Sirtuin 6 Proteine (SIRT6)

SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Zusätzlich bieten wir Ihnen Sirtuin 6 Antikörper (204) und Sirtuin 6 Kits (20) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SIRT6 50721 P59941
SIRT6 51548 Q8N6T7
SIRT6 299638  
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Top Sirtuin 6 Proteine auf antikoerper-online.de

Showing 10 out of 22 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
Escherichia coli (E. coli) Human His tag 100 μg 2 bis 3 Tage
$345.00
Details
Escherichia coli (E. coli) Ratte His tag 100 μg 15 bis 18 Tage
$720.00
Details
Wheat germ Human GST tag 2 μg 11 bis 12 Tage
$338.33
Details
Escherichia coli (E. coli) Human His tag   100 μg 15 bis 18 Tage
$512.00
Details
Escherichia coli (E. coli) Maus His tag 100 μg 15 bis 18 Tage
$576.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Escherichia coli (E. coli) Human His tag   10 μg 2 bis 3 Tage
$245.00
Details
Escherichia coli (E. coli) Human His tag   1 mg 2 bis 3 Tage
$6,867.69
Details

SIRT6 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,

Human , , ,
, ,
Rat (Rattus)

Am meisten referenzierte Sirtuin 6 Proteine

  1. Human SIRT6 Protein expressed in Wheat germ - ABIN1320053 : Palmer, Fullston, Mitchell, Setchell, Lane: SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity. in Reproduction, fertility, and development 2011 (PubMed)

Weitere Proteine zu Sirtuin 6 (SIRT6) Interaktionspartnern

Mouse (Murine) Sirtuin 6 (SIRT6) Interaktionspartner

  1. These findings establish that elevated p53 activity contributes significantly to accelerated aging in Sirt6-deficient mice. The study demonstrates that p53 is a substrate of SIRT6, and highlights the importance of SIRT6-p53 axis in the regulation of aging.

  2. these data suggest a novel role for SIRT6 in maintaining muscle mass by controlling expression of atrophic factors like Mstn and activin.

  3. Results show that SIRT6 controls osteogenic commitment through BMP signaling in a P300/CBP-associated factor (PCAF) dependent manner. These findings explored a novel cooperator for SIRT6, namely PCAF, and have discovered a new sirtuin-mediated pathway for the regulation of BMP signaling.

  4. Hepatocyte-specific Sirt6 deficiency impairs ketogenesis.

  5. SIRT6 deficiency results in decreased oxygen consumption rate and concomitantly lesser ATP production. Mechanistically, SIRT6 deficiency leads to increased FoxO1-mediated transcription of PDK4. Our findings establish a novel link between SIRT6 and cardiac metabolism, suggesting a protective role of SIRT6 in maintaining cardiac homeostasis.

  6. Molecularly, ATM phosphorylates SIRT6 deacetylase and thus prevents MDM2-mediated ubiquitination and proteasomal degradation.

  7. this study shows that SIRT6 protects against hepatic ischemia/reperfusion injury by inhibiting apoptosis and autophagy related cell death

  8. Overexpression of sirtuin 6 suppresses allergic airway inflammation through deacetylation of GATA3.

  9. Our data identify a role of myeloid Sirt6 in clinical and experimental RA and suggest that myeloid Sirt6 may be an intriguing therapeutic target.

  10. USP10 inhibits hepatic steatosis, insulin resistance, and inflammation through Sirt6.

  11. retinas from CNS conditionally deleted SIRT6 mice showed a resemblance to diabetic retinas exhibiting lower protein levels of BDNF factor and increased protein levels of VEGF

  12. Low SIRT6 expression is associated with Liver Tumorigenesis.

  13. the expression level of SIRT6 bi-directionally regulates contextual fear memory in mice.

  14. Sirt6 plays an important role in protecting intestinal epithelial cells against inflammatory injury in a mechanism associated with preserving Rspo1 levels in the cells.

  15. SIRT6 attenuates cisplatin-induced acute kidney injury by binding to the promoters of ERK1 and ERK2 and deacetylated histone 3 at Lys9 (H3K9) thereby inhibiting ERK1/2 expression.

  16. SIRT6 suppresses Txnip expression in beta cells via deacetylation of histone H3 and plays a critical role in maintaining beta cell function and viability

  17. therapeutic effect on periapical lesions through suppression of CCL2 synthesis

  18. Study provides evidence that sirtuin 6 (SIRT6) can protect the brain from cerebral cerebral ischemia/reperfusion injury by suppressing oxidative stress via nuclear factor (erythroid-derived 2)-like 2 activation. Thus, SIRT6 may serve as a potential therapeutic target for ischemic stroke.

  19. SIRT6 knockout cells resist apoptosis initiation but not progression.

  20. Sirt6 in pancreatic beta cells deacetylates FoxO1 and subsequently increases the expression of Pdx1 and Glut2 to maintain the glucose-sensing ability of pancreatic beta cells and systemic glucose tolerance.

