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SALL3 encodes a sal-like C2H2-type zinc-finger protein, and belongs to a family of evolutionarily conserved genes found in species as diverse as Drosophila, C. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.
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Cow (Bovine) Polyclonal SALL3 Primary Antibody für WB - ABIN2779729
Sweetman, Münsterberg: The vertebrate spalt genes in development and disease. in Developmental biology 2006
Human Polyclonal SALL3 Primary Antibody für ICC, IF - ABIN4351916
de Melo, Peng, Chen, Blackshaw: The Spalt family transcription factor Sall3 regulates the development of cone photoreceptors and retinal horizontal interneurons. in Development (Cambridge, England) 2011
sall3 shows aberrant methylation and downregulation in human hepatocellular carcinoma
Studies indicate that vertebrate sal orthologues (spalt (zeige SALL1 Antikörper)-like/sall) have important developmental roles during neural development and organogenesis and gentic diseases.
This functional characterization of SALL3 sheds light on regulatory mechanisms for DNMT3A (zeige DNMT3A Antikörper) and provides new strategies to inhibit aberrant methylation in cancer.
Sall3 & TH co-localize in olfactory bulb glomerular layer. Sall3 induces proximal TH promoter transcription. Sall3 deficiency causes reduction of TH expression.
Sall3 plays essential roles in horizontal cell maturation through regulation of neurofilament expression levels
Our findings demonstrate that Sall3 plays a crucial role in regulating the development of both cone photoreceptors and horizontal interneurons. Lhx1 (zeige LHX1 Antikörper) is one of the most strongly downregulated genes in Sall3 knockout mouse retinas.
The Sall3 locus has aberrant DNA methylation (zeige HELLS Antikörper) associated with abnormal placental development of cloned mice.
Data suggest that Sall3 is required for the development of nerves that are derived from the hindbrain and for the formation of adjacent branchial arch derivatives.
Sall3 is required for the terminal maturation of neurons destined for the glomerular layer.
the antagonistic interaction between Hoxa13 (zeige HOXA13 Antikörper)-Hoxd13 (zeige HOXD13 Antikörper) and Sall1 (zeige SALL1 Antikörper)-Sall3 in the developing limb may contribute to the fine-tuning of local Hox (zeige MSH2 Antikörper) activity that leads to proper morphogenesis of each cartilage element of the vertebrate autopod.
This gene encodes a sal-like C2H2-type zinc-finger protein, and belongs to a family of evolutionarily conserved genes found in species as diverse as Drosophila, C. elegans, and vertebrates. Mutations in some of these genes are associated with congenital disorders in human, suggesting their importance in embryonic development. This protein binds to DNA methyltransferase 3 alpha (DNMT3A), and reduces DNMT3A-mediated CpG island methylation. It is suggested that silencing of this gene, resulting in acceleration of DNA methylation, may have a role in oncogenesis.
C2H2 zinc finger protein SALL3
, sal-like protein 3
, spalt-like zinc finger protein
, zinc finger protein 796
, spalt-like protein 3
, sal-like 3
, zinc finger protein (Xsal-1), homolog of the region specific homeotic gene spalt
, spalt 2 protein
, sal-like 3a