anti-Sirtuin 6 (SIRT6) Antikörper

SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Zusätzlich bieten wir Ihnen Sirtuin 6 Proteine (20) und Sirtuin 6 Kits (18) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SIRT6 50721 P59941
SIRT6 51548 Q8N6T7
SIRT6 299638  
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Top anti-Sirtuin 6 Antikörper auf antikoerper-online.de

Showing 10 out of 219 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert ChIP, IP, WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (fro), IHC (p), IP, WB Detection of SIRT6 in MEF lysate using ABIN250952. Western Blot: SIRT6 Antibody [ABIN250952] - WB analysis of SIRT6 in NIH/3T3 cell lysate. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$444.19
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$229.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB Anti- SIRT6Picoband antibody, IHC(P) IHC(P): Mouse Cardiac Muscle Tissue Anti- SIRT6Picoband antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$280.00
Details
Human Kaninchen Unkonjugiert WB Western blot with Sirtuin 6 antibody: Lane 1: 60 µg Jurkat cell lysate Lane 2: 44 µg mouse muscle lysate Lane 3: 60 µg Rat kidney lysate Lane 4: 2 ng Recombinant Human Sirtuin 6 Lane 5: 10 ng Recombinant Human Sirtuin 6 Lane 6: 50 ng Recombinant Human Sirtuin 6 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$265.00
Details
Maus Kaninchen Unkonjugiert ICC, IHC, WB Figure. DAB staining on IHC-P; Samples: Mouse Liver Tissue. 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$360.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma Western blot analysis of SIRT6 Antibody (C-term) (ABIN390181) in mouse stomach tissue lysates (35 µg/lane). SIRT6 (arrow) was detected using the purified polyclonal antibody. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert WB SIRT6 antibody tested by Western blot. HeLa cells nuclear extract (25 μg) probed with SIRT6 antibody (1:1,000). 100 μL Anmelden zum Anzeigen 1 bis 2 Tage
$495.83
Details
Human Kaninchen Unkonjugiert ICC, IF, WB Detection of SIRT6 in HeLa whole cell lysate using ABIN250956. Immunocytochemistry/Immunofluorescence: SIRT6 Antibody [ABIN250956] - SIRT6 antibody was tested in Hela cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$444.19
Details
Human Kaninchen Unkonjugiert IHC (p), WB SIRT6 Antibody (C-term) (ABIN657945) western blot analysis in K562 cell line lysates (35 µg/lane). This demonstrates the SIRT6 antibody detected the SIRT6 protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details

SIRT6 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-Sirtuin 6 Antikörper

  1. Human Polyclonal SIRT6 Primary Antibody für ICC, IF - ABIN250952 : Sundaresan, Vasudevan, Zhong, Kim, Samant, Parekh, Pillai, Ravindra, Gupta, Jeevanandam, Cunningham, Deng, Lombard, Mostoslavsky, Gupta: The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. in Nature medicine 2012 (PubMed)
    Show all 11 Pubmed References

  2. Human Polyclonal SIRT6 Primary Antibody für IHC - ABIN967033 : Frye: Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. in Biochemical and biophysical research communications 2000 (PubMed)
    Show all 5 Pubmed References

  3. Human Polyclonal SIRT6 Primary Antibody für IHC - ABIN967032 : Dephoure, Zhou, Villén, Beausoleil, Bakalarski, Elledge, Gygi: A quantitative atlas of mitotic phosphorylation. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 5 Pubmed References

  4. Human Monoclonal SIRT6 Primary Antibody für ELISA - ABIN526804 : Grimley, Polyakova, Vamathevan, McKenary, Hayes, Patel, Smith, Bridges, Fosberry, Bhardwaja, Mouzon, Chung, Barrett, Richmond, Modha, Solari: Over expression of wild type or a catalytically dead mutant of Sirtuin 6 does not influence NF?B responses. in PLoS ONE 2012 (PubMed)
    Show all 2 Pubmed References

  5. Cow (Bovine) Polyclonal SIRT6 Primary Antibody für ChIP, IP - ABIN2779624 : Wajapeyee, Malonia, Palakurthy, Green: Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. in Genes & development 2013 (PubMed)
    Show all 2 Pubmed References

  6. Human Polyclonal SIRT6 Primary Antibody für IHC (p), WB - ABIN390181 : Wu, Liu, Fu, Liu, Zhou: Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients. in Annals of clinical and laboratory science 2014 (PubMed)
    Show all 2 Pubmed References

  7. Human Polyclonal SIRT6 Primary Antibody für IF (p), IHC (p) - ABIN712481 : Thirumurthi, Shen, Xia, LaBaff, Wei, Li, Chang, Chen, Lin, Yu, Hung: MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer. in Science signaling 2014 (PubMed)

  8. Human Polyclonal SIRT6 Primary Antibody für ICC, IF - ABIN250956 : Benavente, Schnell, Jacobson: Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin. in PLoS ONE 2012 (PubMed)

  9. Human Polyclonal SIRT6 Primary Antibody für WB - ABIN2668661 : Rajendran, Kidane, Yu, Dashwood, Bisson, Löhr, Ho, Williams, Dashwood: HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. in Epigenetics 2013 (PubMed)

Weitere Antikörper gegen Sirtuin 6 Interaktionspartner

Mouse (Murine) Sirtuin 6 (SIRT6) Interaktionspartner

  1. SIRT6 interacts with and promotes phospho-ATF2 (zeige ATF2 Antikörper) binding to the PGC-1alpha gene promoter to activate its expression. The present study reveals a critical role for SIRT6 in regulating thermogenesis of fat.

