+/-) haploinsufficient mice fed a high-fat diet (HFD) also displayed impaired endothelium-dependent vasorelaxation. Importantly, SIRT6(+/-); ApoE(-/-) mice after HFD feeding had exacerbated atherosclerotic lesion development, concurrent with increased expression of proinflammatory cytokine VCAM-1.

  7. these data provide compelling evidence that Sirt6 is important for podocyte homeostasis and maintenance of glomerular function

  8. The mice with SIRT6 deficiency in muscle displayed impaired glucose homeostasis and insulin (zeige INS Proteine) sensitivity, attenuated whole body energy expenditure, and weakened exercise performance. Results from both gain- and loss-of-function experiments identify SIRT6 as a physiological regulator of muscle mitochondrial function.

  9. Study investigated the involvement of SIRT6 in adult hippocampal neurogenesis. Mice over-expressing Sirt6 exhibit increased numbers of young neurons and decreased numbers of mature neurons, without affecting glial differentiation.

  10. Sirt6 deletion in macrophages promoted the activation of nuclear factor-kappaB (NF-kappaB (zeige NFKB1 Proteine)) and endogenous production of interleukin-6 (zeige IL6 Proteine), which led to STAT3 (zeige STAT3 Proteine) activation and the positive feedback circuits for NF-kappaB (zeige NFKB1 Proteine) stimulation; this cross talk expedited an M1 polarization

Human Sirtuin 6 (SIRT6) Interaktionspartner

  1. this study not only suggests potential roles of SIRT6 in regulating apoptosis and stress resistance via direct deacetylation of p53 (zeige TP53 Proteine), but also provides lead compound for the development of potent and selective SIRT6 inhibitors.

  2. in vitro and in vivo studies showed that gene silencing of SIRT6 suppressed cell proliferation and promoted cellular apoptosis by activating the Bax (zeige BAX Proteine)-dependent apoptotic signal pathway in Hepatocellular Carcinoma cells. Furthermore, SIRT6 knockdown could increase liver cancer cell sensitivity to chemotherapy drug doxorubicin. SIRT6 is an important protumorigenic factor in liver carcinogenesis.

  3. SIRT6 is upregulated in non-small cell lung cancer; it may have a functional role in promoting migration and invasion through ERK1/2/MMP9 (zeige MMP9 Proteine) signaling

  4. Sirt6 inhibits Notch1 (zeige NOTCH1 Proteine) and Notch4 (zeige NOTCH4 Proteine) transcription by deacetylating histone H3K9.

  5. These data provide the first evidence of the Egt ability to interfere with endothelial senescence linked to hyperglycaemia through the regulation of SIRT1 (zeige SIRT1 Proteine) and SIRT6 signaling, thus further strengthening the already assessed role of these two histone deacetylases in type 2 diabetes.

  6. Study shows that SIRT6 protein levels are lower in patients with prediabetes (PreDM) and type 2 diabetes mellitus (T2DM) and implies that SIRT6 may take play in development T2DM by altering the expression of genes involved in glucose metabolism through histone modification rather than its role in DNA repair.

  7. Low SIRT6 expression is associated with bone marrow metastasis in neuroblastoma (zeige ARHGEF16 Proteine).

  8. SIRT6 overexpression suppresses PI3K (zeige PIK3CA Proteine) signaling.

  9. post-translational modification facilitates the mobilization of SIRT6 to DNA damage sites and is required for efficient recruitment of poly (ADP-ribose) polymerase 1 (PARP1 (zeige PARP1 Proteine)) to DNA break sites and for efficient repair of double-strand break.

  10. SIRT6 and its downstream signaling could be targeted in Alzheimer's disease and age-related neurodegeneration.

Cow (Bovine) Sirtuin 6 (SIRT6) Interaktionspartner

  1. results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS (zeige MAS1 Proteine)) and management in beef cattle breeding programs.

Sirtuin 6 (SIRT6) Protein Überblick

Protein Überblick

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit Sirtuin 6 Proteine (SIRT6)

  • sirtuin 6 (Sirt6)
  • sirtuin 6 (SIRT6)
  • sirtuin 6 S homeolog (sirt6.S)
  • sirtuin 6 (sirt6)
  • 2810449N18Rik Protein
  • AI043036 Protein
  • SIR2L6 Protein
  • zgc:86729 Protein

Bezeichner auf Proteinebene für Sirtuin 6 Proteine (SIRT6)

NAD-dependent deacetylase sirtuin-6 , NAD-dependent protein deacetylase sirtuin-6 , SIR2-like protein 6 , regulatory protein SIR2 homolog 6 , sir2-related protein type 6 , sirtuin type 6 , sirtuin (silent mating type information regulation 2 homolog) 6

GENE ID SPEZIES
50721 Mus musculus
51548 Homo sapiens
299638 Rattus norvegicus
428332 Gallus gallus
535416 Bos taurus
100126274 Sus scrofa
444018 Xenopus laevis
485045 Canis lupus familiaris
100734667 Cavia porcellus
415161 Danio rerio
737026 Pan troglodytes
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