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SILV encodes a melanocyte-specific type I transmembrane glycoprotein.
Showing 2 out of 2 products:
Melanosome number, shape and movement in the retinal pigment epitheliummelanosome number, shape and movement in the zebrafish retinal pigment epithelium by OA1 (zeige GPR143 Antikörper) and PMEL (zeige PMEL Antikörper) are regulated by OA1 (zeige GPR143 Antikörper), pmela and pmelb.
This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.
silver homolog (mouse)
, melanocyte protein Pmel 17
, melanosome matrix protein