  2. p53 (zeige TP53 Antikörper)-dependent SIRT6 expression protects cells from Abeta42-induced DNA damage.

  3. Moreover, the authors showed that Sirt6, induced by RANKL (zeige TNFSF11 Antikörper)-dependent NFATc1 (zeige NFATC1 Antikörper) expression, forms a complex with B lymphocyte-induced maturation protein-1 (Blimp1 (zeige PRDM1 Antikörper)) to negatively regulate expression of anti-osteoclastogenic gene such as Mafb (zeige MAFB Antikörper).

  4. Collectively, our findings uncover the autophagy modulated by SIRT6 may be a proinflammatory mechanism for amyloid-beta induced RPE (zeige RPE Antikörper) dysfunction.

  5. Sirt6 inhibits Notch1 (zeige NOTCH1 Antikörper) and Notch4 (zeige NOTCH4 Antikörper) transcription by deacetylating histone H3K9.

  6. Sirt6 is downregulated in induced pluripotent stem cells from old mice.

  7. post-translational modification facilitates the mobilization of SIRT6 to DNA damage sites and is required for efficient recruitment of poly (ADP-ribose) polymerase 1 (PARP1 (zeige PARP1 Antikörper)) to DNA break sites and for efficient repair of double-strand break.

  8. SIRT6 and its downstream signaling could be targeted in Alzheimer's disease and age-related neurodegeneration.

  9. These findings reveal a crucial role of SIRT6 in adipogenesis and provide potential therapeutic targets for obesity.

  10. Global and endothelium-specific SIRT6 knockout mice exhibited impaired endothelium-dependent vasorelaxation. Moreover, SIRT6(+/-) haploinsufficient mice fed a high-fat diet (HFD) also displayed impaired endothelium-dependent vasorelaxation. Importantly, SIRT6(+/-); ApoE(-/-) mice after HFD feeding had exacerbated atherosclerotic lesion development, concurrent with increased expression of proinflammatory cytokine VCAM-1.

Human Sirtuin 6 (SIRT6) Interaktionspartner

  1. SIRT6 interacts with and promotes phospho-ATF2 (zeige ATF2 Antikörper) binding to the PGC-1alpha gene promoter to activate its expression. The present study reveals a critical role for SIRT6 in regulating thermogenesis of fat.

  2. nf-kappab (zeige NFKB1 Antikörper) was was increases duto to SIRT6 silencing in the absence of UV-B

  3. p53 (zeige TP53 Antikörper)-dependent SIRT6 expression protects cells from Abeta42-induced DNA damage.

  4. Strong correlation has been proved between the expression levels of HDAC4 (zeige HDAC4 Antikörper) and SIRT6.

  5. SirT6 promotes cysteine ubiquitination in the PRE-SET domain of Suv39h1 (zeige SUV39H1 Antikörper).

  6. this study not only suggests potential roles of SIRT6 in regulating apoptosis and stress resistance via direct deacetylation of p53 (zeige TP53 Antikörper), but also provides lead compound for the development of potent and selective SIRT6 inhibitors.

  7. in vitro and in vivo studies showed that gene silencing of SIRT6 suppressed cell proliferation and promoted cellular apoptosis by activating the Bax (zeige BAX Antikörper)-dependent apoptotic signal pathway in Hepatocellular Carcinoma cells. Furthermore, SIRT6 knockdown could increase liver cancer cell sensitivity to chemotherapy drug doxorubicin. SIRT6 is an important protumorigenic factor in liver carcinogenesis.

  8. SIRT6 is upregulated in non-small cell lung cancer; it may have a functional role in promoting migration and invasion through ERK1/2/MMP9 (zeige MMP9 Antikörper) signaling

  9. Sirt6 inhibits Notch1 (zeige NOTCH1 Antikörper) and Notch4 (zeige NOTCH4 Antikörper) transcription by deacetylating histone H3K9.

  10. These data provide the first evidence of the Egt ability to interfere with endothelial senescence linked to hyperglycaemia through the regulation of SIRT1 (zeige SIRT1 Antikörper) and SIRT6 signaling, thus further strengthening the already assessed role of these two histone deacetylases in type 2 diabetes.

Cow (Bovine) Sirtuin 6 (SIRT6) Interaktionspartner

  1. results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS (zeige MAS1 Antikörper)) and management in beef cattle breeding programs.

Sirtuin 6 (SIRT6) Antigen-Profil

Protein Überblick

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit anti-Sirtuin 6 (SIRT6) Antikörper

  • sirtuin 6 (Sirt6) Antikörper
  • sirtuin 6 (SIRT6) Antikörper
  • sirtuin 6 S homeolog (sirt6.S) Antikörper
  • sirtuin 6 (sirt6) Antikörper
  • 2810449N18Rik Antikörper
  • AI043036 Antikörper
  • SIR2L6 Antikörper
  • zgc:86729 Antikörper

Bezeichner auf Proteinebene für anti-Sirtuin 6 (SIRT6) Antikörper

NAD-dependent deacetylase sirtuin-6 , NAD-dependent protein deacetylase sirtuin-6 , SIR2-like protein 6 , regulatory protein SIR2 homolog 6 , sir2-related protein type 6 , sirtuin type 6 , sirtuin (silent mating type information regulation 2 homolog) 6

GENE ID SPEZIES
50721 Mus musculus
51548 Homo sapiens
299638 Rattus norvegicus
428332 Gallus gallus
535416 Bos taurus
100126274 Sus scrofa
444018 Xenopus laevis
485045 Canis lupus familiaris
100734667 Cavia porcellus
415161 Danio rerio
737026 Pan troglodytes
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