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putative serine/threonine protein kinase [RGD, Feb 2006]..
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SLK (zeige FYN Antikörper) interacts with Tpr and alpha-actinin-4 (zeige ACTN4 Antikörper) in cells, and these protein-protein interactions may control the subcellular localization and the biological activity of SLK (zeige FYN Antikörper).
SLK (zeige FYN Antikörper) activated ERMs, together with Galphai, are critical for the correct localization of LGN (zeige GPSM2 Antikörper)-NuMA (zeige NUMA1 Antikörper) force generator complexes and hence for proper spindle orientation.
The fact that SLK (LOSK) phosphorylates only a minor isoform 1A of p150(Glued (zeige DCTN1 Antikörper)) suggests that transport and microtubule-organizing functions of dynactin (zeige DCTN1 Antikörper) are distinctly divided between the two isoforms
It was shown that lymphocyte-oriented and STE20 kinase were sufficient to restrict ezrin (zeige EZR Antikörper) function to the apical domain. Both kinases were enriched in microvilli and locally activated there.
v-Src (zeige SRC Antikörper)-dependent down-regulation of the Ste20-like kinase SLK through casein kinase II (zeige CSNK2A1 Antikörper).
we show that a novel isoform of SPS1 (zeige SRM Antikörper)-related proline alanine-rich kinase (SPAK (zeige STK39 Antikörper)/STE20 (zeige STK24 Antikörper)) is involved in this inflammatory signaling cascade
Protein kinase (zeige CDK7 Antikörper) LOSK is required for radial microtubule organization and for the proper localization of Golgi complex in various cell types.
Studies define an interaction between Neu (zeige ERBB2 Antikörper) and SLK (zeige FYN Antikörper) signaling in the regulation of cancer cell motility.
Loss of SLK impairs myofiber stability and function.
kinases, including Slk, Lok (zeige STK10 Antikörper) and Mst1 (zeige MST1 Antikörper), are inhibited by BI-D1870 but to a much lesser extent by BIX 02565 and that phosphorylation of some of their substrates is blocked by BI-D1870 in living cells.
activation of SLK by haptotactic signals requires its recruitment to the leading edge by LMO4 (zeige LMO4 Antikörper) in a Src (zeige SRC Antikörper)-dependent manner.
Essential role for the SLK protein kinase in embryogenesis and placental tissue development.
SLK phosphorylates the adhesion adapter protein (zeige GRB10 Antikörper) paxillin (zeige PXN Antikörper) on serine 250. This is required for FAK (zeige PTK2 Antikörper)-dependent focal adhesion dynamics.
Data suggest that podocyte Ste20-like kinase (SLK) overexpression in vivo results in injury and podocyte loss, consistent with the effects of SLK in cultured cells.
Data suggest that Ldb1 (zeige LDB1 Antikörper)/2 function to maintain SLK in an inactive state before its activation.
Associates with microtubules and has a role in Rac1-mediated regulation of actin dynamics during cell adhesion and spreading
SLK is expressed in the neurons and neuroepithelium of the developing embryo in the forebrain, midbrain and hindbrain. Following middle cerebral artery occlusion, SLK neurons are lost and SLK is localized to phagocytic macrophages/microglia.
SLK expression induced in Myf5 (zeige MYF5 Antikörper)- and Pax7 (zeige PAX7 Antikörper)-positive activated satellite cells during regeneration and expression of dominant negative Ste20-like kinase SLK in C2C12 cultures impairs myoblast fusion
putative serine/threonine protein kinase
STE20-like serine/threonine-protein kinase
, CTCL tumor antigen se20-9
, Long Ste20-like Kinase
, SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose nonfermenting like kinase
, SNF1 sucrose nonfermenting like kinase
, STE20-related kinase
, STE20-related serine/threonine-protein kinase
, Ste20-related serine/threonine kinase
, serine/threonine-protein kinase 2
, STE20-related kinase SMAK
, serine/threonine kinase 2
, serine/threoine kinase