SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1) ELISA Kits

The protein encoded by SMARCB1 is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. Zusätzlich bieten wir Ihnen SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 Antikörper (132) und SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 Proteine (9) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
SMARCB1 6598 Q12824
SMARCB1 20587 Q9Z0H3
Anti-Ratte SMARCB1 SMARCB1 361825  
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Top SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 ELISA Kits auf antikoerper-online.de

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Human
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$875.60
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Weitere ELISA Kits für SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 Interaktionspartner

Human SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1) Interaktionspartner

  1. Loss of SMARCB1/INI1 expression is considered to be a hallmark for childhood chordomas.

  2. Of the 34 undifferentiated endometrial carcinomas examined, 17 (50%) exhibited SWI (zeige SMARCA1 ELISA Kits)/SNF (zeige SNRPA ELISA Kits) complex inactivation, with 11 tumors showing complete loss of both ARID1A (zeige ARID1A ELISA Kits) and ARID1B (zeige ARID1B ELISA Kits), 5 showing complete loss of BRG1 (zeige SMARCA4 ELISA Kits) and 1 showing complete loss of INI1. Ten of the remaining 17 undifferentiated carcinomas showed the following alterations: 5 tumors (15%) showed loss of ARID1A (zeige ARID1A ELISA Kits) only with intact ARID1B (zeige ARID1B ELISA Kits), BRG1 (zeige SMARCA4 ELISA Kits), and INI1 expression.

  3. Our study, the first comprehensive analysis of RMC, supports a pivotal role for SMARCB1 in its development.

  4. HRAS (zeige HRAS ELISA Kits) mutations were more common in epithelial-myoepithelial carcinomas (EMCAs) with intact PLAG1 (zeige PLAG1 ELISA Kits) and HMGA2. Most EMCAs arose ex pleomorphic adenoma (PA)and the genetic profile of EMCA varies with the absence or presence of preexisting PA and its cytogenetic signature. Progression to higher grade EMCA with intact PLAG1 (zeige PLAG1 ELISA Kits) and HMGA2 correlates with the presence of TP53 (zeige TP53 ELISA Kits), FBXW7 (zeige FBXW7 ELISA Kits) mutations, or SMARCB1 deletion.

  5. Intronic hotspot variant of SMARCB1 was identified in atypical teratoid and rhabdoid tumors of two patients. This cryptic variant was absent in the germline DNA of both patients.

  6. These highly mobile and invasive cells no longer depend on KRAS signaling and rely on the aberrant activation of mesenchymal programs regulated by the chromatin remodeling factor (zeige ASH1L ELISA Kits) SMARCB1. Mouse models showed that Smarcb1 ablation could intensify cancer spread; conversely, restoring Smarcb1 slowed tumor growth and restored the cells to their less invasive, epithelial form

  7. BAF57, BAF60a (zeige SMARCD1 ELISA Kits) and SNF5 might act as novel pro-senescence factors in both normal and tumor human skin cells

  8. Low SNF5 expression is associated with Hepatocellular Carcinoma.

  9. SMARCB1 is required for widespread BAF (zeige BANF1 ELISA Kits) complex-mediated activation of enhancers and bivalent promoters.

  10. Interactions have been indicated between SMARCB1/INI1 protein and key proteins in various pathways related to tumor proliferation and progression.

Mouse (Murine) SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1) Interaktionspartner

  1. Data show that early Smarcb1 loss causes rhabdoid tumors whereas loss at later stages combined with Nf2 (zeige NF2 ELISA Kits) gene inactivation causes shwannomas.

  2. The occurrence of intracranial rhabdoid tumours depends on control of Smarcb1 inactivation.

  3. These results support recent findings regarding the effectivity of EGFR (zeige EGFR ELISA Kits) inhibitors in hindering the proliferation of human MRT cells and demonstrate that activation of EGFR (zeige EGFR ELISA Kits) signaling in Rhabdoid tumors is SMARCB1 dependent.

  4. these findings uncover a novel role for Snf5 in oligodendrocyte generation and survival, and they offer evidence of the first genetically engineered mouse model for AT/RT in the CNS.

  5. This study show here that loss of Smarcb1 and Smarca4 (zeige SMARCA4 ELISA Kits) leads to severe proliferation deficits of granule neuron precursors and a hypoplastic cerebellum.

  6. results show that Smarcb1 is required for transcriptional activation of Igfbp7 (zeige IGFBP7 ELISA Kits) and show that re-introduction of Igfbp7 (zeige IGFBP7 ELISA Kits) alone can hinder tumor development; results define a novel mechanism for Smarcb1-mediated tumorigenesis

  7. We find that inactivation of either Brg1 (zeige SMARCA4 ELISA Kits) or Smarcb1 leads to disruptions of specific nucleosome patterning combined with a loss of overall nucleosome occupancy at a large number of promoters, regardless of their association with CpG islands.

  8. SNF5 is a key mediator of Hedgehog (zeige SHH ELISA Kits) signaling and that aberrant activation of GLI1 (zeige GLI1 ELISA Kits) is a previously undescribed targetable mechanism contributing to the growth of malignant rhabdoid tumor cells.

  9. Loss of the SNF5 tumor suppressor leads to elevated expression of the Polycomb (zeige CBX2 ELISA Kits) gene EZH2 (zeige EZH2 ELISA Kits).

  10. SNF5 knockdown inhibits p53 (zeige TP53 ELISA Kits) translation by eIF4E (zeige EIF4E ELISA Kits) and replacement of eIF4E (zeige EIF4E ELISA Kits) in SNF5 knockdown cells restores p53 (zeige TP53 ELISA Kits) expression and cell survival

SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1) Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Two transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit SMARCB1

  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (SMARCB1) Antikörper
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (Smarcb1) Antikörper
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 S homeolog (smarcb1.S) Antikörper
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1b (smarcb1b) Antikörper
  • AU020204 Antikörper
  • Baf47 Antikörper
  • fc51b01 Antikörper
  • hSNFS Antikörper
  • Ini1 Antikörper
  • MRD15 Antikörper
  • RDT Antikörper
  • RTPS1 Antikörper
  • Sfh1p Antikörper
  • smarcb1 Antikörper
  • Snf5 Antikörper
  • SNF5/INI1 Antikörper
  • SNF5L1 Antikörper
  • Snr1 Antikörper
  • wu:fc51b01 Antikörper

Bezeichner auf Proteinebene für SMARCB1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 , matrix metalloproteinase 11 (stromelysin 3) , BAF47 , BRG1-associated factor 47 , SNF5 homolog , hSNF5 , integrase interactor 1 protein , malignant rhabdoid tumor suppressor , sucrose nonfermenting, yeast, homolog-like 1 , mSNF5 , SWI/SNF-related matrix associated protein

GENE ID SPEZIES
769489 Gallus gallus
537412 Bos taurus
6598 Homo sapiens
20587 Mus musculus
443934 Xenopus laevis
486407 Canis lupus familiaris
361825 Rattus norvegicus
30731 Danio rerio
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