Human Sirtuin 6 (SIRT6) Interaktionspartner

  1. our data suggest that inactivation of SIRT6 in leukemia cells leads to disruption of DNA-repair mechanisms, genomic instability and aggressive AML. This synthetic lethal approach, enhancing DNA damage while concomitantly blocking repair responses, provides the rationale for the clinical evaluation of SIRT6 modulators in the treatment of leukemia

  2. research findings demonstrate that SIRT6 serves as a tumor suppressor via regulation of the NF-kappaB pathway, which could offer an innovative strategy to treat adrenocortical carcinoma.

  3. Data showed that sirt6 attenuated cell senescence, and reduced apoptosis, by triggering autophagy that ultimately ameliorated IDD.

  4. This study showed that the SIRT6 plays a pathogenic and pro-inflammatory role in Parkinson's and that nicotine can provide neuroprotection by accelerating its degradation. Inhibition of SIRT6 may be a promising strategy to ameliorate Parkinson's and neurodegeneration.

  5. These results suggest that direct and reversible cysteine thiol 144 may play a functional role in SIRT6-dependent control over monocyte glycolysis, an important determinant of effector innate immune responses.

  6. SIRT6 gene expression is altered in adipose tissue from overweight and obese subjects compared to normal weight subjects.

  7. SIRT6 negatively regulates Dengue virus-induced inflammatory response via RIG-I-like receptor and Toll-like receptor 3 signaling pathways.

  8. Our data identify a role of myeloid Sirt6 in clinical and experimental RA and suggest that myeloid Sirt6 may be an intriguing therapeutic target.

  9. Overexpression of SIRT6 reduced acetylation of Ku70 and promoted interaction of Ku70 with the proapoptotic protein Bax.

  10. that the bimodal expression of SIRT6 at different melanoma stages plays a critical role in regulating melanoma growth through an autophagy-dependent manner, which indicates the potential of SIRT6 to be a biomarker and a therapeutic target in melanoma

  11. Findings provide mechanistic insights into the pro-metastatic activity of SIRT6 and highlight the role of the SIRT6/Snail/KLF4 axis in regulating EMT and invasion of NSCLC cells.

  12. Low SIRT6 expression is associated with Liver Tumorigenesis.

  13. Study findings present a novel mechanism that controls FOXO3 activation and revealed that SIRT6 is a pivotal regulatory factor in determining liver cancer chemosensitivity. SIRT6 interacts with FOXO3 and this interaction increases FOXO3 ubiquitination and decreases its stability.

  14. Low SIRT6 expression is associated with Hodgkin lymphoma.

  15. Sirt6 plays an important role in protecting intestinal epithelial cells against inflammatory injury in a mechanism associated with preserving Rspo1 levels in the cells.

  16. experiments revealed the mechanism for SIRT6 in facilitating tumorigenesis and metastasis of colon cancer cells, suggesting that SIRT6 might be a potential therapeutic target for treating colon cancer.

  17. SIRT6 inhibited proliferation, migration, and invasion of colon cancer cells by up-regulating PTEN expression and down-regulating AKT1 expression.

  18. SIRT6 may suppress cell proliferation, migration, and invasion via inhibition of the NOTCH3 signaling pathway in glioma

  19. Downregulation of SIRT6 expression may promote non-small cell lung cancer malignancy in the Chinese Han population.

  20. We provide a comprehensive overview of recent developments on the molecular signaling pathways controlled by SIRT1 and SIRT6, two post-translational modifiers proven to be valuable tools to dampen inflammation and oxidative stress at the cardiovascular level

Cow (Bovine) Sirtuin 6 (SIRT6) Interaktionspartner

  1. the underlying mechanism of methylation and transcription regulation of SIRT6 expression in bovine adipocytes

  2. results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS) and management in beef cattle breeding programs.

Sirtuin 6 (SIRT6) Protein Überblick

Protein Überblick

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit Sirtuin 6 Proteine (SIRT6)

  • sirtuin 6 (Sirt6)
  • sirtuin 6 (SIRT6)
  • sirtuin 6 S homeolog (sirt6.S)
  • sirtuin 6 (sirt6)
  • 2810449N18Rik Protein
  • AI043036 Protein
  • SIR2L6 Protein
  • zgc:86729 Protein

Bezeichner auf Proteinebene für Sirtuin 6 Proteine (SIRT6)

NAD-dependent deacetylase sirtuin-6 , NAD-dependent protein deacetylase sirtuin-6 , SIR2-like protein 6 , regulatory protein SIR2 homolog 6 , sir2-related protein type 6 , sirtuin type 6 , sirtuin (silent mating type information regulation 2 homolog) 6

GENE ID SPEZIES
50721 Mus musculus
51548 Homo sapiens
299638 Rattus norvegicus
428332 Gallus gallus
535416 Bos taurus
100126274 Sus scrofa
444018 Xenopus laevis
485045 Canis lupus familiaris
100734667 Cavia porcellus
415161 Danio rerio
737026 Pan troglodytes
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