anti-SUB1 Homolog (S. Cerevisiae) (SUB1) Antikörper

expressed in 12 day embryo and in a chemically induced pancreatic B-cell tumor; not expressed in normal differentiated cells. Zusätzlich bieten wir Ihnen SUB1 Kits (24) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SUB1 10923 P53999
SUB1 20024 P11031
SUB1 192269 Q63396
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Top anti-SUB1 Antikörper auf antikoerper-online.de

Showing 10 out of 70 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IHC (p), WB PC4 was detected in paraffin-embedded sections of human mammary cancer tissues using rabbit anti- PC4 Antigen Affinity purified polyclonal antibody (Catalog # ) at 1 µg/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022). PC4 was detected in paraffin-embedded sections of mouse liver tissues using rabbit anti- PC4 Antigen Affinity purified polyclonal antibody (Catalog # ) at 1 µg/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022). 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$280.00
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB WB Suggested Anti-PC4 Antibody Titration:  2.5ug/ml  Positive Control:  Raji cell lysate There is BioGPS gene expression data showing that SUB1 is expressed in Raji Human Lung 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$229.00
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB WB Suggested Anti-PC4 Antibody Titration:  0.5-1.0ug/ml  Positive Control:  HepG2 cell lysate There is BioGPS gene expression data showing that SUB1 is expressed in HepG2 Human Liver 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$249.00
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Western Blot and Immunoprecipitation: PC4 Antibody [ABIN252962] - Detection of Human PC4 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (5, 15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-PC4 antibody ABIN252962 used for WB at 0.04 mcg/ml (A) and 0.1 mcg/ml (B). PC4 was immunoprecipitated by rabbit anti-PC4 antibody ABIN252961, which recognizes an upstream epitope. Immunohistochemistry-Paraffin: SUB1 Antibody [ABIN2529625] - FFPE section of human prostate carcinoma. Affinity purified rabbit anti-PC4 used at a dilution of 1:250. Detection: DAB staining using Immunohistochemistry Accessory Kit 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$559.35
Details
Human Kaninchen Unkonjugiert IF/ICC, IHC, IP, WB Western blot analysis of extracts of various cell lines, using SUB1 antibody (ABIN5974252) at 1/1000 dilution. Immunohistochemistry of paraffin-embedded human stomach using SUB1 antibody (ABIN5974252) at dilution of 1/100 (40x lens). 100 μL Anmelden zum Anzeigen 11 bis 16 Tage
$426.40
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, IHC (p), WB 100 μg Anmelden zum Anzeigen 11 bis 14 Tage
$493.17
Details
Human Kaninchen Unkonjugiert WB SUB1 Antibody (Center) (ABIN1881856) western blot analysis in K562 cell line lysates (35 µg/lane). This demonstrates the SUB1 antibody detected the SUB1 protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$385.00
Details
Human Kaninchen Unkonjugiert IF, IHC, IP, WB Western blot analysis of extracts of various cell lines, using SUB1 antibody. Immunohistochemistry of paraffin-embedded human stomach using SUB1 antibody. 200 μL Anmelden zum Anzeigen 12 bis 14 Tage
$438.90
Details
Huhn Kaninchen Unkonjugiert IHC, IHC (p), WB 100 μg Anmelden zum Anzeigen 11 bis 14 Tage
$493.17
Details
Human Kaninchen Unkonjugiert IF, IHC (p), WB Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human breast with SUB1 polyclonal antibody  shows strong nuclear positivity in glandular cells. Western blot analysis of lane 1: RT-4, lane 2: U-251 MG, lane 3: A-431, lane 4: Liver and lane 5: Tonsil using SUB1 polyclonal antibody . 100 μL Anmelden zum Anzeigen 11 bis 12 Tage
$452.00
Details

Am meisten referenzierte anti-SUB1 Antikörper

  1. Human Polyclonal SUB1 Primary Antibody für WB - ABIN1881856 : Das, Gadad, Kundu: Human positive coactivator 4 controls heterochromatinization and silencing of neural gene expression by interacting with REST/NRSF and CoREST. in Journal of molecular biology 2010 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal SUB1 Primary Antibody für ICC, IF - ABIN4356694 : Chakravarthi, Goswami, Pathi, Robinson, Cieślik, Chandrashekar, Agarwal, Siddiqui, Daignault, Carskadon, Jing, Chinnaiyan, Kunju, Palanisamy, Varambally: MicroRNA-101 regulated transcriptional modulator SUB1 plays a role in prostate cancer. in Oncogene 2016 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal SUB1 Primary Antibody für ICC, IF - ABIN252962 : Lin, Chang, Hsu, Chi, Chien, Liang, Tsai, Lin, Yu: Low-molecular-mass secretome profiling identifies C-C motif chemokine 5 as a potential plasma biomarker and therapeutic target for nasopharyngeal carcinoma. in Journal of proteomics 2013 (PubMed)

Weitere Antikörper gegen SUB1 Interaktionspartner

Human SUB1 Homolog (S. Cerevisiae) (SUB1) Interaktionspartner

  1. Study shows that PC4 might repress RNA pol II recruitment and transcription of replication-dependent histone genes in order to maintain the balance between histone gene expression and DNA synthesis. Moreover, PC4 might promote the interaction of cleavage and polyadenylation complex with histone pre-mRNAs, that might impede with the recruitment of histone cleavage complex.

