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SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. Zusätzlich bieten wir Ihnen SHPRH Kits (4) und und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 77 products:
Human Polyclonal SHPRH Primary Antibody für IHC - ABIN967027
Sood, Makalowska, Galdzicki, Hu, Eddings, Robbins, Moses, Namkoong, Chen, Trent: Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region. in Genomics 2003
Show all 4 Pubmed References
Human Monoclonal SHPRH Primary Antibody für WB - ABIN2732011
Zeman, Lin, Freire, Cimprich: DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis. in The Journal of cell biology 2014
This study suggests that SHPRH could be a link between mTOR-mediated epigenetic regulations and rRNA transcription, while concomitantly affecting genomic integrity.
evidence that SHPRH functions in rRNA transcription through its interaction with histone H3 in a mammalian target of rapamycin (mTOR)-dependent manner
HLTF and SHPRH suppress mutagenesis in a damage-specific manner, preventing mutations induced by UV rays and methyl methanesulfonate.
SHPRH maps to 6q24 and is a possible candidate for the tumor suppressor gene reported from that region.
SHPRH function is an important deterrent to mutagenesis and carcinogenesis in humans
We report that a putative tumor suppressor gene, SHPRH, is a human orthologue of yeast RAD5.The yRad5/SHPRH-dependent pathway is a conserved and fundamental DNA repair mechanism that protects the genome from genotoxic stress.
HLTF and SHPRH are functional homologues of yeast Rad5 that cooperatively mediate PCNA polyubiquitination and maintain genomic stability.
SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006
, E3 ubiquitin-protein ligase SHPRH
, SNF2, histone-linker, PHD and RING finger domain-containing helicase
, SNF2 histone linker PHD RING helicase