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SEPT4 is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Zusätzlich bieten wir Ihnen Septin 4 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal SEPT4 Primary Antibody für FACS, IHC (p) - ABIN1944842
Garcia, Rodrigues, de Oliveira Neto, de Araújo, Polikarpov, Tanaka, Tanaka, Garratt: The stability and aggregation properties of the GTPase domain from human SEPT4. in Biochimica et biophysica acta 2008
Human Polyclonal SEPT4 Primary Antibody für ELISA, WB - ABIN4352731
Lhuillier, Rode, Escalier, Lorès, Dirami, Bienvenu, Gacon, Dulioust, Touré: Absence of annulus in human asthenozoospermia: case report. in Human reproduction (Oxford, England) 2009
Septin4 is a novel essential factor involved in oxidative stress induced (zeige SQSTM1 Antikörper) vascular endothelial cell injury by interacting with apoptosis-related protein PARP1 (zeige PARP1 Antikörper).
The data suggest that Sept4_i1 induces hepatic stellate cell apoptosis by inhibiting Akt (zeige AKT1 Antikörper) and Bcl-2 (zeige BCL2 Antikörper) expression and up-regulating PPAR-gamma (zeige PPARG Antikörper) expression.
Bradeion/SEPT4 transcript levels are significantly increased in patients with transitional cell bladder cancer.We hypothesize that Bradeion is directly involved in bladder cancer pathogenesis with the highest expression at early cancer stages.
Identification of a novel anti-apoptotic E3 ubiquitin ligase (zeige MUL1 Antikörper) that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC (zeige DIABLO Antikörper), HtrA2 (zeige HTRA2 Antikörper), and ARTS.
these data suggests a tumor suppressor role of SEPT4_i1 in HCC (zeige FAM126A Antikörper) through regulating hepatocellular carcinoma cell apoptosis.
SEPT4 is a Notch (zeige NOTCH1 Antikörper) target gene.
The expression of SEPT4 is significantly decreased in the ejaculated sperm of idiopathic asthenozoospermia patients.
role of Bradeion in colorectal neoplasms
Sept4 is involved in the formation of cytoplasmic inclusions as well as induction of cell death in alpha-synuclein-associated neurodegenerative disorders.
Data suggest that ARTS induces apoptosis by antagonizing IAPs, including XIAP (zeige XIAP Antikörper).
Adenovirus-Sept4 can attenuate the development of liver fibrosis induced by S. japonicum through apoptosis.
The inhibition of the expression of the SEPT4 by praziquantel might be due to alleviation of the inflammatory response at the chronic and advanced stage of S. japonicum infection.
The hypothetical pathogenicity by the chronic overload of SEPT4 alone, if any, is insufficient to trigger neurodegenerative process in the mouse brain.
Sept4/ARTS(-/-) mice display marked improvement in wound healing and regeneration of hair follicles.
Report SEPT4/5/7 expression in mouse cochlea and roles in auditory function.
Sept4 and alpha-SMA (zeige SMN1 Antikörper) may interact together in hepatic stellate cells (HSCs). Sept4 seems to be involved in the formation of inflammatory granulomata and subsequent liver fibrosis by regulating HSCs activation.
ARTS (Septin 4) promotes apoptosis mainly through binding and antagonizing XIAP (zeige XIAP Antikörper).
Loss of Sept4 is associated with myofibroblastic transformation of hepatic stellate cells and results in liver fibrosis.
Findings suggest that Sept4-null mice develop malignancies due to increased resistance of their HSPCs to apoptosis.
This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct\; it is localized to the mitochondria, and has a role in apoptosis and cancer.
expression gene 3 in rat visual cortex
, expression gene 3-1 in rat visual cortex
, peanut-like 2
, septin 4
, CE5B3 beta
, apoptosis-related protein in the TGF-beta signaling pathway
, bradeion beta
, brain protein H5
, cell division control-related protein 2
, cerebral protein 7
, peanut-like protein 2
, cell division control-related protein 2b
, peanut-like 2 homolog
, septin H5