Sirtuin 5 Proteine (SIRT5)

SIRT5 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Zusätzlich bieten wir Ihnen Sirtuin 5 Antikörper (185) und Sirtuin 5 Kits (20) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SIRT5 23408 Q9NXA8
SIRT5 68346 Q8K2C6
SIRT5 306840 Q68FX9
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Showing 10 out of 21 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
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Escherichia coli (E. coli) Ratte His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$704.00
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Escherichia coli (E. coli) Human GST tag 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$295.00
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$888.80
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Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 13 bis 16 Tage
$400.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Escherichia coli (E. coli) Maus His tag   100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$560.00
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Hefe Xenopus tropicalis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,715.17
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Hefe Huhn His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,715.17
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SIRT5 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, , ,
Mouse (Murine) ,

Rat (Rattus) ,

Weitere Proteine zu Sirtuin 5 (SIRT5) Interaktionspartnern

Human Sirtuin 5 (SIRT5) Interaktionspartner

  1. Our study reveals a novel role of SIRT5 in inhibiting peroxisome-induced oxidative stress, in liver protection, and in suppressing hepatocellular carcinoma development.

  2. Hepatic overexpression of SIRT5 ameliorated the metabolic abnormalities of ob/ob mice, probably through demalonylating and desuccinylating proteins in the main metabolic pathways. SIRT5 and related acylation might be potential targets for metabolic disorders.

  3. SIRT5 plays pivotal roles in cardiac physiology and stress responses and is involved in the regulation of numerous aspects of myocardial energy metabolism. SIRT5 is implicated in neoplasia, as both a tumor promoter and suppressor in a context-specific manner, and may serve a protective function in the setting of neurodegenerative disorders.

  4. In human beings, SIRT5 gene encodes for four SIRT5 protein isoforms, namely SIRT5iso1, SIRT5iso2, SIRT5iso3, and SIRT5iso4. SIRT5(iso1-3) were mitochondria-localized, while SIRT5(iso4) localized mainly in cytoplasm. SIRT5(iso2-4) had little deacylase activity comparing with SIRT5(iso1).

  5. miR-299-3p suppresses migration, invasion and proliferation of Hepatocellular carcinoma cells via directly targeting SIRT5

  6. High SIRT5 expression is associated with Cancer Cell Proliferation.

  7. The DNA variants and SNPs identified in acute Myocardial infection (AMI) patients may change SIRT5 level by affecting activity of SIRT5 gene promoter, contributing to the AMI development as a risk factor.

  8. In this study, we summarize biological functions of SIRT5 reported in normal tissues and in cancer and discuss potential mechanisms whereby SIRT5 may impact tumorigenesis, particularly focusing on its reported roles in metabolic reprogramming. Finally, we review current efforts to target SIRT5 pharmacologically

  9. The roles of the CDK2/SIRT5 axis in gastric cancer.

  10. SIRT5 gene has an important regulatory role in liver carcinogenesis, and may function as a novel potential therapeutic target for HCC.

  11. This study showed that SIRT5 supports the anaplerotic entry of glutamine into the TCA cycle in malignant phenotypes of CRC via activating GLUD1.

  12. Results show that SIRT5 binds to, desuccinylates and inhibits PKM2 activity. Increased levels of reactive oxygen species (ROS) decreases succinylation and activity of PKM2 by increasing its binding to SIRT5. Moreover, inhibition of SIRT5 suppresses tumor cell proliferation through desuccinylation of PKM2 K498.

  13. The function of the three mitochondrial sirtuins (SIRT3, SIRT4, SIRT5) and their role in disease are reviewed.

  14. Our study uncovers a SIRT5-dependent mechanism that regulates cellular NADPH homeostasis and redox potential by promoting IDH2 desuccinylation and G6PD deglutarylation.

  15. Results demonstrated presence of endogenous SIRT5 in mitochondria of cultured SH-EP cells, identified down-regulation of cellular oxidative stress by SIRT5 as one of the possible mechanisms mediating the anti-apoptotic effect of SIRT5 in SH-EP cells.

  16. Data (including data from studies using knockout mice) suggest that SIRT5 is targeted to protein complexes on the inner mitochondrial membrane via affinity for cardiolipin to promote respiratory chain function, particularly Complex I and Complex II; SIRT5 expression is observed in inner mitochondrial membrane of periportal hepatocytes.

  17. a side chain-to-side chain cyclic pentapeptide harboring a central N(epsilon)-carboxyethyl-thiocarbamoyl-lysine residue behaved as a strong and selective (versus human SIRT1/2/3/6) inhibitor against human SIRT5-catalyzed deacylation reaction.

  18. Data indicate that compared to non-neoplastic endometria (NNE), endometrial cancer (EC) showed SIRT7 mRNA overexpression, whereas SIRT1, SIRT2, SIRT4 and SIRT5 were underexpressed, and no significant differences were observed for SIRT3 and SIRT6.

  19. Use of a pan-sirtuin inhibitor and shRNA-mediated protein knockdown led us to uncover a role for the NAD(+)-dependent family of sirtuins, and in particular for SIRT2 and SIRT5, in the regulation of the necroptotic cell death program

  20. mutual cooperation between Y102 and R105 residues in promoting the desuccinylation versus deacetylation reaction in SIRT5.

Mouse (Murine) Sirtuin 5 (SIRT5) Interaktionspartner

  1. Our study reveals a novel role of SIRT5 in inhibiting peroxisome-induced oxidative stress, in liver protection, and in suppressing hepatocellular carcinoma development.

