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expressed in 12 day embryo and in a chemically induced pancreatic B-cell tumor; not expressed in normal differentiated cells. Zusätzlich bieten wir Ihnen SUB1 Kits (24) und und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 70 products:
Human Polyclonal SUB1 Primary Antibody für WB - ABIN1881856
Das, Gadad, Kundu: Human positive coactivator 4 controls heterochromatinization and silencing of neural gene expression by interacting with REST/NRSF and CoREST. in Journal of molecular biology 2010
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Human Polyclonal SUB1 Primary Antibody für ICC, IF - ABIN4356694
Chakravarthi, Goswami, Pathi, Robinson, Cieślik, Chandrashekar, Agarwal, Siddiqui, Daignault, Carskadon, Jing, Chinnaiyan, Kunju, Palanisamy, Varambally: MicroRNA-101 regulated transcriptional modulator SUB1 plays a role in prostate cancer. in Oncogene 2016
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Human Polyclonal SUB1 Primary Antibody für ICC, IF - ABIN252962
Lin, Chang, Hsu, Chi, Chien, Liang, Tsai, Lin, Yu: Low-molecular-mass secretome profiling identifies C-C motif chemokine 5 as a potential plasma biomarker and therapeutic target for nasopharyngeal carcinoma. in Journal of proteomics 2013
Evolutionarily conserved role for Sub1 and PC4 (zeige IFRD1 Antikörper) in the maintenance of yeast and human genome stability has been summarized. (Review)
Yeast Sub1 and human PC4 (zeige IFRD1 Antikörper) are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNA.
Results show elevated expression of SUB1 in aggressive prostate cancer. Knockdown of SUB1 in prostate cancer cells resulted in reduced cell proliferation, invasion and migration.
these data provide a novel mode of PC4 (zeige IFRD1 Antikörper) binding to a DNA secondary structure that remains within the framework of the model for binding to ssDNA. Additionally, consideration of the PC4 (zeige IFRD1 Antikörper)-G4DNA interaction could provide insight into the biological functions of PC4 (zeige IFRD1 Antikörper), which remain incompletely understood.
PC4 (zeige IFRD1 Antikörper) associates with Aurora A (zeige AURKA Antikörper) and Aurora B (zeige AURKB Antikörper) and undergoes phosphorylation, following which PC4 (zeige IFRD1 Antikörper) activates both Aurora A (zeige AURKA Antikörper) and B to sustain optimal kinase activity to maintain the phosphorylation gradient for the proper functioning of the mitotic machinery.
PC4 has similar functions to RPA in binding ssDNA to promote genome stability, especially at sites of replication-transcription collisions.
SMYD3 (zeige SMYD3 Antikörper) interacts with the human positive coactivator 4 (PC4 (zeige IFRD1 Antikörper)) and that such interaction potentiates a group of genes whose expression is linked to cell proliferation and invasion.
Sub1, and its human homolog PC4 (zeige IFRD1 Antikörper), bind preferentially to G-quadruplexes
expression of PC4 (zeige IFRD1 Antikörper) in astrocytoma was upregulated as assessed by western blot and immunohistochemical staining. Moreover, elevated PC4 (zeige IFRD1 Antikörper) expression was strongly correlated with the progression of astrocytoma and overall survival.
PC4 (zeige IFRD1 Antikörper) protects esophageal squamous cell carcinoma cells from IR-induced death by enhancing the nonhomologous end joining-promoting activity of XLF (zeige NHEJ1 Antikörper).
These observations indicate that non-histone chromatin-associated proteins like PC4 (zeige IFRD1 Antikörper) play a significant role in neuronal plasticity.
Results suggest that positive cofactor 4 (Pc4) has an important role in inducing spontaneous somatic cell reprogramming via up-regulation of key pluripotency genes.
Redox-mediated upregulation of hepatocyte iNOS (zeige NOS2 Antikörper) transcription requires an HNF-4alpha (zeige HNF4A Antikörper)-PC4 (zeige IFRD1 Antikörper) transcriptional complex
Report recruitment of RNA polymerase II (zeige 0 Antikörper) cofactor PC4 (zeige IFRD1 Antikörper) to DNA damage sites.
expressed in 12 day embryo and in a chemically induced pancreatic B-cell tumor; not expressed in normal differentiated cells
activated RNA polymerase II transcription cofactor 4
, activated RNA polymerase II transcriptional coactivator p15
, positive cofactor 4
, RNA polymerase II transcriptional coactivator
, single-stranded DNA-binding protein p9
, pR-ET2 encoded oncodevelopmental protein