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This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. Zusätzlich bieten wir Ihnen Sex Determining Region Y Proteine (44) und Sex Determining Region Y Kits (17) und viele weitere Produktgruppen zu diesem Protein an.
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Human Monoclonal SRY Primary Antibody für FACS, IHC - ABIN1098106
Peng, Ivanov, Oh, Lau, Rauscher: Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery. in The Journal of biological chemistry 2009
Show all 2 Pubmed References
Activation of SRY and its downstream Sox9 (zeige SOX9 Antikörper) and PDGFRalpha pathways are commonly involved in male hepatocarcinogenesis, which provides novel insights into gender disparity and sex-specific therapeutic strategies of hepatocellular carcinoma.
a single-nucleotide polymorphism in the amelogenin (zeige AMELX Antikörper) gene using amplified product-length polymorphisms in combination with sex-determining region Y analysis, is reported.
Missense Mutation 224G>T (R75M) in SRY Coding Region is associated with 46, XY Gonadal Dysgenesis.
Chemical proteasome inhibition restored native-like SRY expression and transcriptional activity in association with restored occupancy of a sex-specific enhancer element in principal downstream gene Sox9 (zeige SOX9 Antikörper), demonstrating that the variant SRY exhibits essentially native activity on a per molecule basis.
SRY is involved in the maintenance of cancer stem-like characteristics through OCT4 (zeige POU5F1 Antikörper).
The aim of this study was to compare two Y chromosome markers-SRY and DYS14-for their utility in the diagnosis of fetal gender
These findings demonstrate that autosomal retention of SRY can be sub-microscopic and emphasize the importance of PCR and FISH in the genetic workup of the monosomic X male
The SRY gene in plasma extracellular vesicles transferred to vascular endothelial cells may play an important role in the pathogenesis of atherosclerosis
Results show that SRY could be expressed in tissues of Hirschsprung patients. It binds to the promoter of RET (zeige RET Antikörper) gene by competing with SOX10 (zeige SOX10 Antikörper) for its interaction with PAX3 (zeige PAX3 Antikörper) and NKX2-1 (zeige NKX2-1 Antikörper) repressing their transcriptional expression and RET's as well.
High levels of SRY expression correlated with cancer progression and poor HCC (zeige FAM126A Antikörper) patient survival. However, high SRY levels are not significantly correlated with HCC (zeige FAM126A Antikörper) sex bias.
analysis of mtDNA control region sequences and SRY gene sequences indicated more contribution to the Yunnan cattle from B. indicus than from B. taurus
New insights into SRY regulation through identification of 5' conserved sequence are reported.
The 4.6 Kb of pig SRY 5' flanking sequences supported reporter transgene expression within the male genital ridge but not within the neural crest.
This case represents the first report of an SRY negative XX-male sex reversal intersex phenotype, which is a potentially inherited condition, in an American saddlebred horse.
our study demonstrates that Sp1 (zeige SP1 Antikörper) is a major regulator in SRY gene transcription, and mutations of the Sp1 (zeige SP1 Antikörper) binding sites (Sp1 (zeige SP1 Antikörper)-B and Sp1 (zeige SP1 Antikörper)-C) in the 5' flanking region of SRY induce sex reversal in rabbits
MAP2K6 (zeige MAP2K6 Antikörper) functions in mouse testis determination, via positive effects on Sry, and a minor role for MAP2K3 (zeige MAP2K3 Antikörper).
our findings support that males lacking the testis determinant Sry can be fertile and reinforce the notion that Sry does not play a role in mature gonads.
Variations in Usp9y (zeige USP9Y Antikörper) and the number of CAG repeats in Sry are significantly associated with testes weight.
Sry can be replaced by transgenic activation of its downstream target Sox9 (zeige SOX9 Antikörper). This finding supports the existence of functional redundancy between the Y chromosome genes and their homologs encoded on other chromosomes.
SRY binds to various ovarian differentiation genes and represses their activation through WNT (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling.
Studies indicate that in most of mammals, a single genetic trigger, the Y-linked gene Sry (sex determination region on Y chromosome), regulates testicular differentiation.
disprove the hypothesis that the conserved HMG (zeige SSRP1 Antikörper) box domain is the only functional domain of Sry, and highlight an evolutionary paradox whereby mouse Sry has evolved a novel bifunctional module to activate Sox9 (zeige SOX9 Antikörper) directly
this study demonstrates that live mouse progeny can also be generated by using germ cells from males with the Y chromosome contribution limited to only two genes, the testis determinant factor Sry and the spermatogonial proliferation factor Eif2s3y.
This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome)\; translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome.
essential protein for sex determination in human males
, sex-determining region Y protein
, sex-determining region on Y
, testis-determining factor on Y
, HMG box transcription factor Sry1
, HMG box transcription factor Sry3BI
, Testis determining locus
, sex determining region of Chr Y
, sex determining region on Y
, testis-determining factor
, sex determining factor Y
, sex-determining region of the Y-chromosome
, sex determining region Y protein
, sex-determining protein
, sex determining region Y
, testis determining-Y
, Sex-determining region Y protein
, Testis-determining factor
, sex determining region Y variant A
, sex determining region Y variant B
, testis determining factor
, sex determining factor SRY
, testis determining factor SRY