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SIRT2 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein.
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Sirt2 has an role in the regulation of mitochondrial energy metabolism.
SRT2 is important in fine-tuning mitochondrial energy metabolism.
AtSRT2 is a deacetylase that negatively regulates the plant basal defense and PR1 expression.
SIRT2 participates in the activation of fibroblasts and tubulointerstitial fibrosis, which is mediated via regulation of the MDM2 (zeige MDM2 ELISA Kits) pathway, and the downregulation of SIRT2.
Findings suggested that the DNA sequence variants may increase SIRT2 gene promoter activity and SIRT2 levels, contributing to T2D development as a risk factor.
Chemical inhibitors against SIRT2 suppress G6PD activity, leading to reduced cell proliferation of leukaemia cells, but not normal hematopoietic stem and progenitor cells. Importantly, SIRT2 is overexpressed in clinical acute myeloid leukaemia samples, while K403 acetylation is downregulated and G6PD catalytic activity is increased comparing to that of normal control.
SIRT2 may have a role in unfavorable prognosis of acute myeloid leukemia (zeige BCL11A ELISA Kits)
Data suggest that inhibition of sirtuin 1 and sirtuin 2 in hepatocellular carcinoma cells (a) impairs cell survival and cell migration and (b) down-regulates expression of P-glycoprotein and MRP3 (ATP binding cassette subfamily C member 3).
SIRT2 inhibition may improve microtubule assembly thus representing a valid approach as disease-modifying therapy for Alzheimer's disease.
Data show that single nucleotide polymorphism rs2015C in sirtuin 2 protein (SIRT2) gene 3'-UTR (zeige UTS2R ELISA Kits) was significantly associated with increased risk of colorectal cancer (CRC (zeige CALR ELISA Kits)).
Authors show that SIRT2 is downregulated in insulin (zeige INS ELISA Kits)-resistant hepatocytes and livers, and this was accompanied by increased generation of reactive oxygen species, activation of stress-sensitive ERK1/2 (zeige MAPK1/3 ELISA Kits) kinase, and mitochondrial dysfunction.
Those findings highlight the potential role of SIRT2 in HBV and HBV-mediated HCC by interaction with HBx.
The SIRT2 functions as a mitochondrial sirtuin (zeige SIRT1 ELISA Kits), as well as a regulator of autophagy/mitophagy to maintain mitochondrial biology, thus facilitating cell survival.
The results indicate that the variations in the class I sirtuin (zeige SIRT1 ELISA Kits) genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.
An association analysis showed that the two loci of SIRT2 were significantly correlated with some body size traits and the H2H2 (-CT-CT (zeige CALCA ELISA Kits)-) diplotypes performed better than other combinations.
Data suggest that the silent information regulator 2 (SIRT2) gene may be a candidate gene for marker-assisted selection in the development of breeding programs for Qinchuan cattle.
CDK5 (zeige CDK5 ELISA Kits)-mediated phosphorylation of Sirt2 has a role in to depressive-like behavior induced by social defeat stress
These results confirm that SIRT2 inhibition is able to reverse anhedonia in different animal models and highlight the need to further investigate the role of SIRT2 inhibitors as new antidepressant agents.
SIRT2 knockout mice show marked up-regulation in AMPAR acetylation and protein accumulation, aberrant synaptic plasticity and impaired memory.
Given the significance of KRAS activity as a driver in tumorigenesis, identification of K147 acetylation as a novel post-translational modification directed by SIRT2 in vivo may provide a better understanding of the mechanistic link regarding the crosstalk between non-genetic and genetic factors in KRAS driven tumors.
SIRT2 modulates microvascular inflammation in sepsis and affects survival
This study showed that Sirt2-dependent GKRP (zeige GCKR ELISA Kits) deacetylation improves impaired HGU and suggest that it may be a therapeutic target for type 2 diabetes.
AMPK (zeige PRKAA1 ELISA Kits) and Sirt2 control compensatory glucose uptake in metabolically arrested mitochondria.
SIRT2 promotes AMPK (zeige PRKAA1 ELISA Kits) activation by deacetylating the kinase LKB1 (zeige STK11 ELISA Kits). Loss of SIRT2 reduces AMPK (zeige PRKAA1 ELISA Kits) activation, promotes aging-related and Ang II (zeige AGT ELISA Kits)-induced cardiac hypertrophy, and blunts metformin-mediated cardioprotective effects.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.
, sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)
, sirtuin 2
, NAD-dependent deacetylase SIRT2
, NAD-dependent deacetylase sirtuin-2
, histone NADC
, silent information regulator 2
, nicotinamide adenine dinucleotide-dependent histone deacetylase
, NAD-dependent deacetylase sirtuin 2 homolog
, NAD-dependent protein deacetylase sirtuin-2
, SIR2-like protein 2
, regulatory protein SIR2 homolog 2
, sir2-related protein type 2
, sirtuin type 2
, sirtuin-like protein 2
, silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2
, 5E5 antigen