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Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. Zusätzlich bieten wir Ihnen SUMO1 Activating Enzyme Subunit 2 Proteine (6) und SUMO1 Activating Enzyme Subunit 2 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal UBA2 Primary Antibody für WB - ABIN4351883
Pal, Santos, Rosas, Ortiz-Guzman, Rosas-Acosta: Influenza A virus interacts extensively with the cellular SUMOylation system during infection. in Virus research 2011
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Human Polyclonal UBA2 Primary Antibody für WB - ABIN2801891
Okuma, Honda, Ichikawa, Tsumagari, Yasuda: In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2. in Biochemical and biophysical research communications 1999
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Human Polyclonal UBA2 Primary Antibody für ELISA - ABIN268798
Desterro, Rodriguez, Kemp, Hay: Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1. in The Journal of biological chemistry 1999
Human Polyclonal UBA2 Primary Antibody für ELISA, IF - ABIN185083
Kanemaru, Saitoh: High-yield expression of mouse Aos1-Uba2-fusion SUMO-activating enzyme, mAU, in a baculovirus-insect cell system. in Bioscience, biotechnology, and biochemistry 2013
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results from the present study indicated that UBA2 expression may enhance colorectal cancer cell proliferation and inhibit apoptosis.
Uba2 plays a vital role in gastric cancer cell migration and invasion, possibly by regulating the Wnt/beta-catenin signaling pathway and epithelial-mesenchymal transition.
Calcium/calpain-induced cleavage of the SAE2 leads to sumoylation inhibition reslting in bacillary dysentery.
We propose that disturbance of the SUMOylation pathway, mediated by pathogenic variants in UBA2, is a novel mechanism for aplasia cutis congenita and other phenotypic abnormalities.
Here, we show that hHR23A utilizes both the UBA2 and XPCB domains to form a stable complex with Vpr, linking Vpr directly to cellular DNA repair pathways and their probable exploitation by the virus.
This study has identified the mechanism used to localize SAE to the nucleus.
Data indicate the role of anti-SUMO activating enzyme SAE1 and SAE2 antibody as marker of dermatomyositis.
Data show that the SAE2 subunit of the small ubiquitin-like modifier (SUMO) E1 is autoSUMOylated at residue Lys-236, and SUMOylation was catalyzed by Ubc9 at several additional Lys residues surrounding the catalytic Cys-173 of SAE2.
loss of SAE1/2 activity drives synthetic lethality with Myc; inactivation of SAE2 leads to mitotic catastrophe and cell death upon Myc hyperactivation; findings in Myc-high breast cancers suggest low tumor SAE1 and SAE2 correlates metastasis-free survival
The mammalian E1 subunits can be imported separately, identify nuclear localization signals (NLSs) in Aos1 and in Uba2, and demonstrate that their import is mediated by importin alpha/beta in vitro and in intact cells.
structures of heterodimeric Sae1/Sae2-Mg.ATP and Sae1/Sae2-SUMO-1-Mg.ATP complexes
UBA2 stabilizes APOBEC3G by preventing ubiquitin chain elongation and proteasome-mediated proteolysis.
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1\; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999
SUMO1 activating enzyme subunit 2
, SUMO-1 activating enzyme subunit 2
, SUMO-activating enzyme subunit 2
, UBA2, ubiquitin-activating enzyme E1 homolog
, anthracycline-associated resistance ARX
, ubiquitin-like 1-activating enzyme E1B
, Sumo-1 activating enzyme subunit 2
, ubiquitin-like 1 (sentrin) activating enzyme E1B
, ubiquitin-like 1 (sentrin) activating enzyme subunit 2
, SUMO-activating enzyme subunit 2-A
, SUMO-activating enzyme subunit 2-B
, ubiquitin-like 1-activating enzyme E1B-A
, ubiquitin-like 1-activating enzyme E1B-B
, SUMO1 activating enzyme subunit 2b