  2. It confirms the role of Sirt5 as an important demalonylase and desuccinylase enzyme in vivo, but questions the relevance of physiological changes in mitochondrial protein acylation levels in the regulation of cellular metabolism.

  3. Loss of SIRT5 expression is associated with cardiac hypertrophy.

  4. Data indicate that sirtuin 5 (SIRT5) is an important mitochondrial enzyme for protection against metabolic and ischemic stress following protein kinase C epsilon (PKCepsilon) activation in the brain.

  5. findings reveal a key role for SIRT5 in maintaining cardiac oxidative metabolism under pressure overload to ensure survival

  6. Deletion of Sirt5 in starved mouse embryonic fibroblasts increased levels of mitochondrial dynamics leading to mitochondrial accumulation of the pro-fission Drp1 and to mitochondrial fragmentation.

  7. Our study uncovers a SIRT5-dependent mechanism that regulates cellular NADPH homeostasis and redox potential by promoting IDH2 desuccinylation and G6PD deglutarylation.

  8. Data (including data from studies using knockout mice) suggest that SIRT5 is targeted to protein complexes on the inner mitochondrial membrane via affinity for cardiolipin to promote respiratory chain function, particularly Complex I and Complex II; SIRT5 expression is observed in inner mitochondrial membrane of periportal hepatocytes.

  9. Data show that peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) overexpression significantly increased the expression of sirtuin 3 (SIRT3) and sirtuin 5 (SIRT5).

  10. In the cochlea, the expression of SIRT1, 3, and 5 (both mRNA and protein) was decreased in the old mice

  11. These findings establish that regulating heart metabolism and function is a major physiological function of lysine succinylation and SIRT5.

  12. Myocardial ischemic reperfusion injury in Sirt5-/- heart is restored to wild-type levels by pretreatment with dimethyl malonate, a competitive inhibitor of succinate dehydrogenase (SDH), implicating alteration in SDH activity as causative of the injury.

  13. SIRT5 has a role in cellular metabolism with a multiple enzymatic activities

  14. SIRT3 and SIRT5 regulate the enzyme activity and cardiolipin binding of very long-chain acyl-CoA dehydrogenase

  15. Pathway analysis identified glycolysis as the top SIRT5-regulated pathway. Importantly, glycolytic flux was diminished in primary hepatocytes from Sirt5(-/-) compared to WT mice.

  16. Data indicated that SIRT5 ameliorates MPTP-induced nigrostriatal dopaminergic degeneration via preserving mitochondrial antioxidant capacity.

  17. Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.

  18. Loss of SIRT5 leads to accumulation of medium- and long-chain acylcarnitines and decreased beta-hydroxybutyrate production in vivo.

  19. Sirt5 is likely to be dispensable for the metabolic homeostasis under the basal conditions.

  20. We have isolated and characterized the murine sirt5 genomic sequence, which spans a region of 24,449 bp and which has one single genomic locus.

Cow (Bovine) Sirtuin 5 (SIRT5) Interaktionspartner

  1. We further analyzed the regulatory elements in the SIRT5 promoter region of -239/-18bp using the Genomatix suite. Two motifs as TF binding sites for E2F4 and KLF6, which contained two methylation sites, were identified in this region (Fig. 1B). Additionally, we found that the methylation level of CpG in the SIRT5 promoter in differentiation adipocytes was enhanced compared to that present in undifferentiation adipocytes

  2. Association analysis of individual SIRT5 SNPs and haplotype combinations reveal that the 4 loci are significantly associated with some body measurement and ultrasound traits in Qinchuan cattle.

Sirtuin 5 (SIRT5) Protein Überblick

Protein Überblick

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit Sirtuin 5 Proteine (SIRT5)

  • sirtuin 5 (SIRT5)
  • sirtuin 5 (Sirt5)
  • sirtuin 5 (sirt5)
  • sirtuin 5 L homeolog (sirt5.L)
  • sirtuin 5 (CC1G_00083)
  • 0610012J09Rik Protein
  • 1500032M05Rik Protein
  • AV001953 Protein
  • sir2l5 Protein
  • SIRT5 Protein
  • sirt5-a Protein
  • zgc:92288 Protein

Bezeichner auf Proteinebene für Sirtuin 5 Proteine (SIRT5)

NAD-dependent deacetylase sirtuin-5 , NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial , NAD-dependent protein deacylase sirtuin-5, mitochondrial , SIR2-like protein 5 , regulatory protein SIR2 homolog 5 , silent mating type information regulation 2, S.cerevisiae, homolog 5 , sir2-like 5 , sirtuin type 5 , Regulatory protein SIR2 homolog 5 , NAD-dependent lysine demalonylase and desuccinylase sirtuin-5A, mitochondrial , NAD-dependent protein deacylase sirtuin-5A, mitochondrial , regulatory protein SIR2 homolog 5-a , sirtuin (silent mating type information regulation 2 homolog) 5 , sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) , sirtuin 5 , nad-dependent deacetylase sirtuin-5

GENE ID SPEZIES
23408 Homo sapiens
68346 Mus musculus
306840 Rattus norvegicus
420834 Gallus gallus
436878 Danio rerio
478726 Canis lupus familiaris
496346 Xenopus laevis
507347 Bos taurus
700855 Macaca mulatta
747069 Pan troglodytes
6013501 Coprinopsis cinerea okayama7130
100125966 Sus scrofa
100170199 Xenopus (Silurana) tropicalis
100173543 Pongo abelii
100528250 Ictalurus punctatus
100718110 Cavia porcellus
100339154 Oryctolagus cuniculus
100860989 Capra hircus
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