anti-Signal Peptide Peptidase-Like 2B (SPPL2B) Antikörper

SPPL2B encodes a member of the GXGD family of aspartic proteases. Zusätzlich bieten wir Ihnen SPPL2B Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SPPL2B 56928 Q8TCT7
SPPL2B 73218 Q3TD49
SPPL2B 362828 Q5PQL3
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Top anti-SPPL2B Antikörper auf antikoerper-online.de

Showing 9 out of 9 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC (p), WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Kaninchen Unkonjugiert IHC, IHC (p), WB Immunohistochemistry-Paraffin: Signal peptide peptidase-like 2B Antibody [NBP1-59510] - Human kidney Tissue, antibody concentration 4-8ug/ml. Cells with positive label: renal corpuscle cells (indicated with arrows) 400X magnification. Western Blot: Signal peptide peptidase-like 2B Antibody [NBP1-59510] - Jurkat cell lysate, concentration 1 ug/ml. 100 μL Anmelden zum Anzeigen 8 bis 11 Tage
$485.88
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Human Kaninchen Unkonjugiert IHC, ELISA, WB 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$446.88
Details
Human Kaninchen Unkonjugiert IHC, WB SPPL2B antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain Epithelial cells of renal tubule (arrows) in Human Kidney. Magnification is at 400X SPPL2B antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml. Magnification is at 400X 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$473.93
Details
Human Kaninchen Unkonjugiert ICC, IF, WB Western Blot: Signal peptide peptidase-like 2B Antibody  - Western blot analysis in human cell line RT-4 and human cell line U-251 MG. Immunocytochemistry/Immunofluorescence: Signal peptide peptidase-like 2B Antibody  - Staining of human cell line SiHa shows localization to nucleoplasm, plasma membrane & centrosome. 100 μL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
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Human Kaninchen Unkonjugiert WB   50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB   100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$306.90
Details

SPPL2B Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität
Human


Mouse (Murine)


Rat (Rattus)


Am meisten referenzierte anti-SPPL2B Antikörper

  1. Cow (Bovine) Polyclonal SPPL2B Primary Antibody für IHC, WB - ABIN2782090 : Del Campo, Hoozemans, Dekkers, Rozemuller, Korth, Müller-Schiffmann, Scheltens, Blankenstein, Jimenez, Veerhuis, Teunissen: BRI2-BRICHOS is increased in human amyloid plaques in early stages of Alzheimer's disease. in Neurobiology of aging 2014 (PubMed)

Weitere Antikörper gegen SPPL2B Interaktionspartner

Zebrafish Signal Peptide Peptidase-Like 2B (SPPL2B) Interaktionspartner

  1. SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP (zeige HM13 Antikörper) and SPPL3 (zeige SPPL3 Antikörper) are restricted to the ER.

Human Signal Peptide Peptidase-Like 2B (SPPL2B) Interaktionspartner

  1. TfR1 (zeige TFRC Antikörper) N-terminal fragment is a substrate for intramembrane proteolysis by SPPL2b.

  2. The alpha-helical content of the transmembrane domain of the British dementia protein-2 (Bri2 (zeige ITM2B Antikörper)) determines its processing by signal peptide peptidase-like 2b (SPPL2b).

  3. SPP (zeige SPEB Antikörper), SPPL2a (zeige SPPL2A Antikörper), -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis

  4. SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP (zeige SPEB Antikörper) and SPPL3 (zeige SPPL3 Antikörper) are restricted to the ER.

  5. Results demonstrate that SPPL2b utilizes multiple intramembrane cleavages to liberate the intracellular domain of tumor necrosis factor alpha (zeige TNF Antikörper) into the cytosol.

  6. SPPL2a (zeige SPPL2A Antikörper) and SPPL2b mediate the intramembrane cleavage, whereas neither SPP (zeige SPEB Antikörper) nor SPPL3 (zeige SPPL3 Antikörper) is capable of processing the Bri2 (zeige ITM2B Antikörper) N-terminal fragment.

  7. Alzheimer disease-like mutant SPPL2b slowed intramembrane proteolysis of tumor necrosis factor alpha (zeige TNF Antikörper) and caused a relative increase of longer intracellular cleavage products.

Mouse (Murine) Signal Peptide Peptidase-Like 2B (SPPL2B) Interaktionspartner

  1. in vivo SPPL2a (zeige SPPL2A Antikörper), but not SPPL2b, exhibit a physiologically relevant contribution to CD74 (zeige CD74 Antikörper) proteolysis in B and dendritic cells

SPPL2B Antigen-Profil

Protein Überblick

This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit SPPL2B

  • signal peptide peptidase-like 2 (sppl2) Antikörper
  • signal peptide peptidase like 2B (sppl2b) Antikörper
  • signal peptide peptidase like 2B S homeolog (sppl2b.S) Antikörper
  • signal peptide peptidase like 2B (SPPL2B) Antikörper
  • signal peptide peptidase like 2B (Sppl2b) Antikörper
  • signal peptide peptidase-like 2B (Sppl2b) Antikörper
  • 3110056O03Rik Antikörper
  • AW550292 Antikörper
  • IMP-4 Antikörper
  • IMP4 Antikörper
  • MGC147524 Antikörper
  • PSH4 Antikörper
  • PSL1 Antikörper
  • RGD1308556 Antikörper
  • SPPL2B Antikörper
  • wu:fc16e01 Antikörper
  • wu:fc85d12 Antikörper
  • zgc:136525 Antikörper

Bezeichner auf Proteinebene für SPPL2B

signal peptide peptidase-like 2B , signal peptide peptidase-like protein 2 , SPP-like 2B , protein SPP-like 2B , protein SPPL2b , intramembrane protease 4 , presenilin homologous protein 4 , presenilin-like protein 1

GENE ID SPEZIES
325540 Danio rerio
780336 Xenopus (Silurana) tropicalis
379574 Xenopus laevis
420056 Gallus gallus
56928 Homo sapiens
73218 Mus musculus
504285 Bos taurus
362828 Rattus norvegicus
Ausgewählte Anbieter für anti-SPPL2B (SPPL2B) Antikörper
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