  2. REVIEW: many evidences showed that Sub1 influences processes downstream during mRNA biogenesis, such as elongation, termination, and RNAPII phosphorylation. The recent discovery that Sub1 directly interacts with the RNAPII stalk adds new insights into how it achieves all these tasks.

  3. Evolutionarily conserved role for Sub1 and PC4 in the maintenance of yeast and human genome stability has been summarized. (Review)

  4. Yeast Sub1 and human PC4 are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNA.

  5. Results show elevated expression of SUB1 in aggressive prostate cancer. Knockdown of SUB1 in prostate cancer cells resulted in reduced cell proliferation, invasion and migration.

  6. these data provide a novel mode of PC4 binding to a DNA secondary structure that remains within the framework of the model for binding to ssDNA. Additionally, consideration of the PC4-G4DNA interaction could provide insight into the biological functions of PC4, which remain incompletely understood.

  7. PC4 associates with Aurora A and Aurora B and undergoes phosphorylation, following which PC4 activates both Aurora A and B to sustain optimal kinase activity to maintain the phosphorylation gradient for the proper functioning of the mitotic machinery.

  8. PC4 has similar functions to RPA in binding ssDNA to promote genome stability, especially at sites of replication-transcription collisions.

  9. SMYD3 interacts with the human positive coactivator 4 (PC4) and that such interaction potentiates a group of genes whose expression is linked to cell proliferation and invasion.

  10. Sub1, and its human homolog PC4, bind preferentially to G-quadruplexes

  11. expression of PC4 in astrocytoma was upregulated as assessed by western blot and immunohistochemical staining. Moreover, elevated PC4 expression was strongly correlated with the progression of astrocytoma and overall survival.

  12. PC4 protects esophageal squamous cell carcinoma cells from IR-induced death by enhancing the nonhomologous end joining-promoting activity of XLF.

  13. p38 MAP kinase mediated HNF4 Ser158 phosphorylation (P-HNF4-S158), binding of PC4 to P-HNF4-S158 and characterize the functional domain of PC4 required for P-HNF4-S158 binding.

  14. PC4 activates double-strand break (DSB) repair activity through stimulation of DSB rejoining in vivo

  15. acetylation of lysine 382/381 of p53 may play an important role in modulating p53-PC4 interaction and as a consequence PC4 mediated activation of p53 target genes.

  16. findings demonstrated a critical aspect of LHR modulation whereby PC4 acts as a coactivator of Sp1 to contribute to the human of LHR transcription

  17. Sub1/PC4 a chromatin associated protein with multiple functions in transcription.

  18. analysis of the interaction between the transactivation domain of p53 and PC4

  19. PC4 interacts with the DNA binding and C-terminal domains of p53 through its DNA binding domain, which is essential for the stimulation of p53 DNA binding.

  20. PC4 interacts with heterochromatin protein 1alpha, REST/NRSF (RE1-silencing transcription factor/neuron-restrictive silencer factor) and CoREST to establish the repressed state of neural genes in nonneuronal cells.

Mouse (Murine) SUB1 Homolog (S. Cerevisiae) (SUB1) Interaktionspartner

  1. These observations indicate that non-histone chromatin-associated proteins like PC4 play a significant role in neuronal plasticity.

  2. Results suggest that positive cofactor 4 (Pc4) has an important role in inducing spontaneous somatic cell reprogramming via up-regulation of key pluripotency genes.

  3. Redox-mediated upregulation of hepatocyte iNOS transcription requires an HNF-4alpha-PC4 transcriptional complex

  4. Report recruitment of RNA polymerase II cofactor PC4 to DNA damage sites.

SUB1 Antigen-Profil

Protein Überblick

expressed in 12 day embryo and in a chemically induced pancreatic B-cell tumor; not expressed in normal differentiated cells

Genbezeichner und Symbole assoziert mit SUB1

  • SUB1 homolog, transcriptional regulator (SUB1) Antikörper
  • SUB1 homolog (S. cerevisiae) (Sub1) Antikörper
  • SUB1 homolog, transcriptional regulator (Sub1) Antikörper
  • AI842364 Antikörper
  • P9 Antikörper
  • p14 Antikörper
  • P15 Antikörper
  • Pc4 Antikörper
  • Rpo2tc1 Antikörper

Bezeichner auf Proteinebene für SUB1

activated RNA polymerase II transcription cofactor 4 , activated RNA polymerase II transcriptional coactivator p15 , positive cofactor 4 , RNA polymerase II transcriptional coactivator , p14 , single-stranded DNA-binding protein p9 , PC4 , pR-ET2 encoded oncodevelopmental protein

GENE ID SPEZIES
10923 Homo sapiens
20024 Mus musculus
192269 Rattus norvegicus
427425 Gallus gallus
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