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SIRT2 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Zusätzlich bieten wir Ihnen Sirtuin 2 Antikörper (129) und Sirtuin 2 Proteine (19) und viele weitere Produktgruppen zu diesem Protein an.
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Sirt2 has an role in the regulation of mitochondrial energy metabolism.
SRT2 is important in fine-tuning mitochondrial energy metabolism.
AtSRT2 is a deacetylase that negatively regulates the plant basal defense and PR1 expression.
SIRT2 inhibition may improve microtubule assembly thus representing a valid approach as disease-modifying therapy for Alzheimer's disease.
Data show that single nucleotide polymorphism rs2015C in sirtuin 2 protein (SIRT2) gene 3'-UTR (zeige UTS2R ELISA Kits) was significantly associated with increased risk of colorectal cancer (CRC (zeige CALR ELISA Kits)).
Authors show that SIRT2 is downregulated in insulin (zeige INS ELISA Kits)-resistant hepatocytes and livers, and this was accompanied by increased generation of reactive oxygen species, activation of stress-sensitive ERK1/2 (zeige MAPK1/3 ELISA Kits) kinase, and mitochondrial dysfunction.
Those findings highlight the potential role of SIRT2 in HBV and HBV-mediated HCC by interaction with HBx.
The SIRT2 functions as a mitochondrial sirtuin (zeige SIRT1 ELISA Kits), as well as a regulator of autophagy/mitophagy to maintain mitochondrial biology, thus facilitating cell survival.
increased expression of SRF that was observed in the aged heart may affect SIRT2 gene expression and contribute to altered metabolic status in senescence
SIRT2 and RIPK1 (zeige RIPK1 ELISA Kits) were localized to the syncytiotrophoblast, villous leukocytes and vasculature in all preterm placentas. A significant reduction in SIRT2 protein expression in both preeclampsia and fetal growth restricted placentas was identified. Immunofluorescence identified both SIRT2 and RIPK1 (zeige RIPK1 ELISA Kits) in the cytotrophoblast cytoplasm.
mutations in sirtuin2 increase the stability of the conserved catalytic sirtuin (zeige SIRT1 ELISA Kits) domain, thereby increasing the catalytic efficiency of the mutant enzymes.
targeting SIRT2 may be a rational strategy for diminishing Slug abundance and its associated malignant traits in basal-like breast cancer.
BEX4 overexpression causes an imbalance between TUB acetylation and deacetylation by SIRT2 inhibition and induces oncogenic aneuploidy transformation.
The results indicate that the variations in the class I sirtuin (zeige SIRT1 ELISA Kits) genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.
An association analysis showed that the two loci of SIRT2 were significantly correlated with some body size traits and the H2H2 (-CT-CT (zeige CALCA ELISA Kits)-) diplotypes performed better than other combinations.
Data suggest that the silent information regulator 2 (SIRT2) gene may be a candidate gene for marker-assisted selection in the development of breeding programs for Qinchuan cattle.
Given the significance of KRAS activity as a driver in tumorigenesis, identification of K147 acetylation as a novel post-translational modification directed by SIRT2 in vivo may provide a better understanding of the mechanistic link regarding the crosstalk between non-genetic and genetic factors in KRAS driven tumors.
SIRT2 modulates microvascular inflammation in sepsis and affects survival
This study showed that Sirt2-dependent GKRP (zeige GCKR ELISA Kits) deacetylation improves impaired HGU and suggest that it may be a therapeutic target for type 2 diabetes.
AMPK (zeige PRKAA1 ELISA Kits) and Sirt2 control compensatory glucose uptake in metabolically arrested mitochondria.
SIRT2 promotes AMPK (zeige PRKAA1 ELISA Kits) activation by deacetylating the kinase LKB1 (zeige STK11 ELISA Kits). Loss of SIRT2 reduces AMPK (zeige PRKAA1 ELISA Kits) activation, promotes aging-related and Ang II (zeige AGT ELISA Kits)-induced cardiac hypertrophy, and blunts metformin-mediated cardioprotective effects.
found a decreased ratio of dopaminergic neurons in primary midbrain cultures treated with the SIRT2 inhibitor AK-7
mitochondrial dysfunction triggers LKB1 (zeige STK11 ELISA Kits)-mediated AMPK (zeige PRKAA1 ELISA Kits) activation, which stimulates Sirt2 phosphorylation, leading to activation of mTOR (zeige FRAP1 ELISA Kits)-RAPTOR (zeige RPTOR ELISA Kits) and Glut1 (zeige SLC2A1 ELISA Kits)-mediated glucose uptake.
SIRT-2 regulates microvascular inflammation in obese mice with sepsis.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.
, sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)
, sirtuin 2
, NAD-dependent deacetylase SIRT2
, NAD-dependent deacetylase sirtuin-2
, histone NADC
, silent information regulator 2
, nicotinamide adenine dinucleotide-dependent histone deacetylase
, NAD-dependent deacetylase sirtuin 2 homolog
, NAD-dependent protein deacetylase sirtuin-2
, SIR2-like protein 2
, regulatory protein SIR2 homolog 2
, sir2-related protein type 2
, sirtuin type 2
, sirtuin-like protein 2
, silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2
, 5E5 antigen