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SNRK is a member of the sucrose nonfermenting (SNF)-related kinase family of serine/threonine kinases (Kertesz et al., 2002 [PubMed 12234663]).[supplied by OMIM, Apr 2009].. Zusätzlich bieten wir Ihnen SNRK Kits (6) und SNRK Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 53 products:
Cow (Bovine) Polyclonal SNRK Primary Antibody für WB - ABIN2786629
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007
Human Polyclonal SNRK Primary Antibody für IHC (p), WB - ABIN652303
Cossette, Gastonguay, Bao, Lerch-Gaggl, Zhong, Harmann, Koceja, Miao, Vakeel, Chun, Li, Foeckler, Bordas, Weiler, Strande, Palecek, Ramchandran: Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism. in Biology open 2015
Study shows that TRIB3 binds to SNRK, and downregulates UCP3 through PPARalpha. SNRK is increased in cardiomyopathy patients, and SNRK reduces infarct size after ischaemia/reperfusion. SNRK also decreases cardiac cell death in a UCP3-dependent manner.
Report the crystal structure of an N-terminal SNRK fragment containing kinase and adjacent ubiquitin-associated (UBA) domains. This structure shows that the UBA domain binds between the N- and C-lobes of the kinase domain. The mode of UBA binding in SNRK largely resembles that in AMPK (zeige PRKAA1 Antikörper) and brain specific kinase (zeige EPHA5 Antikörper) (BRSK), however, unique interactions play vital roles in stabilizing the KD-UBA interface of SNRK.
SNRK in cardiomyocytes is responsible for maintaining cardiac metabolic homeostasis, which is mediated in part by ROCK, and alteration of this homeostasis influences cardiac function in the adult heart.
Differential expression of SNRK in early versus late stage disease suggests specific roles for SNRK in ovarian cancer metastasis.
These findings reveal a novel function for SNRK in the regulation of colon cancer cell proliferation and beta-catenin (zeige CTNNB1 Antikörper) signaling.
SNRK could mediate some of the physiological effects of LKB1 (zeige STK11 Antikörper)
Using SNRK transgenic and KO mouse models, study found that SNRK decreases cardiac metabolic substrate usage and mitochondrial coupling, while protecting against ischaemia/reperfusion injury. Effects on substrate usage and cell death are dependent on UCP3 (zeige UCP3 Antikörper), which is downregulated through suppression of PPARalpha (zeige PPARA Antikörper) by Trib3 (zeige TRIB3 Antikörper), a novel binding partner of SNRK.
SNRK may act as a suppressor of adipocyte inflammation and its presence is necessary for maintaining normal adipocyte function.
SNRK is a member of the sucrose nonfermenting (SNF)-related kinase family of serine/threonine kinases (Kertesz et al., 2002
SNF-1 related kinase
, SNF-related serine/threonine-protein kinase
, SNF1-related kinase