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SNRK is a member of the sucrose nonfermenting (SNF)-related kinase family of serine/threonine kinases (Kertesz et al., 2002 [PubMed 12234663]).[supplied by OMIM, Apr 2009].. Zusätzlich bieten wir Ihnen SNRK Antikörper (54) und SNRK Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
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Study shows that TRIB3 binds to SNRK, and downregulates UCP3 through PPARalpha. SNRK is increased in cardiomyopathy patients, and SNRK reduces infarct size after ischaemia/reperfusion. SNRK also decreases cardiac cell death in a UCP3-dependent manner.
Report the crystal structure of an N-terminal SNRK fragment containing kinase and adjacent ubiquitin-associated (UBA) domains. This structure shows that the UBA domain binds between the N- and C-lobes of the kinase domain. The mode of UBA binding in SNRK largely resembles that in AMPK and brain specific kinase (BRSK), however, unique interactions play vital roles in stabilizing the KD-UBA interface of SNRK.
SNRK in cardiomyocytes is responsible for maintaining cardiac metabolic homeostasis, which is mediated in part by ROCK, and alteration of this homeostasis influences cardiac function in the adult heart.
Differential expression of SNRK in early versus late stage disease suggests specific roles for SNRK in ovarian cancer metastasis.
These findings reveal a novel function for SNRK in the regulation of colon cancer cell proliferation and beta-catenin signaling.
SNRK could mediate some of the physiological effects of LKB1
SNRK is a member of the sucrose nonfermenting (SNF)-related kinase family of serine/threonine kinases (Kertesz et al., 2002
SNF-1 related kinase
, SNF-related serine/threonine-protein kinase
, SNF1-related kinase